208 |
AKT SERINE/THREONINE KINASE 2 |
AKT2 |
HIHGHH |
PKBB |
PKBBETA |
PRKBB |
RAC-BETA |
164731 |
392 |
ENSG00000105221 |
OTTHUMG00000137375 |
AKT2_HUMAN |
P31751 |
RAC-BETA SERINE/THREONINE-PROTEIN KINASE |
254 |
RAC-PK-beta |
Protein kinase Akt-2 |
PKB beta |
Protein kinase B beta |
RAC-BETA SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAC-PK-BETA) (PROTEIN KINASE AKT-2) (PROTEIN KINASE B, BETA) (PKB BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P31751] |
Interpro Name | Serine/threonine- / dual-specificity protein kinase, catalytic domain |
Interpro Type | Domain |
Uniprot Evidence | 1: Evidence at protein level |
Uniprot Status | Swiss-Prot |
Human Readable Name | DRUGGABLE GENOME |
Human Readable Name | KINASE |
Interpro Acc | IPR002290 |
Interpro Short Name | Ser/Thr_dual-sp_kinase_dom |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.1 |
Gene Biotype | PROTEIN_CODING |
TRANSPORTER |
TUMOR SUPPRESSOR |
KINASE |
SERINE THREONINE KINASE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
ENZYME |
TRANSCRIPTION FACTOR |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase AKT inhibitor |
Direct Interaction | yes |
Trial Name | GDC-0068 |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase AKT2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | XL418 |
Novel drug target | Novel Target |
Mechanism of Interaction | Serine/threonine-protein kinase AKT inhibitor |
n/a |
Trial Name | triciribine-phosphate, TCN-P, VQD-002 |
Novel drug target | Novel Target |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase AKT inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase AKT inhibitor |
Direct Interaction | yes |
n/a |
Trial Name | RX-0201,Archexin |
Novel drug target | Novel Target |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase AKT inhibitor |
allosteric modulator |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase AKT inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase AKT inhibitor |
Direct Interaction | yes |
allosteric modulator |
inhibitor (inhibitory) |
Trial Name | MK-2206 |
Novel drug target | Novel Target |
Mechanism of Interaction | Serine/threonine-protein kinase AKT inhibitor |
n/a |
Trial Name | perifosine, KRX-0401 |
Novel drug target | Novel Target |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serine/threonine-protein kinase AKT inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase AKT inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Serine/threonine-protein kinase AKT inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
AKT2 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
AKT2 | Display Id |
RAC-BETA SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAC-PK-BETA) (PROTEIN KINASE AKT-2) (PROTEIN KINASE B, BETA) (PKB BETA). [SOURCE:UNIPROT/SWISSPROT;ACC:P31751] | Description |
ENSG00000105221 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
AKT2 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.1 |
208 | Entrez Gene Id |
P31751 | Uniprot Accession |
ENSG00000105221 | Ensembl Gene Id |
Interpro Name | Serine/threonine- / dual-specificity protein kinase, catalytic domain |
Interpro Type | Domain |
Uniprot Evidence | 1: Evidence at protein level |
KINASE, DRUGGABLE GENOME |
208 | Entrez Gene ID |
254 | CIViC Gene ID |
ENSG00000105221 | Gene Symbol |
AKT2 | Ensembl Id |
DRUGGABLE GENOME |
AKT2 | GENE_SYMBOL |
RAC-beta serine/threonine-protein kinase | UNIPROT |
Protein kinase Akt-2 | UNIPROT |
ENSG00000105221 | Ensembl Gene ID |
AKT serine/threonine kinase 2 | Human Protein Atlas Gene Description |
P31751 | UniProt ID |
ENZYME |
AKT2 | Gene Symbol |
CLINICALLY ACTIONABLE |
208 | Gene ID |
HIHGHH | dGene Synonym |
PKBB | dGene Synonym |
KINASE, SERINE THREONINE KINASE |
RAC-beta serine/threonine-protein kinase | Gene Name |
P31751 | UniProt ID |
TRANSPORTER, KINASE, TRANSCRIPTION FACTOR |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
TUMOR SUPPRESSOR, SERINE THREONINE KINASE |
CLINICALLY ACTIONABLE |