DGIdb - AKT3 Gene Record

AKT3 10000 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

10000
AKT SERINE/THREONINE KINASE 3
AKT3
MPPH
MPPH2
PKB-GAMMA
PKBG
PRKBG
RAC-PK-gamma
RAC-gamma
STK-2
611223
393
ENSG00000117020
OTTHUMG00000039994
AKT3_HUMAN
Q9Y243
RAC-gamma serine/threonine-protein kinase
PKB gamma
Protein kinase B gamma
Protein kinase Akt-3
7936
RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAC-PK-GAMMA) (PROTEIN KINASE AKT-3) (PROTEIN KINASE B, GAMMA) (PKB GAMMA) (STK-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y243]
T71266

Gene Info:

Target Class	Enzymes
Target Subclass	EC:2.7.11.1
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Human Readable Name	KINASE
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Acc	IPR002290
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Gene Biotype	PROTEIN_CODING

(16 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUG RESISTANCE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Shi H et al., 2014, Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy., Cancer Discov
Liu P et al., 2009, Targeting the phosphoinositide 3-kinase pathway in cancer., Nat Rev Drug Discov

XL-418 AKT3

Interaction Score: 2.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Trial Name XL418

PMIDs:
19644473

Sources:
TdgClinicalTrial ChemblInteractions TTD
IPATASERTIB AKT3

Interaction Score: 1.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name GDC-0068

Novel drug target Novel Target

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions MyCancerGenomeClinicalTrial
AFURESERTIB AKT3

Interaction Score: 1.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
TRICIRIBINE AKT3

Interaction Score: 1.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name triciribine-phosphate, TCN-P, VQD-002

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial
MK-2201 AKT3

Interaction Score: 0.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MIRANSERTIB AKT3

Interaction Score: 0.94

Interaction Types & Directionality:

allosteric modulator

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
AZD-5363 AKT3

Interaction Score: 0.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SR-13668 AKT3

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ARCHEXIN AKT3

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name RX-0201,Archexin

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
MSC-2363318A AKT3

Interaction Score: 0.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase AKT3 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD
TRICIRIBINE PHOSPHATE AKT3

Interaction Score: 0.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
UPROSERTIB AKT3

Interaction Score: 0.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
MK-2206 AKT3

Interaction Score: 0.83

Interaction Types & Directionality:

allosteric modulator

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Direct Interaction yes

Trial Name MK-2206

PMIDs:
None found

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions MyCancerGenomeClinicalTrial TTD
CAPIVASERTIB AKT3

Interaction Score: 0.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial TTD
LY-2780301 AKT3

Interaction Score: 0.56

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PERIFOSINE AKT3

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name perifosine, KRX-0401

PMIDs:
None found

Sources:
TdgClinicalTrial
GSK-690693 AKT3

Interaction Score: 0.33

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD
VEMURAFENIB AKT3

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24265155

Sources:
CIViC
OMIPALISIB AKT3

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenomeClinicalTrial
FASUDIL AKT3

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EVEROLIMUS AKT3

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenomeClinicalTrial
GSK-269962A AKT3

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000117020
- Version: 101_38
Alternate Names:

AKT3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q9Y243
- Version: 11-September-2012
Alternate Names:

ENSG00000117020 Ensembl Gene Id

AKT3_HUMAN Uniprot Id

AKT3 Uniprot Gene Name

Gene Info:

Interpro Type Domain

Uniprot Evidence 1: Evidence at protein level

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000117020

Version: 26-July-2011

Alternate Names:

RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAC-PK-GAMMA) (PROTEIN KINASE AKT-3) (PROTEIN KINASE B, GAMMA) (PKB GAMMA) (STK-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y243] Description

AKT3 Display Id

ENSG00000117020 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q9Y243
- Version: January-2014
Alternate Names:

AKT3 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.1

Publications:

CIViC: AKT3

Version: 14-September-2020

Alternate Names:

10000 Entrez Gene ID

7936 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Shi H et al., 2014, Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy., Cancer Discov

Stottrup et al., 2016, Upregulation of AKT3 Confers Resistance to the AKT Inhibitor MK2206 in Breast Cancer., Mol. Cancer Ther.

Chin et al., 2014, Targeting Akt3 signaling in triple-negative breast cancer., Cancer Res.

TTD: RAC-gamma serine/threonine-protein kinase
- Version: 2020.06.01
Alternate Names:

AKT3 TTD Gene Abbreviation

T71266 TTD Target ID

Gene Info:

Publications:

Liu P et al., 2009, Targeting the phosphoinositide 3-kinase pathway in cancer., Nat Rev Drug Discov
ChemblInteractions: PKBG
- Version: chembl_23
Alternate Names:

PKBG GENE_SYMBOL

AKT3 GENE_SYMBOL

RAC-gamma serine/threonine-protein kinase UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000117020
- Version: 31-May-2017
Alternate Names:

ENSG00000117020 Gene Symbol

AKT3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: AKT3
- Version: 19.3
Alternate Names:

ENSG00000117020 Ensembl Gene ID

PKBG Human Protein Atlas Gene Synonym

PRKBG Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: AKT3
- Version: 01-February-2022
Alternate Names:

PKBG GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
Tempus: AKT3
- Version: 11-November-2018
Alternate Names:

AKT3 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: AKT3
- Version: 27-Jun-2013
Alternate Names:

10000 Gene ID

PKB-GAMMA dGene Synonym

PKBG dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
Pharos: AKT3
- Version: 01-February-2022
Alternate Names:

RAC-gamma serine/threonine-protein kinase Gene Name

Q9Y243 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: AKT3
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
MyCancerGenomeClinicalTrial: AKT3
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
ClearityFoundationClinicalTrial: AKT3
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
DTC: AKT3
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: AKT3
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: AKT3
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: AKT3
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Direct Interaction	yes
Mechanism of Interaction	Serine/threonine-protein kinase AKT inhibitor
Trial Name	XL418

Trial Name	GDC-0068
Novel drug target	Novel Target
Mechanism of Interaction	Serine/threonine-protein kinase AKT inhibitor

Trial Name	triciribine-phosphate, TCN-P, VQD-002
Novel drug target	Novel Target

Direct Interaction	yes
Mechanism of Interaction	Serine/threonine-protein kinase AKT3 inhibitor

ENSG00000117020	Ensembl Gene Id
AKT3_HUMAN	Uniprot Id
AKT3	Uniprot Gene Name

RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE (EC 2.7.1.37) (RAC-PK-GAMMA) (PROTEIN KINASE AKT-3) (PROTEIN KINASE B, GAMMA) (PKB GAMMA) (STK-2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y243]	Description
AKT3	Display Id
ENSG00000117020	Ensembl Gene Id

PKBG	GENE_SYMBOL
AKT3	GENE_SYMBOL
RAC-gamma serine/threonine-protein kinase	UNIPROT

RAC-gamma serine/threonine-protein kinase	Gene Name
Q9Y243	UniProt ID

allosteric modulator
inhibitor (inhibitory)

allosteric modulator
inhibitor (inhibitory)

AKT3 Gene Record

AKT3 10000 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor Trial Name XL418

PMIDs: 19644473

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name GDC-0068 Novel drug target Novel Target Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions MyCancerGenomeClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name triciribine-phosphate, TCN-P, VQD-002 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial ClearityFoundationClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: allosteric modulator inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name RX-0201,Archexin Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase AKT3 inhibitor

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: allosteric modulator inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor Direct Interaction yes Trial Name MK-2206

PMIDs: None found

Sources: TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions MyCancerGenomeClinicalTrial TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationClinicalTrial TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name perifosine, KRX-0401

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24265155

Sources: CIViC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Trial Name XL418

PMIDs:
19644473

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name GDC-0068

Novel drug target Novel Target

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name triciribine-phosphate, TCN-P, VQD-002

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

allosteric modulator

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name RX-0201,Archexin

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase AKT3 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

allosteric modulator

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Direct Interaction yes

Trial Name MK-2206

PMIDs:
None found

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions MyCancerGenomeClinicalTrial TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name perifosine, KRX-0401

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase AKT inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
24265155

Sources:
CIViC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found