DGIdb - APC Gene Record

APC 324 Clinically Actionable

Alternate Names:

324
APC, WNT SIGNALING PATHWAY REGULATOR
APC
BTPS2
DP2
DP2.5
DP3
GS
PPP1R46
611731
583
ENSG00000134982
OTTHUMG00000128806
66
APC REGULATOR OF WNT SIGNALING PATHWAY
DESMD

Gene Info:

Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

CLINICALLY ACTIONABLE

Publications:

Itano et al., 2009, Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations., Carcinogenesis
Buchanan et al., 2007, Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer., Cancer Res.
Aung et al., 2016, Testing ERBB2 p.L755S kinase domain mutation as a druggable target in a patient with advanced colorectal cancer., Cold Spring Harb Mol Case Stud
Osada et al., 2011, Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations., Cancer Res.
Lehrer et al., Elevated serum triiodothyronine (t3) in Ashkenazi Jewish prostate cancer patients carrying the I1307k allele of the APC (adenopolyposis coli) gene., Urol. Oncol.
Raja et al., 2015, Assessment of the In Vivo Activity of PI3K and MEK Inhibitors in Genetically Defined Models of Colorectal Cancer., Mol. Cancer Ther.
Nautiyal et al., 2011, Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells., Int. J. Cancer
Alferez et al., 2010, Effects of vandetanib on adenoma formation in a dextran sodium sulphate enhanced Apc(MIN/+) mouse model., Int. J. Oncol.
Gurney et al., 2012, Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors., Proc. Natl. Acad. Sci. U.S.A.
Klotz et al., 2012, The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively., J. Cell. Sci.
Thorne et al., 2010, Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α., Nat. Chem. Biol.
Loaiza-Bonilla et al., 2016, KDR Mutation as a Novel Predictive Biomarker of Exceptional Response to Regorafenib in Metastatic Colorectal Cancer., Cureus
Hassan et al., 2014, Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors., Oncotarget
Hung et al., 2010, Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment., Proc. Natl. Acad. Sci. U.S.A.
Fujishita et al., 2008, Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice., Proc. Natl. Acad. Sci. U.S.A.

PYRVINIUM APC

Interaction Score: 6.51

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
20890287

Sources:
JAX-CKB
VANTICTUMAB APC

Interaction Score: 0.93

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colon cancer

Response Type predicted – sensitive

Approval Status Preclinical - Pdx

PMIDs:
22753465

Sources:
JAX-CKB
BINIMETINIB APC

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

Response Type no benefit

Evidence Type Actionable

Approval Status Preclinical

PMIDs:
26206338

Sources:
JAX-CKB
SULINDAC APC

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
19755659

Sources:
JAX-CKB
SAPANISERTIB APC

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
25261369

Sources:
JAX-CKB
TRASTUZUMAB APC

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Fluorouracil + Leucovorin + Trastuzumab

Indication/Tumor Type rectum adenocarcinoma

Response Type no benefit

PMIDs:
27626067

Sources:
JAX-CKB
VINORELBINE APC

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colon cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
22399804

Sources:
JAX-CKB
NICLOSAMIDE APC

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
21531761

Sources:
JAX-CKB
REGORAFENIB APC

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Clinical Study

PMIDs:
27004155

Sources:
JAX-CKB
LEUCOVORIN APC

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Clinical Study

Response Type no benefit

PMIDs:
27626067

Sources:
JAX-CKB
LIOTHYRONINE SODIUM APC

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12856637

Sources:
NCI
IBUPROFEN APC

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical - Cell line xenograft

Response Type sensitive

PMIDs:
17909047

Sources:
JAX-CKB
SIROLIMUS APC

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colon cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
20080688 18768809

Sources:
JAX-CKB
DACTOLISIB APC

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy BEZ235 + Binimetinib

Indication/Tumor Type colorectal cancer

Response Type sensitive

PMIDs:
26206338

Sources:
JAX-CKB
ERLOTINIB APC

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Erlotinib + Ibuprofen

Indication/Tumor Type colorectal cancer

Response Type sensitive

PMIDs:
17909047

Sources:
JAX-CKB
VANDETANIB APC

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colon cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
20811697

Sources:
JAX-CKB
CELECOXIB APC

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
17909047

Sources:
JAX-CKB
DASATINIB APC

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
20473900

Sources:
JAX-CKB
FLUOROURACIL APC

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Fluorouracil + Leucovorin + Trastuzumab

Indication/Tumor Type rectum adenocarcinoma

Response Type no benefit

PMIDs:
27626067

Sources:
JAX-CKB

Ensembl: ENSG00000134982
- Version: 101_38
Alternate Names:

APC Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

JAX-CKB: APC

Version: 27-September-2017

Alternate Names:

324 CKB Entrez Id

APC CKB Gene Synonym

BTPS2 CKB Gene Synonym

Gene Info:

Publications:

Aung et al., 2016, Testing ERBB2 p.L755S kinase domain mutation as a druggable target in a patient with advanced colorectal cancer., Cold Spring Harb Mol Case Stud

Alferez et al., 2010, Effects of vandetanib on adenoma formation in a dextran sodium sulphate enhanced Apc(MIN/+) mouse model., Int. J. Oncol.

Klotz et al., 2012, The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively., J. Cell. Sci.

CIViC: APC

Version: 14-September-2020

Alternate Names:

324 Entrez Gene ID

66 CIViC Gene ID

Gene Info:

Publications:

Waaler et al., 2012, A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice., Cancer Res.

Lau et al., 2013, A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth., Cancer Res.

NCI: APC

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Ritland et al., 1999, Chemoprevention of intestinal adenomas in the ApcMin mouse by piroxicam: kinetics, strain effects and resistance to chemosuppression., Carcinogenesis

Krawczyk et al., 2006, Alteration of DNA methylation status in K562 and MCF-7 cancer cell lines by nucleoside analogues., Nucleosides Nucleotides Nucleic Acids

Zysman et al., 2002, Methylation of adenomatous polyposis coli in endometrial cancer occurs more frequently in tumors with microsatellite instability phenotype., Cancer Res.

Tempus: APC
- Version: 11-November-2018
Alternate Names:

APC Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
MskImpact: APC
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: APC
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: APC
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Indication/Tumor Type	colorectal cancer
Response Type	sensitive
Approval Status	Preclinical

Indication/Tumor Type	colon cancer
Response Type	predicted – sensitive
Approval Status	Preclinical - Pdx

Response Type	no benefit
Evidence Type	Actionable
Approval Status	Preclinical

combination therapy	Fluorouracil + Leucovorin + Trastuzumab
Indication/Tumor Type	rectum adenocarcinoma
Response Type	no benefit

combination therapy	BEZ235 + Binimetinib
Indication/Tumor Type	colorectal cancer
Response Type	sensitive

combination therapy	Erlotinib + Ibuprofen
Indication/Tumor Type	colorectal cancer
Response Type	sensitive

APC Gene Record

APC 324 Clinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type colorectal cancer Response Type sensitive Approval Status Preclinical

PMIDs: 20890287

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type colon cancer Response Type predicted – sensitive Approval Status Preclinical - Pdx

PMIDs: 22753465

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Response Type no benefit Evidence Type Actionable Approval Status Preclinical

PMIDs: 26206338

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Evidence Type Actionable Approval Status Preclinical Response Type sensitive

PMIDs: 19755659

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type colorectal cancer Response Type sensitive Approval Status Preclinical

PMIDs: 25261369

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: combination therapy Fluorouracil + Leucovorin + Trastuzumab Indication/Tumor Type rectum adenocarcinoma Response Type no benefit

PMIDs: 27626067

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type colon cancer Response Type sensitive Approval Status Preclinical

PMIDs: 22399804

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type colorectal cancer Response Type sensitive Approval Status Preclinical

PMIDs: 21531761

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type colorectal cancer Response Type sensitive Approval Status Clinical Study

PMIDs: 27004155

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Evidence Type Actionable Approval Status Clinical Study Response Type no benefit

PMIDs: 27626067

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12856637

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Evidence Type Actionable Approval Status Preclinical - Cell line xenograft Response Type sensitive

PMIDs: 17909047

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type colon cancer Response Type sensitive Approval Status Preclinical

PMIDs: 20080688 18768809

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: combination therapy BEZ235 + Binimetinib Indication/Tumor Type colorectal cancer Response Type sensitive

PMIDs: 26206338

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: combination therapy Erlotinib + Ibuprofen Indication/Tumor Type colorectal cancer Response Type sensitive

PMIDs: 17909047

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type colon cancer Response Type sensitive Approval Status Preclinical

PMIDs: 20811697

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type colorectal cancer Response Type sensitive Approval Status Preclinical

PMIDs: 17909047

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type colorectal cancer Response Type sensitive Approval Status Preclinical

PMIDs: 20473900

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: combination therapy Fluorouracil + Leucovorin + Trastuzumab Indication/Tumor Type rectum adenocarcinoma Response Type no benefit

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
20890287

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colon cancer

Response Type predicted – sensitive

Approval Status Preclinical - Pdx

PMIDs:
22753465

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Response Type no benefit

Evidence Type Actionable

Approval Status Preclinical

PMIDs:
26206338

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
19755659

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
25261369

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Fluorouracil + Leucovorin + Trastuzumab

Indication/Tumor Type rectum adenocarcinoma

Response Type no benefit

PMIDs:
27626067

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colon cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
22399804

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
21531761

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Clinical Study

PMIDs:
27004155

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Clinical Study

Response Type no benefit

PMIDs:
27626067

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
12856637

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical - Cell line xenograft

Response Type sensitive

PMIDs:
17909047

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colon cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
20080688 18768809

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy BEZ235 + Binimetinib

Indication/Tumor Type colorectal cancer

Response Type sensitive

PMIDs:
26206338

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Erlotinib + Ibuprofen

Indication/Tumor Type colorectal cancer

Response Type sensitive

PMIDs:
17909047

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colon cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
20811697

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
17909047

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
20473900

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Fluorouracil + Leucovorin + Trastuzumab

Indication/Tumor Type rectum adenocarcinoma

Response Type no benefit

PMIDs:
27626067

Sources:
JAX-CKB

Alternate Names:

APC Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

324 CKB Entrez Id

APC CKB Gene Synonym

BTPS2 CKB Gene Synonym

Alternate Names:

324 Entrez Gene ID

66 CIViC Gene ID

Alternate Names:

APC Gene Symbol