DGIdb - APH1A Gene Record

APH1A 51107 Druggable GenomeClinically Actionable

Alternate Names:

51107
APH-1 HOMOLOG A, GAMMA-SECRETASE SUBUNIT
APH1A
6530402N02Rik
APH-1
APH-1A
CGI-78
607629
29509
ENSG00000117362
OTTHUMG00000012545
PSF
Q96BI3
UNQ579/PRO1141
Gamma-secretase
Presenilin-stabilization factor
Aph-1alpha
Gamma-secretase subunit APH-1A
Gamma-secretase subunit APH-1A/1B
T05880

Gene Info:

Target Class	Enzymes
Target Subclass	Miscellaneous:Gamma secretase subunit
Target Subclass	APH-1 family
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Pu J et al., 2009, Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors., Bioorg Med Chem
Höttecke N et al., 2010, Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta., Bioorg Med Chem Lett
Liu Y et al., 2012, Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases., J Med Chem

CHEMBL392068 APH1A

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23181502 19443228

Sources:
DTC
MK-0752 APH1A

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial
SEMAGACESTAT APH1A

Interaction Score: 2.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Gamma-secretase inhibitor

Direct Interaction yes

PMIDs:
19443228

Sources:
DTC ChemblInteractions
METHYLINOSITOL APH1A

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name NIC5-15

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
AVAGACESTAT APH1A

Interaction Score: 1.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gamma-secretase inhibitor

Trial Name BMS-708163

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
IC261 APH1A

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20350806

Sources:
DTC
GSI-136 APH1A

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GSI-136

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
BEGACESTAT APH1A

Interaction Score: 1.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Gamma-secretase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL247471 APH1A

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-299897

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
TARENFLURBIL APH1A

Interaction Score: 0.69

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gamma-secretase modulator

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000117362
- Version: 101_38
Alternate Names:

APH1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q96BI3
- Version: January-2014
Alternate Names:

APH1A Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass Miscellaneous:Gamma secretase subunit

Target Subclass APH-1 family

Publications:

DTC: APH1A

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Pu J et al., 2009, Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors., Bioorg Med Chem

Höttecke N et al., 2010, Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta., Bioorg Med Chem Lett

Liu Y et al., 2012, Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases., J Med Chem

HingoraniCasas: ENSG00000117362
- Version: 31-May-2017
Alternate Names:

ENSG00000117362 Gene Symbol

APH1A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: APH-1
- Version: 12-May-2016
Alternate Names:

APH-1 Gene Symbol

Gene Info:

Publications:
MyCancerGenome: APH1A
- Version: 20-Jun-2017
Alternate Names:

51107 Entrez Gene Id

APH1A MyCancerGenome Gene Symbol

Gamma-secretase MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: PSF
- Version: chembl_23
Alternate Names:

PSF GENE_SYMBOL

UNQ579/PRO1141 GENE_SYMBOL

APH1A GENE_SYMBOL

Gene Info:

Publications:
TTD: Gamma-secretase subunit APH-1A/1B
- Version: 2020.06.01
Alternate Names:

APH-1 TTD Gene Abbreviation

T05880 TTD Target ID

Gene Info:

Publications:
ClearityFoundationClinicalTrial: APH1A
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: APH1A
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Gamma-secretase inhibitor
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Gamma-secretase modulator

51107	Entrez Gene Id
APH1A	MyCancerGenome Gene Symbol
Gamma-secretase	MyCancerGenome Reported Gene Name

Trial Name	NIC5-15
Novel drug target	Novel Target

Trial Name	GSI-136
Novel drug target	Novel Target

Trial Name	BMS-299897
Novel drug target	Novel Target

APH1A Gene Record

APH1A 51107 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23181502 19443228

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Gamma-secretase inhibitor Direct Interaction yes

PMIDs: 19443228

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name NIC5-15 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Gamma-secretase inhibitor Trial Name BMS-708163

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20350806

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name GSI-136 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Gamma-secretase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name BMS-299897 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Gamma-secretase modulator

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000117362

Alternate Names: APH1A Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q96BI3

Alternate Names: APH1A Gene Symbol

Gene Info: Target Class Enzymes Target Subclass Miscellaneous:Gamma secretase subunit Target Subclass APH-1 family

Publications:

DTC: APH1A

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000117362

Alternate Names: ENSG00000117362 Gene Symbol APH1A Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TALC: APH-1

Alternate Names: APH-1 Gene Symbol

Gene Info:

Publications:

MyCancerGenome: APH1A

Alternate Names: 51107 Entrez Gene Id APH1A MyCancerGenome Gene Symbol Gamma-secretase MyCancerGenome Reported Gene Name

Gene Info:

Publications:

ChemblInteractions: PSF

Alternate Names: PSF GENE_SYMBOL UNQ579/PRO1141 GENE_SYMBOL APH1A GENE_SYMBOL

Gene Info:

Publications:

TTD: Gamma-secretase subunit APH-1A/1B

Alternate Names: APH-1 TTD Gene Abbreviation T05880 TTD Target ID

Gene Info:

Publications:

ClearityFoundationClinicalTrial: APH1A

Alternate Names:

Interaction Types & Directionality:

n/a

PMIDs:
23181502 19443228

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Gamma-secretase inhibitor

Direct Interaction yes

PMIDs:
19443228

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name NIC5-15

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gamma-secretase inhibitor

Trial Name BMS-708163

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20350806

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GSI-136

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Gamma-secretase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-299897

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gamma-secretase modulator

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

APH1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

APH1A Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass Miscellaneous:Gamma secretase subunit

Target Subclass APH-1 family

Alternate Names:

ENSG00000117362 Gene Symbol

APH1A Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

APH-1 Gene Symbol

Alternate Names:

51107 Entrez Gene Id

APH1A MyCancerGenome Gene Symbol

Gamma-secretase MyCancerGenome Reported Gene Name

Alternate Names:

PSF GENE_SYMBOL

UNQ579/PRO1141 GENE_SYMBOL

APH1A GENE_SYMBOL

Alternate Names:

APH-1 TTD Gene Abbreviation

T05880 TTD Target ID

Gene Categories:

CLINICALLY ACTIONABLE