DGIdb - APH1B Gene Record

APH1B 83464 Druggable Genome

Alternate Names:

83464
APH-1 HOMOLOG B, GAMMA-SECRETASE SUBUNIT
APH1B
APH-1B
PRO1328
PSFL
TAAV688
607630
24080
ENSG00000138613
OTTHUMG00000132863
Presenilin-stabilization factor-like
Aph-1beta
Gamma-secretase subunit APH-1B
Gamma-secretase
Q8WW43

Gene Info:

Target Class	Enzymes
Target Subclass	Miscellaneous:Gamma secretase subunit
Target Subclass	APH-1 family
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME

Publications:

Liu Y et al., 2012, Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases., J Med Chem
Pu J et al., 2009, Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors., Bioorg Med Chem
Höttecke N et al., 2010, Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta., Bioorg Med Chem Lett

MK-0752 APH1B

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial
CHEMBL392068 APH1B

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23181502 19443228

Sources:
DTC
SEMAGACESTAT APH1B

Interaction Score: 2.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Gamma-secretase inhibitor

Direct Interaction yes

PMIDs:
19443228

Sources:
DTC ChemblInteractions
IC261 APH1B

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20350806

Sources:
DTC
AVAGACESTAT APH1B

Interaction Score: 1.96

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gamma-secretase inhibitor

Trial Name BMS-708163

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
CHEMBL247471 APH1B

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-299897

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
BEGACESTAT APH1B

Interaction Score: 1.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gamma-secretase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
GSI-136 APH1B

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GSI-136

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
TARENFLURBIL APH1B

Interaction Score: 0.76

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gamma-secretase modulator

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000138613
- Version: 101_38
Alternate Names:

APH1B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q8WW43
- Version: January-2014
Alternate Names:

APH1B Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass Miscellaneous:Gamma secretase subunit

Target Subclass APH-1 family

Publications:

DTC: APH1B

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Liu Y et al., 2012, Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases., J Med Chem

Pu J et al., 2009, Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors., Bioorg Med Chem

Höttecke N et al., 2010, Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta., Bioorg Med Chem Lett

MyCancerGenome: APH1B
- Version: 20-Jun-2017
Alternate Names:

83464 Entrez Gene Id

APH1B MyCancerGenome Gene Symbol

Gamma-secretase MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: PSFL
- Version: chembl_23
Alternate Names:

PSFL GENE_SYMBOL

APH1B GENE_SYMBOL

Gamma-secretase subunit APH-1B UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000138613
- Version: 31-May-2017
Alternate Names:

ENSG00000138613 Gene Symbol

APH1B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: APH1B
- Version: 27-Jun-2013
Alternate Names:

83464 Gene ID

APH-1B dGene Synonym

PRO1328 dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
ClearityFoundationClinicalTrial: APH1B
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Mechanism of Interaction	Gamma-secretase inhibitor
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Gamma-secretase modulator

83464	Entrez Gene Id
APH1B	MyCancerGenome Gene Symbol
Gamma-secretase	MyCancerGenome Reported Gene Name

PSFL	GENE_SYMBOL
APH1B	GENE_SYMBOL
Gamma-secretase subunit APH-1B	UNIPROT

Trial Name	BMS-299897
Novel drug target	Novel Target

Trial Name	GSI-136
Novel drug target	Novel Target

APH1B Gene Record

APH1B 83464 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23181502 19443228

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Gamma-secretase inhibitor Direct Interaction yes

PMIDs: 19443228

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20350806

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Gamma-secretase inhibitor Trial Name BMS-708163

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name BMS-299897 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Gamma-secretase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name GSI-136 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Gamma-secretase modulator

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000138613

Alternate Names: APH1B Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q8WW43

Alternate Names: APH1B Gene Symbol

Gene Info: Target Class Enzymes Target Subclass Miscellaneous:Gamma secretase subunit Target Subclass APH-1 family

Publications:

DTC: APH1B

Alternate Names:

Gene Info:

MyCancerGenome: APH1B

Alternate Names: 83464 Entrez Gene Id APH1B MyCancerGenome Gene Symbol Gamma-secretase MyCancerGenome Reported Gene Name

Gene Info:

Publications:

ChemblInteractions: PSFL

Alternate Names: PSFL GENE_SYMBOL APH1B GENE_SYMBOL Gamma-secretase subunit APH-1B UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000138613

Alternate Names: ENSG00000138613 Gene Symbol APH1B Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

dGene: APH1B

Alternate Names: 83464 Gene ID APH-1B dGene Synonym PRO1328 dGene Synonym

Gene Info:

Gene Categories: PROTEASE

Publications:

ClearityFoundationClinicalTrial: APH1B

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
23181502 19443228

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Gamma-secretase inhibitor

Direct Interaction yes

PMIDs:
19443228

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20350806

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gamma-secretase inhibitor

Trial Name BMS-708163

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-299897

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gamma-secretase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GSI-136

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Gamma-secretase modulator

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

APH1B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

APH1B Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass Miscellaneous:Gamma secretase subunit

Target Subclass APH-1 family

Alternate Names:

83464 Entrez Gene Id

APH1B MyCancerGenome Gene Symbol

Gamma-secretase MyCancerGenome Reported Gene Name

Alternate Names:

PSFL GENE_SYMBOL

APH1B GENE_SYMBOL

Gamma-secretase subunit APH-1B UNIPROT

Alternate Names:

ENSG00000138613 Gene Symbol

APH1B Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

83464 Gene ID

APH-1B dGene Synonym

PRO1328 dGene Synonym

Gene Categories:

PROTEASE