351 |
AMYLOID BETA PRECURSOR PROTEIN |
APP |
AAA |
ABETA |
ABPP |
AD1 |
APPI |
CTFgamma |
CVAP |
PN-II |
PN2 |
preA4 |
104760 |
620 |
ENSG00000142192 |
OTTHUMG00000078438 |
P05067 |
Amyloid intracellular domain 59 |
Beta-APP40 |
Beta-APP42 |
Protease nexin-II |
Cerebral vascular amyloid peptide |
Beta-amyloid precursor protein |
Alzheimer disease amyloid protein |
C31 |
Gamma-secretase C-terminal fragment 50 |
Gamma-secretase C-terminal fragment 57 |
Gamma-secretase C-terminal fragment 59 |
Amyloid precursor protein |
Gamma-CTF(50) |
Amyloid intracellular domain 50 |
Gamma-CTF(57) |
Amyloid intracellular domain 57 |
Gamma-CTF(59) |
C80 |
P3(40) |
P3(42) |
C83 |
Beta-amyloid protein 40 |
S-APP-alpha |
Beta-amyloid protein 42 |
C99 |
AID(50) |
Soluble APP-beta |
Soluble APP-alpha |
N-APP |
Amyloid beta A4 protein |
S-APP-beta |
AICD-59 |
AID(59) |
AICD-57 |
AID(57) |
AICD-50 |
A4 |
T87024 |
alpha-sAPP |
Target Class | Miscellaneous |
Target Subclass | Miscellaneous:Amyloid beta 4 |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
PROTEASE INHIBITOR |
DRUGGABLE GENOME |
n/a |
Trial Name | Bapineuzumab |
Novel drug target | Novel Target |
Mechanism of Interaction | Beta amyloid A4 protein other |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | Beta amyloid A4 protein other |
Novel drug target | Novel Target |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Beta amyloid A4 protein inhibitor |
Trial Name | BAN2401 |
n/a |
Mechanism of Interaction | Beta amyloid A4 protein other |
Direct Interaction | yes |
Novel drug target | Novel Target |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | Beta amyloid A4 protein other |
n/a |
Novel drug target | Novel Target |
Trial Name | MABT5102A |
Mechanism of Interaction | Beta amyloid A4 protein other |
n/a |
Trial Name | HuCAL anti-beta amyloid monoclonal antibody |
Novel drug target | Novel Target |
Mechanism of Interaction | Beta amyloid A4 protein other |
n/a |
Novel drug target | Novel Target |
Trial Name | Scyllo-inositol, ELND005, AZD-103 |
n/a |
Trial Name | Caprospinol , SP-233 |
Novel drug target | Novel Target |
n/a |
Trial Name | ACC-001, Alzheimer's vaccine |
Novel drug target | Novel Target |
n/a |
Mechanism of Interaction | Beta amyloid A4 protein other |
Direct Interaction | yes |
n/a |
Trial Name | Posiphen |
Novel drug target | Novel Target |
Trial Name | [(+)-phenserine tartrate,Posiphen |
APP | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
APP | Gene Symbol |
Target Class | Miscellaneous |
Target Subclass | Miscellaneous:Amyloid beta 4 |
APP | TTD Gene Abbreviation |
T87024 | TTD Target ID |
ENSG00000142192 | Gene Symbol |
APP | Ensembl Id |
DRUGGABLE GENOME |
AD1 | GENE_SYMBOL |
APP | GENE_SYMBOL |
Amyloid beta A4 protein | UNIPROT |
A4 | GO Gene Synonym |
AD1 | GO Gene Synonym |
CELL SURFACE |
351 | Gene ID |
AAA | dGene Synonym |
ABETA | dGene Synonym |
PROTEASE INHIBITOR |