DGIdb - ATRX Gene Record

ATRX 546 Clinically Actionable

Alternate Names:

546
ATRX, CHROMATIN REMODELER
ATRX
JMS
MRX52
RAD54
RAD54L
XH2
XNP
ZNF-HX
300032
300504
886
ENSG00000085224
OTTHUMG00000022686
P46100
525
ATRX CHROMATIN REMODELER

Gene Info:

Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

DNA REPAIR
CLINICALLY ACTIONABLE
ENZYME

Publications:

Kim et al., 2016, Gemcitabine Plus Radiation Therapy for High-Grade Glioma: Long-Term Results of a Phase 1 Dose-Escalation Study., Int. J. Radiat. Oncol. Biol. Phys.
Koschmann et al., 2016, ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma., Sci Transl Med
Wiestler et al., 2013, ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis., Acta Neuropathol.
McGonigle et al., 2015, E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling., Oncotarget

LOMUSTINE ATRX

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23904111

Sources:
CIViC
PROCARBAZINE ATRX

Interaction Score: 2.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23904111

Sources:
CIViC
2X-121 ATRX

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Preclinical

PMIDs:
26513298

Sources:
JAX-CKB
TOPOTECAN ATRX

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
26936505

Sources:
JAX-CKB
TEMOZOLOMIDE ATRX

Interaction Score: 0.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23904111

Sources:
CIViC
IRINOTECAN ATRX

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type glioblastoma multiforme

Response Type sensitive

Approval Status Preclinical

PMIDs:
26936505

Sources:
JAX-CKB
VINCRISTINE ATRX

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23904111

Sources:
CIViC
GEMCITABINE ATRX

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Gemcitabine + Radiotherapy

Indication/Tumor Type malignant glioma

Response Type predicted – sensitive

PMIDs:
26853339

Sources:
JAX-CKB
DOXORUBICIN ATRX

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Approval Status Preclinical

Indication/Tumor Type glioblastoma multiforme

Response Type sensitive

PMIDs:
26936505

Sources:
JAX-CKB

Ensembl: ENSG00000085224
- Version: 101_38
Alternate Names:

ATRX Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

JAX-CKB: ATRX

Version: 27-September-2017

Alternate Names:

546 CKB Entrez Id

ATRX CKB Gene Synonym

JMS CKB Gene Synonym

Gene Info:

Publications:

Kim et al., 2016, Gemcitabine Plus Radiation Therapy for High-Grade Glioma: Long-Term Results of a Phase 1 Dose-Escalation Study., Int. J. Radiat. Oncol. Biol. Phys.

Koschmann et al., 2016, ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma., Sci Transl Med

McGonigle et al., 2015, E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling., Oncotarget

CIViC: ATRX

Version: 14-September-2020

Alternate Names:

546 Entrez Gene ID

525 CIViC Gene ID

Gene Info:

Publications:

Flynn RL et al., 2015, Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors., Science

Wiestler et al., 2013, ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis., Acta Neuropathol.

HumanProteinAtlas: ATRX
- Version: 19.3
Alternate Names:

ENSG00000085224 Ensembl Gene ID

JMS Human Protein Atlas Gene Synonym

MRX52 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: ATRX
- Version: 01-February-2022
Alternate Names:

RAD54L GO Gene Synonym

XH2 GO Gene Synonym

Gene Info:

Gene Categories:

DNA REPAIR

Publications:
Tempus: ATRX
- Version: 11-November-2018
Alternate Names:

ATRX Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
MskImpact: ATRX
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: ATRX
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: ATRX
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: ATRX
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Indication/Tumor Type	Advanced Solid Tumor
Response Type	sensitive
Approval Status	Preclinical

Evidence Type	Actionable
Approval Status	Preclinical
Response Type	sensitive

Indication/Tumor Type	glioblastoma multiforme
Response Type	sensitive
Approval Status	Preclinical

combination therapy	Gemcitabine + Radiotherapy
Indication/Tumor Type	malignant glioma
Response Type	predicted – sensitive

ENSG00000085224	Ensembl Gene ID
JMS	Human Protein Atlas Gene Synonym
MRX52	Human Protein Atlas Gene Synonym

ATRX Gene Record

ATRX 546 Clinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23904111

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23904111

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type Advanced Solid Tumor Response Type sensitive Approval Status Preclinical

PMIDs: 26513298

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Evidence Type Actionable Approval Status Preclinical Response Type sensitive

PMIDs: 26936505

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23904111

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type glioblastoma multiforme Response Type sensitive Approval Status Preclinical

PMIDs: 26936505

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23904111

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info: combination therapy Gemcitabine + Radiotherapy Indication/Tumor Type malignant glioma Response Type predicted – sensitive

PMIDs: 26853339

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Approval Status Preclinical Indication/Tumor Type glioblastoma multiforme Response Type sensitive

PMIDs: 26936505

Sources: JAX-CKB

Ensembl: ENSG00000085224

Alternate Names: ATRX Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

JAX-CKB: ATRX

Alternate Names: 546 CKB Entrez Id ATRX CKB Gene Synonym JMS CKB Gene Synonym

Gene Info:

CIViC: ATRX

Alternate Names: 546 Entrez Gene ID 525 CIViC Gene ID

Gene Info:

HumanProteinAtlas: ATRX

Alternate Names: ENSG00000085224 Ensembl Gene ID JMS Human Protein Atlas Gene Synonym MRX52 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

GO: ATRX

Alternate Names: RAD54L GO Gene Synonym XH2 GO Gene Synonym

Gene Info:

Gene Categories: DNA REPAIR

Publications:

Tempus: ATRX

Alternate Names: ATRX Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

MskImpact: ATRX

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

FoundationOneGenes: ATRX

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

CarisMolecularIntelligence: ATRX

Alternate Names:

Gene Info:

Interaction Types & Directionality:

n/a

PMIDs:
23904111

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
23904111

Sources:
CIViC

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Preclinical

PMIDs:
26513298

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
26936505

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
23904111

Sources:
CIViC

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type glioblastoma multiforme

Response Type sensitive

Approval Status Preclinical

PMIDs:
26936505

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
23904111

Sources:
CIViC

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Gemcitabine + Radiotherapy

Indication/Tumor Type malignant glioma

Response Type predicted – sensitive

PMIDs:
26853339

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Approval Status Preclinical

Indication/Tumor Type glioblastoma multiforme

Response Type sensitive

PMIDs:
26936505

Sources:
JAX-CKB

Alternate Names:

ATRX Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

546 CKB Entrez Id

ATRX CKB Gene Synonym

JMS CKB Gene Synonym

Alternate Names:

546 Entrez Gene ID

525 CIViC Gene ID

Alternate Names:

ENSG00000085224 Ensembl Gene ID

JMS Human Protein Atlas Gene Synonym

MRX52 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

RAD54L GO Gene Synonym

XH2 GO Gene Synonym

Gene Categories:

DNA REPAIR

Alternate Names:

ATRX Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE