DGIdb - CACNA2D1 Gene Record

CACNA2D1 781 Druggable Genome

Alternate Names:

781
CALCIUM VOLTAGE-GATED CHANNEL AUXILIARY SUBUNIT ALPHA2DELTA 1
CACNA2D1
CACNA2
CACNL2A
CCHL2A
LINC01112
lncRNA-N3
114204
1399
ENSG00000153956
OTTHUMG00000023622
P54289
CA2D1_HUMAN
Voltage-dependent calcium channel subunit alpha-2-1
Voltage-dependent calcium channel subunit alpha-2/delta-1
Voltage-gated calcium channel subunit alpha-2/delta-1
MHS3
Voltage-dependent calcium channel subunit delta-1
DIHYDROPYRIDINE-SENSITIVE L-TYPE, CALCIUM CHANNEL ALPHA-2/DELTA SUBUNITS PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P54289]
PA86
Voltage-gated calcium channel alpha-2/delta-1
T84316

Gene Info:

Target Subclass	AuxillaryTransportUnit
Target Subclass	CACNA2D
Transmembrane Helix Count	1
Target Main Class	Transporters
Human Readable Name	DRUGGABLE GENOME
Target Class	Transporters
Target Subclass	TC:8.A.18.1.1
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Hota et al., 2007, Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study., Methods Find Exp Clin Pharmacol
Hoffmann et al., 2010, Gabapentin suppresses cortical spreading depression susceptibility., J. Cereb. Blood Flow Metab.
Hendrich et al., 2008, Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin., Proc. Natl. Acad. Sci. U.S.A.
Maneuf et al., 2006, alpha2delta and the mechanism of action of gabapentin in the treatment of pain., Semin. Cell Dev. Biol.
Gazulla et al., 2007, The P/Q-type voltage-dependent calcium channel as pharmacological target in spinocerebellar ataxia type 6: gabapentin and pregabalin may be of therapeutic benefit., Med. Hypotheses
Kukkar A et al., 2013, Implications and mechanism of action of gabapentin in neuropathic pain., Arch Pharm Res
Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Zahradníková et al., 2007, Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists., J. Pharmacol. Exp. Ther.
Furukawa et al., 1999, Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes., J. Pharmacol. Exp. Ther.
Li et al., 2006, Ion channels in mesenchymal stem cells from rat bone marrow., Stem Cells
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Doggrell et al., 2005, Ibutilide--recent molecular insights and accumulating evidence for use in atrial flutter and fibrillation., Expert Opin Investig Drugs
Foster et al., 1997, Ibutilide. A review of its pharmacological properties and clinical potential in the acute management of atrial flutter and fibrillation., Drugs
Verma V et al., 2014, Pregabalin in neuropathic pain: evidences and possible mechanisms., Curr Neuropharmacol

MIROGABALIN CACNA2D1

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
IBUTILIDE CACNA2D1

Interaction Score: 2.75

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15926871 9257085

Sources:
TdgClinicalTrial TEND
ISRADIPINE CACNA2D1

Interaction Score: 2.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND
MIROGABALIN BESYLATE CACNA2D1

Interaction Score: 1.72

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel alpha2/delta subunit 1 modulator

PMIDs:
None found

Sources:
ChemblInteractions
NITRENDIPINE CACNA2D1

Interaction Score: 1.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11752352

Sources:
TTD
FELODIPINE CACNA2D1

Interaction Score: 1.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

PMIDs:
17475903 10525060 11752352

Sources:
TdgClinicalTrial TEND
GABAPENTIN CACNA2D1

Interaction Score: 1.1

Interaction Types & Directionality:

inhibitor (inhibitory)

modulator

Interaction Info:

Trial Name Depomed

Novel drug target Established target

Trial Name gabapentin,N/

PMIDs:
17982508 20588320 18299583 17067834 16899342 23435945

Sources:
TdgClinicalTrial ChemblInteractions TEND
LERCANIDIPINE CACNA2D1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AMLODIPINE CACNA2D1

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name aliskiren + amlodipine,Tekamlo

Novel drug target Established target

Trial Name amlodipine besylate,Norvasc

PMIDs:
11752352

Sources:
TdgClinicalTrial TTD
PREGABALIN CACNA2D1

Interaction Score: 0.41

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
24533015

Sources:
ChemblInteractions TTD
DILTIAZEM CACNA2D1

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NIFEDIPINE CACNA2D1

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16484345 11752352

Sources:
TdgClinicalTrial TEND
GABAPENTIN ENACARBIL CACNA2D1

Interaction Score: 0.27

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

Trial Name XP13512

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
IMAGABALIN CACNA2D1

Interaction Score: 0.27

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions TTD
SAFINAMIDE CACNA2D1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
BEPRIDIL HYDROCHLORIDE CACNA2D1

Interaction Score: 0.14

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ATAGABALIN CACNA2D1

Interaction Score: 0.14

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions
CELECOXIB CACNA2D1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB

Ensembl: ENSG00000153956
- Version: 101_38
Alternate Names:

CACNA2D1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P54289
- Version: 01-August-2011
Alternate Names:

781 Entrez Gene Id

P54289 Uniprot Accession

CACNA2D1 Gene Symbol

Gene Info:

Target Subclass AuxillaryTransportUnit

Target Subclass CACNA2D

Transmembrane Helix Count 1

Publications:

RussLampel: ENSG00000153956

Version: 26-July-2011

Alternate Names:

CACNA2D1 Display Id

ENSG00000153956 Ensembl Gene Id

DIHYDROPYRIDINE-SENSITIVE L-TYPE, CALCIUM CHANNEL ALPHA-2/DELTA SUBUNITS PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P54289] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P54289
- Version: January-2014
Alternate Names:

CACNA2D1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:8.A.18.1.1

Publications:
PharmGKB: CACNA2D1
- Version: 18-August-2020
Alternate Names:

PA86 PharmGKB ID

Gene Info:

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
HingoraniCasas: ENSG00000153956
- Version: 31-May-2017
Alternate Names:

ENSG00000153956 Gene Symbol

CACNA2D1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CACNL2A
- Version: chembl_23
Alternate Names:

CCHL2A GENE_SYMBOL

MHS3 GENE_SYMBOL

CACNA2D1 GENE_SYMBOL

Gene Info:

Publications:
TTD: Voltage-gated calcium channel alpha-2/delta-1
- Version: 2020.06.01
Alternate Names:

CACNA2D1 TTD Gene Abbreviation

T84316 TTD Target ID

Gene Info:

Publications:
Pharos: CACNA2D1
- Version: 01-February-2022
Alternate Names:

Voltage-dependent calcium channel subunit alpha-2/delta-1 Gene Name

P54289 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Direct Interaction	yes
Mechanism of Interaction	Voltage-gated calcium channel alpha2/delta subunit 1 modulator

Trial Name	enalapril + felodipine,Lexxel
Novel drug target	Established target
Trial Name	felodipine ,Plendil

Trial Name	Depomed
Novel drug target	Established target
Trial Name	gabapentin,N/

Trial Name	aliskiren + amlodipine,Tekamlo
Novel drug target	Established target
Trial Name	amlodipine besylate,Norvasc

Mechanism of Interaction	Voltage-gated calcium channel modulator
Direct Interaction	yes

Mechanism of Interaction	Voltage-gated calcium channel blocker
Direct Interaction	yes

CACNA2D1	Display Id
ENSG00000153956	Ensembl Gene Id
DIHYDROPYRIDINE-SENSITIVE L-TYPE, CALCIUM CHANNEL ALPHA-2/DELTA SUBUNITS PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P54289]	Description

Voltage-dependent calcium channel subunit alpha-2/delta-1	Gene Name
P54289	UniProt ID

inhibitor (inhibitory)
modulator

CACNA2D1 Gene Record

CACNA2D1 781 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: activator (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 15926871 9257085

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated calcium channel alpha2/delta subunit 1 modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 11752352

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name enalapril + felodipine,Lexxel Novel drug target Established target Trial Name felodipine ,Plendil

PMIDs: 17475903 10525060 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory) modulator

Interaction Info: Trial Name Depomed Novel drug target Established target Trial Name gabapentin,N/

PMIDs: 17982508 20588320 18299583 17067834 16899342 23435945

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name aliskiren + amlodipine,Tekamlo Novel drug target Established target Trial Name amlodipine besylate,Norvasc

PMIDs: 11752352

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: 24533015

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 16484345 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes Trial Name XP13512

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Ensembl: ENSG00000153956

Alternate Names: CACNA2D1 Ensembl Gene Name

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
15926871 9257085

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel alpha2/delta subunit 1 modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
11752352

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

PMIDs:
17475903 10525060 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

modulator

Interaction Info:

Trial Name Depomed

Novel drug target Established target

Trial Name gabapentin,N/

PMIDs:
17982508 20588320 18299583 17067834 16899342 23435945

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name aliskiren + amlodipine,Tekamlo

Novel drug target Established target

Trial Name amlodipine besylate,Norvasc

PMIDs:
11752352

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
24533015

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
16484345 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

Trial Name XP13512

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Alternate Names:

CACNA2D1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

781 Entrez Gene Id

P54289 Uniprot Accession

CACNA2D1 Gene Symbol

Gene Info:

Target Subclass AuxillaryTransportUnit

Target Subclass CACNA2D

Transmembrane Helix Count 1

Alternate Names:

CACNA2D1 Display Id

ENSG00000153956 Ensembl Gene Id

DIHYDROPYRIDINE-SENSITIVE L-TYPE, CALCIUM CHANNEL ALPHA-2/DELTA SUBUNITS PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P54289] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CACNA2D1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:8.A.18.1.1

Alternate Names:

PA86 PharmGKB ID

Publications:

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

Alternate Names:

ENSG00000153956 Gene Symbol

CACNA2D1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME