DGIdb - CALCA Gene Record

CALCA 796 Druggable Genome

Alternate Names:

796
CALCITONIN RELATED POLYPEPTIDE ALPHA
CALCA
CALC1
CGRP
CGRP-I
CGRP1
CT
KC
PCT
114130
1437
ENSG00000110680
OTTHUMG00000159731
CALCITONIN GENE-RELATED PEPTIDE 1
ALPHA-TYPE CGRP
CALCITONIN GENE-RELATED PEPTIDE I
PA26029
Potassium channel unspecific
T67952
T93509
CGRP-alpha

Gene Info:

Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

HORMONE ACTIVITY
DRUGGABLE GENOME

Publications:

Dodick DW et al., 2014, Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: a randomised, double-blind, placebo-controlled, exploratory phase 2 trial., Lancet Neurol
Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.
Wu et al., 1998, [Clinical study on improving effect of Buyang Huanwu decoction on plasma thromboxane B2, 6-keto-prostaglandin F1 alpha, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients]., Zhongguo Zhong Xi Yi Jie He Za Zhi

CIZOLIRTINE CALCA

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AZIMILIDE CALCA

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL42661 CALCA

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BIMAKALIM CALCA

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL1563246 CALCA

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AMIFAMPRIDINE CALCA

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ANDOLAST CALCA

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
EPTINEZUMAB CALCA

Interaction Score: 1.47

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Calcitonin gene-related peptide_UNCURATED inhibitor

Direct Interaction yes

PMIDs:
25297013

Sources:
ChemblInteractions
AZD7009 CALCA

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BUDIODARONE CALCA

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PINACIDIL CALCA

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
IBUTILIDE CALCA

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
RANITIDINE CALCA

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12495560

Sources:
NCI
DRONEDARONE CALCA

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NATEGLINIDE CALCA

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MINOXIDIL CALCA

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DOFETILIDE CALCA

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIAZOXIDE CALCA

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PREDNISONE CALCA

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11475715

Sources:
NCI
AMIODARONE CALCA

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DALFAMPRIDINE CALCA

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000110680
- Version: 101_38
Alternate Names:

CALCA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TTD: Potassium channel unspecific
- Version: 2020.06.01
Alternate Names:

KC TTD Gene Abbreviation

T67952 TTD Target ID

Gene Info:

Publications:

Dincer UD, 2012, Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?, Diabetes Metab Syndr Obes

NCI: CALCA

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.

Shi et al., 2005, [Effect of testosterone propionate on the distribution pattern of calcitonin gene-related peptide in different motoneuron pools]., Zhongguo Yi Xue Ke Xue Yuan Xue Bao

Wu et al., 1998, [Clinical study on improving effect of Buyang Huanwu decoction on plasma thromboxane B2, 6-keto-prostaglandin F1 alpha, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients]., Zhongguo Zhong Xi Yi Jie He Za Zhi

HingoraniCasas: ENSG00000110680
- Version: 31-May-2017
Alternate Names:

ENSG00000110680 Gene Symbol

CALCA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CALC1
- Version: chembl_23
Alternate Names:

CALC1 GENE_SYMBOL

CALCA GENE_SYMBOL

Calcitonin gene-related peptide 1 UNIPROT

Gene Info:

Publications:
PharmGKB: CALCA
- Version: 18-August-2020
Alternate Names:

PA26029 PharmGKB ID

Gene Info:

Publications:
GO: CALCA
- Version: 01-February-2022
Alternate Names:

CALC1 GO Gene Synonym

Gene Info:

Gene Categories:

HORMONE ACTIVITY

Publications:
TTD: Calcitonin gene-related peptide 1
- Version: 2020.06.01
Alternate Names:

CALCA TTD Gene Abbreviation

T93509 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Calcitonin gene-related peptide_UNCURATED inhibitor
Direct Interaction	yes

CALC1	GENE_SYMBOL
CALCA	GENE_SYMBOL
Calcitonin gene-related peptide 1	UNIPROT

antibody (inhibitory)
inhibitor (inhibitory)

CALCA Gene Record

CALCA 796 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Calcitonin gene-related peptide_UNCURATED inhibitor Direct Interaction yes

PMIDs: 25297013

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12495560

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Calcitonin gene-related peptide_UNCURATED inhibitor

Direct Interaction yes

PMIDs:
25297013

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
12495560

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
11475715

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

CALCA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

KC TTD Gene Abbreviation

T67952 TTD Target ID

Publications:

Dincer UD, 2012, Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?, Diabetes Metab Syndr Obes

Alternate Names:

ENSG00000110680 Gene Symbol

CALCA Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CALC1 GENE_SYMBOL

CALCA GENE_SYMBOL

Calcitonin gene-related peptide 1 UNIPROT

Alternate Names:

PA26029 PharmGKB ID

Alternate Names:

CALC1 GO Gene Synonym

Gene Categories:

HORMONE ACTIVITY

Alternate Names:

CALCA TTD Gene Abbreviation

T93509 TTD Target ID