DGIdb - CBL Gene Record

CBL 867 Clinically Actionable

Alternate Names:

867
CBL PROTO-ONCOGENE
CBL
C-CBL
CBL2
FRA11B
NSLL
RNF55
165360
1541
ENSG00000110395
OTTHUMG00000166170
P22681
778
E3 ubiquitin-protein ligase CBL

Gene Info:

Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

KINASE
CLINICALLY ACTIONABLE
ENZYME

Publications:

William et al., 2016, Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders., Hematology
Kadera et al., 2015, Low expression of the E3 ubiquitin ligase CBL confers chemoresistance in human pancreatic cancer and is targeted by epidermal growth factor receptor inhibition., Clin. Cancer Res.
Javadi et al., 2013, CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN., J. Biol. Chem.
Taylor et al., 2012, Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling., Blood
Gesbert et al., 1998, Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells., J. Biol. Chem.

QUIZARTINIB CBL

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type bone marrow cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
22990016

Sources:
JAX-CKB
ALDESLEUKIN CBL

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9461587

Sources:
NCI
FASUDIL CBL

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Indication/Tumor Type bone marrow cancer

Response Type predicted – sensitive

PMIDs:
26177294

Sources:
JAX-CKB
ERLOTINIB CBL

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Emerging

Approval Status Preclinical - Cell line xenograft

Response Type predicted – sensitive

PMIDs:
25348515

Sources:
JAX-CKB
DASATINIB CBL

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Variant Effect gain-of-function

Pathway activation

Clinical Status preclinical

PMIDs:
23696637

Sources:
DoCM
GEMCITABINE CBL

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Emerging

Approval Status Preclinical - Cell line xenograft

Response Type predicted – sensitive

PMIDs:
25348515

Sources:
JAX-CKB

Ensembl: ENSG00000110395
- Version: 101_38
Alternate Names:

CBL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

JAX-CKB: CBL

Version: 27-September-2017

Alternate Names:

867 CKB Entrez Id

CBL CKB Gene Synonym

C-CBL CKB Gene Synonym

Gene Info:

Publications:

Padron et al., 2015, An international data set for CMML validates prognostic scoring systems and demonstrates a need for novel prognostication strategies., Blood Cancer J

Itzykson et al., 2013, Prognostic score including gene mutations in chronic myelomonocytic leukemia., J. Clin. Oncol.

Makishima et al., 2009, Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies., J. Clin. Oncol.

CIViC: CBL
- Version: 14-September-2020
Alternate Names:

867 Entrez Gene ID

778 CIViC Gene ID

Gene Info:

Publications:

Tan YC et al., 2017, Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL., Sci Rep

DoCM: CBL

Version: 27-September-2017

Alternate Names:

Gene Info:

Publications:

Javadi et al., 2013, CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN., J. Biol. Chem.

NCI: CBL

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Gesbert et al., 1998, Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells., J. Biol. Chem.

Tanaka et al., 1996, c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption., Nature

Sargin et al., 2007, Flt3-dependent transformation by inactivating c-Cbl mutations in AML., Blood

HumanProteinAtlas: CBL
- Version: 19.3
Alternate Names:

ENSG00000110395 Ensembl Gene ID

c-Cbl Human Protein Atlas Gene Synonym

CBL2 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
Tempus: CBL
- Version: 11-November-2018
Alternate Names:

CBL Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: CBL
- Version: 01-February-2022
Alternate Names:

E3 ubiquitin-protein ligase CBL Gene Name

P22681 UniProt ID

Gene Info:

Gene Categories:

KINASE, ENZYME

Publications:
MskImpact: CBL
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: CBL
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: CBL
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: CBL
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Indication/Tumor Type	bone marrow cancer
Response Type	sensitive
Approval Status	Preclinical

Evidence Type	Actionable
Indication/Tumor Type	bone marrow cancer
Response Type	predicted – sensitive

Evidence Type	Emerging
Approval Status	Preclinical - Cell line xenograft
Response Type	predicted – sensitive

Variant Effect	gain-of-function
Pathway	activation
Clinical Status	preclinical

ENSG00000110395	Ensembl Gene ID
c-Cbl	Human Protein Atlas Gene Synonym
CBL2	Human Protein Atlas Gene Synonym

CBL Gene Record

CBL 867 Clinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

QUIZARTINIB CBL

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type bone marrow cancer Response Type sensitive Approval Status Preclinical

PMIDs: 22990016

Sources: JAX-CKB

ALDESLEUKIN CBL

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9461587

Sources: NCI

FASUDIL CBL

Interaction Types & Directionality: n/a

Interaction Info: Evidence Type Actionable Indication/Tumor Type bone marrow cancer Response Type predicted – sensitive

PMIDs: 26177294

Sources: JAX-CKB

ERLOTINIB CBL

Interaction Types & Directionality: n/a

Interaction Info: Evidence Type Emerging Approval Status Preclinical - Cell line xenograft Response Type predicted – sensitive

PMIDs: 25348515

Sources: JAX-CKB

DASATINIB CBL

Interaction Types & Directionality: n/a

Interaction Info: Variant Effect gain-of-function Pathway activation Clinical Status preclinical

PMIDs: 23696637

Sources: DoCM

GEMCITABINE CBL

Interaction Types & Directionality: n/a

Interaction Info: Evidence Type Emerging Approval Status Preclinical - Cell line xenograft Response Type predicted – sensitive

PMIDs: 25348515

Sources: JAX-CKB

Ensembl: ENSG00000110395

Alternate Names: CBL Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

JAX-CKB: CBL

Alternate Names: 867 CKB Entrez Id CBL CKB Gene Synonym C-CBL CKB Gene Synonym

Gene Info:

CIViC: CBL

Alternate Names: 867 Entrez Gene ID 778 CIViC Gene ID

Gene Info:

Publications: Tan YC et al., 2017, Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL., Sci Rep

DoCM: CBL

Alternate Names:

Gene Info:

Publications: Javadi et al., 2013, CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN., J. Biol. Chem.

NCI: CBL

Alternate Names:

Gene Info:

HumanProteinAtlas: CBL

Alternate Names: ENSG00000110395 Ensembl Gene ID c-Cbl Human Protein Atlas Gene Synonym CBL2 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

Tempus: CBL

Alternate Names: CBL Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Pharos: CBL

Alternate Names: E3 ubiquitin-protein ligase CBL Gene Name P22681 UniProt ID

Gene Info:

Gene Categories: KINASE, ENZYME

Publications:

MskImpact: CBL

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

FoundationOneGenes: CBL

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

CarisMolecularIntelligence: CBL

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type bone marrow cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
22990016

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
9461587

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Indication/Tumor Type bone marrow cancer

Response Type predicted – sensitive

PMIDs:
26177294

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Emerging

Approval Status Preclinical - Cell line xenograft

Response Type predicted – sensitive

PMIDs:
25348515

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Variant Effect gain-of-function

Pathway activation

Clinical Status preclinical

PMIDs:
23696637

Sources:
DoCM

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Emerging

Approval Status Preclinical - Cell line xenograft

Response Type predicted – sensitive

PMIDs:
25348515

Sources:
JAX-CKB

Alternate Names:

CBL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

867 CKB Entrez Id

CBL CKB Gene Synonym

C-CBL CKB Gene Synonym

Alternate Names:

867 Entrez Gene ID

778 CIViC Gene ID

Publications:

Tan YC et al., 2017, Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL., Sci Rep

Publications:

Javadi et al., 2013, CBL linker region and RING finger mutations lead to enhanced granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling via elevated levels of JAK2 and LYN., J. Biol. Chem.

Alternate Names:

ENSG00000110395 Ensembl Gene ID

c-Cbl Human Protein Atlas Gene Synonym

CBL2 Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

CBL Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

E3 ubiquitin-protein ligase CBL Gene Name

P22681 UniProt ID

Gene Categories:

KINASE, ENZYME

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE