DGIdb - CCR5 Gene Record

CCR5 1234 Druggable Genome

Alternate Names:

1234
C-C MOTIF CHEMOKINE RECEPTOR 5 (GENE/PSEUDOGENE)
CCR5
CC-CKR-5
CCCKR5
CCR-5
CD195
CKR-5
CKR5
CMKBR5
IDDM22
601373
1606
ENSG00000160791
OTTHUMG00000133481
PA26170
P51681
CHEMR13
C-C CHEMOKINE RECEPTOR TYPE 5
C-C CKR-5
HIV-1 FUSION CORECEPTOR
CCR5_HUMAN
ENSG00000188239
C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (HIV-1 FUSION CORECEPTOR) (CHEMR13) (CD195 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P51681]
CD_antigen=CD195
T09960
C-C motif chemokine receptor 5

Gene Info:

Human Readable Name	G PROTEIN COUPLED RECEPTOR
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Human Readable Name	DRUGGABLE GENOME
Transmembrane Helix Count	6
Target Main Class	Receptors
Interpro Type	Family
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Acc	IPR000276
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

CELL SURFACE
G PROTEIN COUPLED RECEPTOR
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Agrawal-Gamse et al., 2009, Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4., J. Virol.
Levy, 2009, HIV pathogenesis: 25 years of progress and persistent challenges., AIDS
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Napier et al., 2005, Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human., Biochem. Pharmacol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Trkola A et al., 2001, Potent, broad-spectrum inhibition of human immunodeficiency virus type 1 by the CCR5 monoclonal antibody PRO 140., J Virol
Miao M et al., 2020, Clinical significance of chemokine receptor antagonists., Expert Opin Drug Metab Toxicol
Akgün E et al., 2015, Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5)., J Med Chem
Tsibris AM et al., 2008, In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject., J Virol
Wilkin TJ et al., 2007, HIV type 1 chemokine coreceptor use among antiretroviral-experienced patients screened for a clinical trial of a CCR5 inhibitor: AIDS Clinical Trial Group A5211., Clin Infect Dis

MARAVIROC CCR5

Interaction Score: 33.73

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

Trial Name Selzentry

PMIDs:
19692476 19098484 11752352 16298345 17016423 17139284

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
VICRIVIROC CCR5

Interaction Score: 22.48

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Vicriviroc

Novel drug target Established target

PMIDs:
18495779 17243065

Sources:
TdgClinicalTrial TTD
LERONLIMAB CCR5

Interaction Score: 22.48

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

PMIDs:
11134270 31903790

Sources:
ChemblInteractions TTD
CHEMBL207004 CCR5

Interaction Score: 16.86

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
26451468

Sources:
DTC TTD
INCB-9471 CCR5

Interaction Score: 11.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CENICRIVIROC CCR5

Interaction Score: 8.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

Trial Name TBR-652, TAK-652

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
PF-232798 CCR5

Interaction Score: 5.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AZD5672 CCR5

Interaction Score: 5.62

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VICRIVIROC MALEATE CCR5

Interaction Score: 5.62

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PF-04634817 CCR5

Interaction Score: 2.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
APLAVIROC HYDROCHLORIDE CCR5

Interaction Score: 2.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000160791
- Version: 101_38
Alternate Names:

CCR5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000160791

Version: 26-July-2011

Alternate Names:

ENSG00000160791 Ensembl Gene Id

CCR5 Display Id

C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (HIV-1 FUSION CORECEPTOR) (CHEMR13) (CD195 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P51681] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P51681
- Version: 11-September-2012
Alternate Names:

CCR5 Uniprot Gene Name

1234 Entrez Gene Id

C-C CHEMOKINE RECEPTOR TYPE 5 Uniprot Protein Name

Gene Info:

Interpro Type Family

Interpro Short Name 7TM_GPCR_Rhodpsn

Human Readable Name DRUGGABLE GENOME

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000188239

Version: 26-July-2011

Alternate Names:

CCR5 Display Id

C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (HIV-1 FUSION CORECEPTOR) (CHEMR13) (CD195 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P51681] Description

ENSG00000188239 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: P51681
- Version: 01-August-2011
Alternate Names:

ENSG00000160791 Ensembl Gene Id

CCR5 Gene Symbol

CCR5_HUMAN Uniprot Id

Gene Info:

Target Subclass Rhodopsin

Target Subclass GPCR

Transmembrane Helix Count 6

Publications:
TdgClinicalTrial: P51681
- Version: January-2014
Alternate Names:

CCR5 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:

TTD: C-C chemokine receptor type 5

Version: 2020.06.01

Alternate Names:

CCR5 TTD Gene Abbreviation

T09960 TTD Target ID

Gene Info:

Publications:

Olson WC et al., 2009, CCR5 monoclonal antibodies for HIV-1 therapy., Curr Opin HIV AIDS

Tebas P et al., 2014, Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV., N Engl J Med

DTC: CCR5
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Akgün E et al., 2015, Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5)., J Med Chem
HingoraniCasas: ENSG00000160791
- Version: 31-May-2017
Alternate Names:

ENSG00000160791 Gene Symbol

CCR5 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CMKBR5
- Version: chembl_23
Alternate Names:

CMKBR5 GENE_SYMBOL

CCR5 GENE_SYMBOL

C-C chemokine receptor type 5 UNIPROT

Gene Info:

Publications:
PharmGKB: CCR5
- Version: 18-August-2020
Alternate Names:

PA26170 PharmGKB ID

Gene Info:

Publications:
GO: CCR5
- Version: 01-February-2022
Alternate Names:

CMKBR5 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
dGene: CCR5
- Version: 27-Jun-2013
Alternate Names:

1234 Gene ID

CC-CKR-5 dGene Synonym

CCCKR5 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Mechanism of Interaction	C-C chemokine receptor type 5 antagonist
Direct Interaction	yes
Trial Name	Selzentry

ENSG00000160791	Ensembl Gene Id
CCR5	Display Id
C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (HIV-1 FUSION CORECEPTOR) (CHEMR13) (CD195 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P51681]	Description

CCR5	Uniprot Gene Name
1234	Entrez Gene Id
C-C CHEMOKINE RECEPTOR TYPE 5	Uniprot Protein Name

CMKBR5	GENE_SYMBOL
CCR5	GENE_SYMBOL
C-C chemokine receptor type 5	UNIPROT

Trial Name	Vicriviroc
Novel drug target	Established target

antibody (inhibitory)
antagonist (inhibitory)

CCR5 Gene Record

CCR5 1234 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction C-C chemokine receptor type 5 antagonist Direct Interaction yes Trial Name Selzentry

PMIDs: 19692476 19098484 11752352 16298345 17016423 17139284

Sources: DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Vicriviroc Novel drug target Established target

PMIDs: 18495779 17243065

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: antibody (inhibitory) antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction C-C chemokine receptor type 5 antagonist

PMIDs: 11134270 31903790

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 26451468

Sources: DTC TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction C-C chemokine receptor type 5 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction C-C chemokine receptor type 5 antagonist Direct Interaction yes Trial Name TBR-652, TAK-652

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction C-C chemokine receptor type 5 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction C-C chemokine receptor type 5 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction C-C chemokine receptor type 5 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction C-C chemokine receptor type 5 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000160791

Alternate Names: CCR5 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000160791

Alternate Names: ENSG00000160791 Ensembl Gene Id CCR5 Display Id C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (HIV-1 FUSION CORECEPTOR) (CHEMR13) (CD195 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P51681] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P51681

Alternate Names: CCR5 Uniprot Gene Name 1234 Entrez Gene Id C-C CHEMOKINE RECEPTOR TYPE 5 Uniprot Protein Name

Gene Info: Interpro Type Family Interpro Short Name 7TM_GPCR_Rhodpsn Human Readable Name DRUGGABLE GENOME

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000188239

Alternate Names: CCR5 Display Id C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (HIV-1 FUSION CORECEPTOR) (CHEMR13) (CD195 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P51681] Description ENSG00000188239 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: P51681

Alternate Names: ENSG00000160791 Ensembl Gene Id CCR5 Gene Symbol CCR5_HUMAN Uniprot Id

Gene Info: Target Subclass Rhodopsin Target Subclass GPCR Transmembrane Helix Count 6

Publications:

TdgClinicalTrial: P51681

Alternate Names: CCR5 Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin

Publications:

TTD: C-C chemokine receptor type 5

Alternate Names: CCR5 TTD Gene Abbreviation T09960 TTD Target ID

Gene Info:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

Trial Name Selzentry

PMIDs:
19692476 19098484 11752352 16298345 17016423 17139284

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Vicriviroc

Novel drug target Established target

PMIDs:
18495779 17243065

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

PMIDs:
11134270 31903790

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
26451468

Sources:
DTC TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

Trial Name TBR-652, TAK-652

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

CCR5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000160791 Ensembl Gene Id

CCR5 Display Id

C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (HIV-1 FUSION CORECEPTOR) (CHEMR13) (CD195 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P51681] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CCR5 Uniprot Gene Name

1234 Entrez Gene Id

C-C CHEMOKINE RECEPTOR TYPE 5 Uniprot Protein Name

Gene Info:

Interpro Type Family

Interpro Short Name 7TM_GPCR_Rhodpsn

Human Readable Name DRUGGABLE GENOME

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

CCR5 Display Id

C-C CHEMOKINE RECEPTOR TYPE 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (HIV-1 FUSION CORECEPTOR) (CHEMR13) (CD195 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P51681] Description

ENSG00000188239 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000160791 Ensembl Gene Id

CCR5 Gene Symbol

CCR5_HUMAN Uniprot Id

Gene Info:

Target Subclass Rhodopsin

Target Subclass GPCR

Transmembrane Helix Count 6

Alternate Names:

CCR5 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

CCR5 TTD Gene Abbreviation

T09960 TTD Target ID

Publications:

Olson WC et al., 2009, CCR5 monoclonal antibodies for HIV-1 therapy., Curr Opin HIV AIDS

Tebas P et al., 2014, Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV., N Engl J Med

Publications:

Akgün E et al., 2015, Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5)., J Med Chem

Alternate Names:

ENSG00000160791 Gene Symbol

CCR5 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CMKBR5 GENE_SYMBOL

CCR5 GENE_SYMBOL

C-C chemokine receptor type 5 UNIPROT

Alternate Names:

PA26170 PharmGKB ID

Alternate Names:

CMKBR5 GO Gene Synonym

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

1234 Gene ID

CC-CKR-5 dGene Synonym

CCCKR5 dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR