DGIdb - CD19 Gene Record

CD19 930 Druggable Genome

Alternate Names:

930
CD19 MOLECULE
CD19
B4
CVID3
107265
1633
ENSG00000177455
OTTHUMG00000097049
B-lymphocyte surface antigen B4
CD_antigen=CD19
T-cell surface antigen Leu-12
B-lymphocyte antigen CD19
Differentiation antigen CD19
P15391
T56365

Gene Info:

Target Class	Miscellaneous
Target Subclass	Miscellaneous
Target Subclass	CD19
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Zugmaier et al., 2015, Clinical overview of anti-CD19 BiTE(®) and ex vivo data from anti-CD33 BiTE(®) as examples for retargeting T cells in hematologic malignancies., Mol. Immunol.
Gallagher S et al., 2016, Pharmacological profile of MEDI-551, a novel anti-CD19 antibody, in human CD19 transgenic mice., Int Immunopharmacol
Herbst R et al., 2010, B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody., J Pharmacol Exp Ther
Gallagher S et al., 2016, MEDI-551 Treatment Effectively Depletes B Cells and Reduces Serum Titers of Autoantibodies in Mice Transgenic for Sle1 and Human CD19., Arthritis Rheumatol

INEBILIZUMAB CD19

Interaction Score: 23.78

Interaction Types & Directionality:

antibody (inhibitory)

binder

Interaction Info:

Mechanism of Interaction B-lymphocyte antigen CD19 other

Direct Interaction yes

PMIDs:
27163209 20605905 26606525

Sources:
ChemblInteractions TTD
COLTUXIMAB RAVTANSINE CD19

Interaction Score: 14.27

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction B-lymphocyte antigen CD19 binding agent

Direct Interaction yes

Trial Name SAR3419

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
MDX-1342 CD19

Interaction Score: 9.51

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MDX-1342

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
TAPLITUMOMAB PAPTOX CD19

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction B-lymphocyte antigen CD19 binding agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ONCOLYSIN B CD19

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction B-lymphocyte antigen CD19 binding agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LISOCABTAGENE MARALEUCEL CD19

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DENINTUZUMAB MAFODOTIN CD19

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DUVORTUXIZUMAB CD19

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
VADACABTAGENE LERALEUCEL CD19

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TISAGENLECLEUCEL CD19

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BLINATUMOMAB CD19

Interaction Score: 2.72

Interaction Types & Directionality:

activator (activating)

antibody (inhibitory)

Interaction Info:

Mechanism of Interaction B-lymphocyte antigen CD19 cross-linking agent

Direct Interaction yes

Trial Name MT-103

PMIDs:
25883042

Sources:
TdgClinicalTrial ChemblInteractions TTD
AFM-11 CD19

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TISAGENLECLEUCEL CD19

Interaction Score: 2.38

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000177455
- Version: 101_38
Alternate Names:

CD19 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P15391
- Version: January-2014
Alternate Names:

CD19 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Miscellaneous

Target Subclass CD19

Publications:
ChemblInteractions: CD19
- Version: chembl_23
Alternate Names:

CD19 GENE_SYMBOL

B-lymphocyte antigen CD19 UNIPROT

B-lymphocyte surface antigen B4 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000177455
- Version: 31-May-2017
Alternate Names:

ENSG00000177455 Gene Symbol

CD19 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: CD19
- Version: 11-November-2018
Alternate Names:

CD19 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: B-lymphocyte surface antigen B4
- Version: 2020.06.01
Alternate Names:

CD19 TTD Gene Abbreviation

T56365 TTD Target ID

Gene Info:

Publications:
GO: CD19
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Mechanism of Interaction	B-lymphocyte antigen CD19 other
Direct Interaction	yes

Mechanism of Interaction	B-lymphocyte antigen CD19 binding agent
Direct Interaction	yes
Trial Name	SAR3419

Mechanism of Interaction	B-lymphocyte antigen CD19 cross-linking agent
Direct Interaction	yes
Trial Name	MT-103

CD19	GENE_SYMBOL
B-lymphocyte antigen CD19	UNIPROT
B-lymphocyte surface antigen B4	UNIPROT

antibody (inhibitory)
binder

Trial Name	MDX-1342
Novel drug target	Novel Target

activator (activating)
antibody (inhibitory)

CD19 Gene Record

CD19 930 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antibody (inhibitory) binder

Interaction Info: Mechanism of Interaction B-lymphocyte antigen CD19 other Direct Interaction yes

PMIDs: 27163209 20605905 26606525

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction B-lymphocyte antigen CD19 binding agent Direct Interaction yes Trial Name SAR3419

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name MDX-1342 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction B-lymphocyte antigen CD19 binding agent Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction B-lymphocyte antigen CD19 binding agent Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: activator (activating) antibody (inhibitory)

Interaction Info: Mechanism of Interaction B-lymphocyte antigen CD19 cross-linking agent Direct Interaction yes Trial Name MT-103

PMIDs: 25883042

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antibody (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Ensembl: ENSG00000177455

Alternate Names: CD19 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P15391

Alternate Names: CD19 Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Miscellaneous Target Subclass CD19

Publications:

ChemblInteractions: CD19

Alternate Names: CD19 GENE_SYMBOL B-lymphocyte antigen CD19 UNIPROT B-lymphocyte surface antigen B4 UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000177455

Alternate Names: ENSG00000177455 Gene Symbol CD19 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Tempus: CD19

Alternate Names: CD19 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

binder

Interaction Info:

Mechanism of Interaction B-lymphocyte antigen CD19 other

Direct Interaction yes

PMIDs:
27163209 20605905 26606525

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction B-lymphocyte antigen CD19 binding agent

Direct Interaction yes

Trial Name SAR3419

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MDX-1342

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction B-lymphocyte antigen CD19 binding agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction B-lymphocyte antigen CD19 binding agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

activator (activating)

antibody (inhibitory)

Interaction Info:

Mechanism of Interaction B-lymphocyte antigen CD19 cross-linking agent

Direct Interaction yes

Trial Name MT-103

PMIDs:
25883042

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antibody (inhibitory)

PMIDs:
None found

Sources:
TTD

Alternate Names:

CD19 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CD19 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Miscellaneous

Target Subclass CD19

Alternate Names:

CD19 GENE_SYMBOL

B-lymphocyte antigen CD19 UNIPROT

B-lymphocyte surface antigen B4 UNIPROT

Alternate Names:

ENSG00000177455 Gene Symbol

CD19 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CD19 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

CD19 TTD Gene Abbreviation

T56365 TTD Target ID

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE