DGIdb - CD38 Gene Record

CD38 952 Druggable Genome

Alternate Names:

952
CD38 MOLECULE
CD38
ADPRC 1
ADPRC1
107270
1667
ENSG00000004468
OTTHUMG00000048206
CD_antigen=CD38
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
2'-phospho-ADP-ribosyl cyclase
2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase
2'-phospho-cyclic-ADP-ribose transferase
ADP-ribosyl cyclase 1
T10
cADPr hydrolase 1
Cyclic ADP-ribose hydrolase 1
P28907
T10877

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.2.2
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

CELL SURFACE
DRUGGABLE GENOME

Publications:

Torti et al., 1998, Thrombin induces the association of cyclic ADP-ribose-synthesizing CD38 with the platelet cytoskeleton., FEBS Lett.
de Weers et al., 2011, Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors., J. Immunol.

DARATUMUMAB CD38

Interaction Score: 103.05

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Lymphocyte differentiation antigen CD38 inhibitor

Direct Interaction yes

Trial Name HuMax-CD38

PMIDs:
21187443

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions TTD
ISATUXIMAB CD38

Interaction Score: 20.61

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
THROMBIN CD38

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9654134

Sources:
NCI

Ensembl: ENSG00000004468
- Version: 101_38
Alternate Names:

CD38 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P28907
- Version: January-2014
Alternate Names:

CD38 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.2.2

Publications:
NCI: CD38
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Torti et al., 1998, Thrombin induces the association of cyclic ADP-ribose-synthesizing CD38 with the platelet cytoskeleton., FEBS Lett.
ChemblInteractions: CD38
- Version: chembl_23
Alternate Names:

CD38 GENE_SYMBOL

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 UNIPROT

2'-phospho-ADP-ribosyl cyclase UNIPROT

Gene Info:

Publications:
MyCancerGenome: CD38
- Version: 20-Jun-2017
Alternate Names:

952 Entrez Gene Id

CD38 MyCancerGenome Gene Symbol

CD38 MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000004468
- Version: 31-May-2017
Alternate Names:

ENSG00000004468 Gene Symbol

CD38 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Cyclic ADP-ribose hydrolase 1
- Version: 2020.06.01
Alternate Names:

CD38 TTD Gene Abbreviation

T10877 TTD Target ID

Gene Info:

Publications:
GO: CD38
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE

Publications:

Mechanism of Interaction	Lymphocyte differentiation antigen CD38 inhibitor
Direct Interaction	yes
Trial Name	HuMax-CD38

CD38	GENE_SYMBOL
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	UNIPROT
2'-phospho-ADP-ribosyl cyclase	UNIPROT

952	Entrez Gene Id
CD38	MyCancerGenome Gene Symbol
CD38	MyCancerGenome Reported Gene Name

antibody (inhibitory)
inhibitor (inhibitory)

antibody (inhibitory)
inhibitor (inhibitory)

CD38 Gene Record

CD38 952 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

DARATUMUMAB CD38

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Lymphocyte differentiation antigen CD38 inhibitor Direct Interaction yes Trial Name HuMax-CD38

PMIDs: 21187443

Sources: MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

ISATUXIMAB CD38

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

THROMBIN CD38

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9654134

Sources: NCI

Ensembl: ENSG00000004468

Alternate Names: CD38 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P28907

Alternate Names: CD38 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.2.2

Publications:

NCI: CD38

Alternate Names:

Gene Info:

Publications: Torti et al., 1998, Thrombin induces the association of cyclic ADP-ribose-synthesizing CD38 with the platelet cytoskeleton., FEBS Lett.

ChemblInteractions: CD38

Alternate Names: CD38 GENE_SYMBOL ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 UNIPROT 2'-phospho-ADP-ribosyl cyclase UNIPROT

Gene Info:

Publications:

MyCancerGenome: CD38

Alternate Names: 952 Entrez Gene Id CD38 MyCancerGenome Gene Symbol CD38 MyCancerGenome Reported Gene Name

Gene Info:

Publications:

HingoraniCasas: ENSG00000004468

Alternate Names: ENSG00000004468 Gene Symbol CD38 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Cyclic ADP-ribose hydrolase 1

Alternate Names: CD38 TTD Gene Abbreviation T10877 TTD Target ID

Gene Info:

Publications:

GO: CD38

Alternate Names:

Gene Info:

Gene Categories: CELL SURFACE

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Lymphocyte differentiation antigen CD38 inhibitor

Direct Interaction yes

Trial Name HuMax-CD38

PMIDs:
21187443

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
9654134

Sources:
NCI

Alternate Names:

CD38 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CD38 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.2.2

Publications:

Torti et al., 1998, Thrombin induces the association of cyclic ADP-ribose-synthesizing CD38 with the platelet cytoskeleton., FEBS Lett.

Alternate Names:

CD38 GENE_SYMBOL

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 UNIPROT

2'-phospho-ADP-ribosyl cyclase UNIPROT

Alternate Names:

952 Entrez Gene Id

CD38 MyCancerGenome Gene Symbol

CD38 MyCancerGenome Reported Gene Name

Alternate Names:

ENSG00000004468 Gene Symbol

CD38 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CD38 TTD Gene Abbreviation

T10877 TTD Target ID

Gene Categories:

CELL SURFACE