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CD3E 916 Druggable Genome
Alternate Names:
916 CD3E MOLECULE CD3E IMD18 T3E TCRE 186830 1674 ENSG00000198851 OTTHUMG00000166968 T-CELL SURFACE ANTIGEN T3/LEU-4 EPSILON CHAIN T-CELL SURFACE GLYCOPROTEIN CD3 EPSILON CHAIN P07766 CD3E_HUMAN CD_antigen=CD3e T-cell surface glycoprotein CD3 epsilon T87075 CD3epsilon Gene Info:
Transmembrane Helix Count 1 Target Main Class Receptors Target Subclass Other Target Subclass Ig Target Class Receptors Target Subclass Receptor Target Subclass T-cell receptor subunit Gene Biotype PROTEIN_CODING Gene Categories: Category Details
KINASE EXTERNAL SIDE OF PLASMA MEMBRANE DRUGGABLE GENOME Publications:
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Interaction Score: 10.82
Interaction Types & Directionality:
antibody (inhibitory) binder inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor Direct Interaction yes Trial Name - -
Interaction Score: 6.18
Interaction Types & Directionality:
n/a Interaction Info:
Direct Interaction yes Mechanism of Interaction T-cell surface glycoprotein CD3 epsilon chain other Trial Name teplizumab, MGA03 -
Interaction Score: 4.12
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Novel drug target Established target Trial Name Nuvion Mechanism of Interaction T-cell surface glycoprotein CD3 epsilon chain inhibitor -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name NI-0401 Novel drug target Established target Mechanism of Interaction T cell surface glycoprotein CD3 inhibitor -
Interaction Score: 4.12
Interaction Types & Directionality:
antibody (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction T-cell surface glycoprotein CD3 epsilon chain other Trial Name otelixizumab, TRX4, GSK2136525 -
Interaction Score: 4.12
Interaction Types & Directionality:
n/a Interaction Info:
Mechanism of Interaction T-cell surface glycoprotein CD3 epsilon chain other Direct Interaction yes -
Interaction Score: 3.09
Interaction Types & Directionality:
agonist (activating) antibody (inhibitory) Interaction Info:
Trial Name catumaxomab,Removab Novel drug target Established target -
Interaction Score: 1.77
Interaction Types & Directionality:
antibody (inhibitory) Interaction Info:
Mechanism of Interaction T cell surface glycoprotein CD3 cross-linking agent Direct Interaction yes Trial Name MT-103 -
Interaction Types & Directionality:
n/a Interaction Info:
Novel drug target Established target Trial Name MT110
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- Version: 101_38
Alternate Names:
CD3E Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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Alternate Names:
916 Entrez Gene Id CD3E_HUMAN Uniprot Id ENSG00000198851 Ensembl Gene Id Gene Info:
Transmembrane Helix Count 1 Target Main Class Receptors Target Subclass Other Publications:
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- Version: January-2014
Alternate Names:
CD3E Gene Symbol Gene Info:
Target Class Receptors Target Subclass Receptor Target Subclass T-cell receptor subunit Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000198851 Gene Symbol CD3E Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: chembl_23
Alternate Names:
T3E GENE_SYMBOL CD3E GENE_SYMBOL T-cell surface glycoprotein CD3 epsilon chain UNIPROT Gene Info:
Publications:
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Alternate Names:
T3E GO Gene Synonym Gene Info:
Gene Categories:
EXTERNAL SIDE OF PLASMA MEMBRANE Publications:
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- Version: 2020.06.01
Alternate Names:
CD3E TTD Gene Abbreviation T87075 TTD Target ID Gene Info:
Publications:
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Alternate Names:
T-cell surface glycoprotein CD3 epsilon chain Gene Name P07766 UniProt ID Gene Info:
Gene Categories:
KINASE Publications: