DGIdb - CDK1 Gene Record

CDK1 983 Druggable Genome

Alternate Names:

983
CYCLIN DEPENDENT KINASE 1
CDK1
CDC2
CDC28A
P34CDC2
116940
1722
ENSG00000170312
OTTHUMG00000018290
cyclin-dependent kinase 1
P06493
CDK1_HUMAN
CELL DIVISION CONTROL PROTEIN 2 HOMOLOG (EC 2.7.1.37) (P34 PROTEIN KINASE) (CYCLIN-DEPENDENT KINASE 1) (CDK1). [SOURCE:UNIPROT/SWISSPROT;ACC:P06493]
Cell division protein kinase 1
Cell division control protein 2 homolog
CDKN1
p34 protein kinase
CDK 1,2,5,9
CDK 1,2,4,5,6,7,9 (pan-CDK)
PA99
T49898

Gene Info:

Interpro Acc	IPR002290
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Human Readable Name	KINASE
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:2.7.11.22
Target Subclass	2.7.11.23
Initial Gene Query	CDC2
Counted Citations from 1950-2000	6569
CancerCommons Reported Gene Name	CDK1,2,5,9
CancerCommons Reported Gene Name	Pan CDK
Gene Biotype	PROTEIN_CODING

(13 More Sources)

Gene Categories: Category Details

DNA REPAIR
KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Wyatt PG et al., 2008, Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design., J Med Chem
MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
Asami Y et al., 2012, Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells., Bioorg Med Chem
Han CR et al., 2012, Induction of microtubule-damage, mitotic arrest, Bcl-2 phosphorylation, Bak activation, and mitochondria-dependent caspase cascade is involved in human Jurkat T-cell apoptosis by aruncin B from Aruncus dioicus var. kamtschaticus., Bioorg Med Chem Lett
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Iurisci I et al., 2006, Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor., Cancer Res
Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod

CHEMBL1082552 CDK1

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
ARUNCIN B CDK1

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22197393

Sources:
DTC
PROTUBOXEPIN A CDK1

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22595423

Sources:
DTC
RIVICICLIB CDK1

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD
AG-24322 CDK1

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD
DINACICLIB CDK1

Interaction Score: 0.72

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial
RG-547 CDK1

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CINNARIZINE CDK1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
RGB-286638 CDK1

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
MILCICLIB CDK1

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SELICICLIB CDK1

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

Direct Interaction yes

PMIDs:
17108108

Sources:
ChemblInteractions TTD
ALVOCIDIB CDK1

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name flavopiridol, alvocidib, HMR-1275

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

PMIDs:
11752352

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions
PATULIN CDK1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CHEMBL403183 CDK1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
WITHAFERIN A CDK1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24079846

Sources:
DTC
ZOTIRACICLIB CDK1

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ROTENONE CDK1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
AT-7519 CDK1

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs:
18656911

Sources:
DTC ChemblInteractions
CLOFIBRATE CDK1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
BMS-345541 CDK1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHA-793887 CDK1

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
SERTRALINE CDK1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CHIR-99021 CDK1

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
(RS)-ROSCOVITINE CDK1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENOFIBRATE CDK1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOTRIMAZOLE CDK1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
AZD-1080 CDK1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZD-5438 CDK1

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RONICICLIB CDK1

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALSTERPAULLONE CDK1

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11752352

Sources:
DTC
CHEMBL578061 CDK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LY-2090314 CDK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LAUROGUADINE CDK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RUCAPARIB CDK1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL541400 CDK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SNS-314 CDK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 CDK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KENPAULLONE CDK1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SOTRASTAURIN CDK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X CDK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL225519 CDK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 CDK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 CDK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 CDK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 CDK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 CDK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 CDK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB CDK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000170312
- Version: 101_38
Alternate Names:

CDK1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
CancerCommons: CDK1
- Version: 25-July-2013
Alternate Names:

983 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name CDK1,2,5,9

CancerCommons Reported Gene Name Pan CDK

Publications:
HopkinsGroom: P06493
- Version: 11-September-2012
Alternate Names:

P06493 Uniprot Accession

983 Entrez Gene Id

CDK1 Uniprot Gene Name

Gene Info:

Interpro Acc IPR002290

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P06493
- Version: January-2014
Alternate Names:

CDC2 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.22

Target Subclass 2.7.11.23

Publications:

RussLampel: ENSG00000170312

Version: 26-July-2011

Alternate Names:

CELL DIVISION CONTROL PROTEIN 2 HOMOLOG (EC 2.7.1.37) (P34 PROTEIN KINASE) (CYCLIN-DEPENDENT KINASE 1) (CDK1). [SOURCE:UNIPROT/SWISSPROT;ACC:P06493] Description

CDC2 Display Id

ENSG00000170312 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

BaderLabGenes: CDK1
- Version: February-2014
Alternate Names:

983 Entrez Gene ID

Gene Info:

Initial Gene Query CDC2

Counted Citations from 1950-2000 6569

Gene Categories:

KINASE

Publications:
PharmGKB: CDK1
- Version: 18-August-2020
Alternate Names:

PA99 PharmGKB ID

Gene Info:

Publications:

Pu X et al., 2014, Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer., Clin Pharmacol Ther

TTD: Cyclin-dependent kinase 1

Version: 2020.06.01

Alternate Names:

CDK1 TTD Gene Abbreviation

T49898 TTD Target ID

Gene Info:

Publications:

Ohnuma T et al., 2013, Phase 1 study of intravenous rigosertib (ON 01910.Na), a novel benzyl styryl sulfone structure producing G2/M arrest and apoptosis, in adult patients with advanced cancer., Am J Cancer Res

DTC: CDK1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Han CR et al., 2012, Induction of microtubule-damage, mitotic arrest, Bcl-2 phosphorylation, Bak activation, and mitochondria-dependent caspase cascade is involved in human Jurkat T-cell apoptosis by aruncin B from Aruncus dioicus var. kamtschaticus., Bioorg Med Chem Lett

MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

Asami Y et al., 2012, Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells., Bioorg Med Chem

HingoraniCasas: ENSG00000170312
- Version: 31-May-2017
Alternate Names:

ENSG00000170312 Gene Symbol

CDK1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: CDK1
- Version: 20-Jun-2017
Alternate Names:

983 Entrez Gene Id

CDK1 MyCancerGenome Gene Symbol

CDK 1,2,4,5,6,7,9 (pan-CDK) MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: CDC2
- Version: chembl_23
Alternate Names:

CDC28A GENE_SYMBOL

CDC2 GENE_SYMBOL

CDKN1 GENE_SYMBOL

Gene Info:

Publications:
GO: CDK1
- Version: 01-February-2022
Alternate Names:

CDC2 GO Gene Synonym

CDC28A GO Gene Synonym

CDKN1 GO Gene Synonym

Gene Info:

Gene Categories:

DNA REPAIR, SERINE THREONINE KINASE

Publications:
dGene: CDK1
- Version: 27-Jun-2013
Alternate Names:

983 Gene ID

CDC2 dGene Synonym

CDC28A dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
Pharos: CDK1
- Version: 01-February-2022
Alternate Names:

Cyclin-dependent kinase 1 Gene Name

P06493 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
MyCancerGenomeClinicalTrial: CDK1
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
ClearityFoundationClinicalTrial: CDK1
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Cyclin-dependent kinase 1 inhibitor

Reported Cancer Type	Melanoma
Mechanism of Interaction	Cyclin-dependent kinase 1 inhibitor
Direct Interaction	yes

Novel drug target	Novel Target
Trial Name	flavopiridol, alvocidib, HMR-1275
Mechanism of Interaction	Cyclin-dependent kinase 1 inhibitor

Direct Interaction	yes
Mechanism of Interaction	Cyclin-dependent kinase inhibitor

P06493	Uniprot Accession
983	Entrez Gene Id
CDK1	Uniprot Gene Name

CELL DIVISION CONTROL PROTEIN 2 HOMOLOG (EC 2.7.1.37) (P34 PROTEIN KINASE) (CYCLIN-DEPENDENT KINASE 1) (CDK1). [SOURCE:UNIPROT/SWISSPROT;ACC:P06493]	Description
CDC2	Display Id
ENSG00000170312	Ensembl Gene Id

983	Entrez Gene Id
CDK1	MyCancerGenome Gene Symbol
CDK 1,2,4,5,6,7,9 (pan-CDK)	MyCancerGenome Reported Gene Name

CDC2	GO Gene Synonym
CDC28A	GO Gene Synonym
CDKN1	GO Gene Synonym

CDK1 Gene Record

CDK1 983 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22197393

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22595423

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Melanoma Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor Direct Interaction yes

PMIDs: 17108108

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Novel Target Trial Name flavopiridol, alvocidib, HMR-1275 Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

PMIDs: 11752352

Sources: MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24079846

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs: 18656911

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22197393

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22595423

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

Direct Interaction yes

PMIDs:
17108108

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name flavopiridol, alvocidib, HMR-1275

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

PMIDs:
11752352

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24079846

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs:
18656911

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD