1019 |
CYCLIN DEPENDENT KINASE 4 |
CDK4 |
CMM3 |
PSK-J3 |
123829 |
1773 |
ENSG00000135446 |
OTTHUMG00000170382 |
CDK 4,6 |
CDK 1,2,4,5,6,7,9 (pan-CDK) |
P11802 |
cyclin-dependent kinase 4 |
CDK4_HUMAN |
CELL DIVISION PROTEIN KINASE 4 |
CELL DIVISION PROTEIN KINASE 4 (EC 2.7.1.37) (CYCLIN-DEPENDENT KINASE 4) (PSK-J3). [SOURCE:UNIPROT/SWISSPROT;ACC:P11802] |
13 |
PA102 |
T85799 |
Interpro Type | Domain |
Uniprot Status | Swiss-Prot |
Interpro Name | Serine/threonine- / dual-specificity protein kinase, catalytic domain |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR002290 |
Human Readable Name | KINASE |
Interpro Short Name | Ser/Thr_dual-sp_kinase_dom |
Uniprot Evidence | 1: Evidence at protein level |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.22 |
CancerCommons Reported Gene Name | CDK4/6 |
CancerCommons Reported Gene Name | Pan CDK |
Initial Gene Query | CDK4 |
Counted Citations from 1950-2000 | 3030 |
Gene Biotype | PROTEIN_CODING |
TRANSCRIPTION FACTOR COMPLEX |
TUMOR SUPPRESSOR |
KINASE |
SERINE THREONINE KINASE |
DRUG RESISTANCE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
TRANSCRIPTION FACTOR |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase 4 inhibitor |
Direct Interaction | yes |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Trial Name | LEE011 |
Novel drug target | Novel Target |
Mechanism of Interaction | Cyclin-dependent kinase 4 inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Reported Cancer Type | Melanoma |
Mechanism of Interaction | Cyclin-dependent kinase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Reported Cancer Type | Melanoma |
Mechanism of Interaction | CDK4/cyclin D1 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclin-dependent kinase 4 inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase 4 inhibitor |
Direct Interaction | yes |
Novel drug target | Novel Target |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclin-dependent kinase inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclin-dependent kinase inhibitor |
CDK4 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
CDK4 | Uniprot Gene Name |
1019 | Entrez Gene Id |
ENSG00000135446 | Ensembl Gene Id |
Interpro Type | Domain |
Uniprot Status | Swiss-Prot |
Interpro Name | Serine/threonine- / dual-specificity protein kinase, catalytic domain |
KINASE, DRUGGABLE GENOME |
CELL DIVISION PROTEIN KINASE 4 (EC 2.7.1.37) (CYCLIN-DEPENDENT KINASE 4) (PSK-J3). [SOURCE:UNIPROT/SWISSPROT;ACC:P11802] | Description |
ENSG00000135446 | Ensembl Gene Id |
CDK4 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
1019 | Entrez Gene ID |
CancerCommons Reported Gene Name | CDK4/6 |
CancerCommons Reported Gene Name | Pan CDK |
1019 | Entrez Gene ID |
Initial Gene Query | CDK4 |
Counted Citations from 1950-2000 | 3030 |
KINASE |
CDK4 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.22 |
PA102 | PharmGKB ID |
1019 | Entrez Gene ID |
13 | CIViC Gene ID |
DRUG RESISTANCE |
ENSG00000135446 | Gene Symbol |
CDK4 | Ensembl Id |
DRUGGABLE GENOME |
1019 | Entrez Gene Id |
CDK4 | MyCancerGenome Gene Symbol |
CDK 1,2,4,5,6,7,9 (pan-CDK) | MyCancerGenome Reported Gene Name |
CDK4 | Gene Symbol |
CDK4 | GENE_SYMBOL |
Cyclin-dependent kinase 4 | UNIPROT |
Cell division protein kinase 4 | UNIPROT |
1019 | OncoKB Entrez Id |
PSK-J3 | OncoKB Gene Synonym |
CMM3 | OncoKB Gene Synonym |
CDK4 | Gene Symbol |
CLINICALLY ACTIONABLE |
1019 | Gene ID |
CMM3 | dGene Synonym |
PSK-J3 | dGene Synonym |
KINASE, SERINE THREONINE KINASE |
CDK4 | TTD Gene Abbreviation |
T85799 | TTD Target ID |
Cyclin-dependent kinase 4 | Gene Name |
P11802 | UniProt ID |
KINASE, TRANSCRIPTION FACTOR |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR |
CLINICALLY ACTIONABLE |