CDK5 Gene Record

  • CDK5 1020 Druggable Genome

    Alternate Names:

    1020
    CYCLIN DEPENDENT KINASE 5
    CDK5
    LIS7
    PSSALRE
    123831
    1774
    ENSG00000164885
    OTTHUMG00000158414
    Q00535
    CDKN5
    Cyclin-dependent-like kinase 5
    TPKII catalytic subunit
    Tau protein kinase II catalytic subunit
    Serine/threonine-protein kinase PSSALRE
    Cell division protein kinase 5
    cyclin-dependent kinase 5
    CDK5_HUMAN
    CELL DIVISION PROTEIN KINASE 5 (EC 2.7.1.37) (TAU PROTEIN KINASE II CATALYTIC SUBUNIT) (TPKII CATALYTIC SUBUNIT) (SERINE/THREONINE-PROTEIN KINASE PSSALRE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q00535]
    CDK 1,2,5,9
    CDK 1,2,4,5,6,7,9 (pan-CDK)
    T20973

    Gene Info:

    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Interpro Acc IPR002290
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name KINASE
    Uniprot Status Swiss-Prot
    Target Class Enzymes
    Target Subclass EC:2.7.11.22
    CancerCommons Reported Gene Name CDK1,2,5,9
    Gene Biotype PROTEIN_CODING
    (11 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

  • OLOMOUCINE   CDK5

    Interaction Score: 0.74

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11752352


    Sources:
    DTC

  • DINACICLIB   CDK5

    Interaction Score: 0.65

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 5 inhibitor
    Direct Interaction yes
    Reported Cancer Type Melanoma

    PMIDs:
    None found


    Sources:
    MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions CancerCommons

  • CHEMBL1276446   CDK5

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL261692   CDK5

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1406948   CDK5

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL300389   CDK5

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALVOCIDIB   CDK5

    Interaction Score: 0.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name flavopiridol, alvocidib, HMR-1275
    Novel drug target Novel Target

    PMIDs:
    11752352


    Sources:
    MyCancerGenome TdgClinicalTrial

  • CHEMBL259850   CDK5

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RGB-286638   CDK5

    Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase 5 inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SELICICLIB   CDK5

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase 5 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BMS-387032   CDK5

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • (RS)-ROSCOVITINE   CDK5

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZD-1080   CDK5

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL322970   CDK5

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZD-5438   CDK5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RONICICLIB   CDK5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PHA-793887   CDK5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclin-dependent kinase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AT-7519   CDK5

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclin-dependent kinase inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • KENPAULLONE   CDK5

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC TTD

  • ALSTERPAULLONE   CDK5

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11752352


    Sources:
    DTC

  • HAEMATOXYLIN   CDK5

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LY-2090314   CDK5

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL406845   CDK5

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ADAVOSERTIB   CDK5

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FASUDIL   CDK5

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PURPUROGALLIN   CDK5

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL541400   CDK5

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1997335   CDK5

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GO-6976   CDK5

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL379975   CDK5

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PALBOCICLIB   CDK5

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • JNJ-7706621   CDK5

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SOTRASTAURIN   CDK5

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW441756X   CDK5

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL225519   CDK5

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • R-406   CDK5

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RG-1530   CDK5

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SP-600125   CDK5

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYC-116   CDK5

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAE-684   CDK5

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   CDK5

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CENISERTIB   CDK5

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000164885

    • Version: 101_38

    Alternate Names:
    CDK5 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: Q00535

    • Version: 11-September-2012

    Alternate Names:
    CDK5_HUMAN Uniprot Id
    ENSG00000164885 Ensembl Gene Id
    1020 Entrez Gene Id

    Gene Info:
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • CancerCommons: CDK5

    • Version: 25-July-2013

    Alternate Names:
    1020 Entrez Gene ID

    Gene Info:
    CancerCommons Reported Gene Name CDK1,2,5,9

    Publications:

  • TdgClinicalTrial: Q00535

    • Version: January-2014

    Alternate Names:
    CDK5 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.22

    Publications:

  • RussLampel: ENSG00000164885

    • Version: 26-July-2011

    Alternate Names:
    CELL DIVISION PROTEIN KINASE 5 (EC 2.7.1.37) (TAU PROTEIN KINASE II CATALYTIC SUBUNIT) (TPKII CATALYTIC SUBUNIT) (SERINE/THREONINE-PROTEIN KINASE PSSALRE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q00535] Description
    ENSG00000164885 Ensembl Gene Id
    CDK5 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HingoraniCasas: ENSG00000164885

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000164885 Gene Symbol
    CDK5 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: CDKN5

    • Version: chembl_23

    Alternate Names:
    CDKN5 GENE_SYMBOL
    CDK5 GENE_SYMBOL
    Cyclin-dependent-like kinase 5 UNIPROT

    Gene Info:

    Publications:

  • MyCancerGenome: CDK5

    • Version: 20-Jun-2017

    Alternate Names:
    1020 Entrez Gene Id
    CDK5 MyCancerGenome Gene Symbol
    CDK 1,2,4,5,6,7,9 (pan-CDK) MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • HumanProteinAtlas: CDK5

    • Version: 19.3

    Alternate Names:
    ENSG00000164885 Ensembl Gene ID
    PSSALRE Human Protein Atlas Gene Synonym
    Cyclin dependent kinase 5 Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: CDK5

    • Version: 01-February-2022

    Alternate Names:
    CDKN5 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR, KINASE, SERINE THREONINE KINASE

    Publications:

  • dGene: CDK5

    • Version: 27-Jun-2013

    Alternate Names:
    1020 Gene ID
    PSSALRE dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: Cyclin-dependent kinase 5

    • Version: 2020.06.01

    Alternate Names:
    CDK5 TTD Gene Abbreviation
    T20973 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: CDK5

    • Version: 01-February-2022

    Alternate Names:
    Cyclin-dependent-like kinase 5 Gene Name
    Q00535 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • ClearityFoundationClinicalTrial: CDK5

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

  • DTC: CDK5

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications: