DGIdb - CDK6 Gene Record

CDK6 1021 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

1021
CYCLIN DEPENDENT KINASE 6
CDK6
MCPH12
PLSTIRE
603368
1777
ENSG00000105810
OTTHUMG00000131697
CDK 4,6
CDK 1,2,4,5,6,7,9 (pan-CDK)
CELL DIVISION PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE-PROTEIN KINASE PLSTIRE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q00534]
CDKN6
Cyclin-dependent kinase 6
Cell division protein kinase 6
Serine/threonine-protein kinase PLSTIRE
Q00534
CDK6_HUMAN
12
T89361

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Enzymes
Target Subclass	EC:2.7.11.22
Interpro Acc	IPR002290
Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	KINASE
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
CancerCommons Reported Gene Name	CDK4/6
Gene Biotype	PROTEIN_CODING

(18 More Sources)

Gene Categories: Category Details

TUMOR SUPPRESSOR
KINASE
SERINE THREONINE KINASE
DRUG RESISTANCE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Fry et al., 2004, Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts., Mol. Cancer Ther.
Rocca A et al., 2017, Progress with palbociclib in breast cancer: latest evidence and clinical considerations., Ther Adv Med Oncol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Rader et al., 2013, Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma., Clin. Cancer Res.
Bortolozzi R et al., 2018, Ribociclib, a Cdk4/Cdk6 kinase inhibitor, enhances glucocorticoid sensitivity in B-acute lymphoblastic leukemia (B-All)., Biochem Pharmacol
Alves et al., 2016, High CDK6 Protects Cells from Fulvestrant-Mediated Apoptosis and is a Predictor of Resistance to Fulvestrant in Estrogen Receptor-Positive Metastatic Breast Cancer., Clin. Cancer Res.
Gelbert et al., 2014, Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine., Invest New Drugs

G1T28-1 CDK6

Interaction Score: 3.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
RIBOCICLIB SUCCINATE CDK6

Interaction Score: 1.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
LEROCICLIB CDK6

Interaction Score: 1.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
RIBOCICLIB CDK6

Interaction Score: 1.69

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

Direct Interaction yes

Trial Name LEE011

PMIDs:
24045179 29408328

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions CIViC TTD
TRILACICLIB CDK6

Interaction Score: 1.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
ABEMACICLIB CDK6

Interaction Score: 1.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

Direct Interaction yes

PMIDs:
24919854

Sources:
ChemblInteractions CancerCommons TTD
ALVOCIDIB CDK6

Interaction Score: 1.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

Direct Interaction yes

Trial Name flavopiridol, alvocidib, HMR-1275

PMIDs:
11752352

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions
APREMILAST CDK6

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
FULVESTRANT CDK6

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27252418

Sources:
CIViC
PALBOCICLIB CDK6

Interaction Score: 0.5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Mechanism of Interaction CDK6/cyclin D1 inhibitor

Direct Interaction yes

PMIDs:
15542782 28203301

Sources:
MyCancerGenome ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial
RONICICLIB CDK6

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
UCN-01 CDK6

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AZD-5438 CDK6

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
AT-7519 CDK6

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
PHA-793887 CDK6

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DEXAMETHASONE CDK6

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29408328

Sources:
CIViC

Ensembl: ENSG00000105810
- Version: 101_38
Alternate Names:

CDK6 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q00534
- Version: 11-September-2012
Alternate Names:

CDK6 Uniprot Gene Name

Q00534 Uniprot Accession

ENSG00000105810 Ensembl Gene Id

Gene Info:

Interpro Acc IPR002290

Uniprot Status Swiss-Prot

Interpro Type Domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q00534
- Version: January-2014
Alternate Names:

CDK6 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.22

Publications:

RussLampel: ENSG00000105810

Version: 26-July-2011

Alternate Names:

CDK6 Display Id

ENSG00000105810 Ensembl Gene Id

CELL DIVISION PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE-PROTEIN KINASE PLSTIRE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q00534] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

CancerCommons: CDK6
- Version: 25-July-2013
Alternate Names:

1021 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name CDK4/6

Publications:

CIViC: CDK6

Version: 14-September-2020

Alternate Names:

1021 Entrez Gene ID

12 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Bortolozzi R et al., 2018, Ribociclib, a Cdk4/Cdk6 kinase inhibitor, enhances glucocorticoid sensitivity in B-acute lymphoblastic leukemia (B-All)., Biochem Pharmacol

Alves et al., 2016, High CDK6 Protects Cells from Fulvestrant-Mediated Apoptosis and is a Predictor of Resistance to Fulvestrant in Estrogen Receptor-Positive Metastatic Breast Cancer., Clin. Cancer Res.

TALC: CDK6
- Version: 12-May-2016
Alternate Names:

CDK6 Gene Symbol

Gene Info:

Publications:
MyCancerGenome: CDK6
- Version: 20-Jun-2017
Alternate Names:

1021 Entrez Gene Id

CDK6 MyCancerGenome Gene Symbol

CDK 1,2,4,5,6,7,9 (pan-CDK) MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: CDKN6
- Version: chembl_23
Alternate Names:

CDKN6 GENE_SYMBOL

CDK6 GENE_SYMBOL

Cyclin-dependent kinase 6 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000105810
- Version: 31-May-2017
Alternate Names:

ENSG00000105810 Gene Symbol

CDK6 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: CDK6
- Version: 01-February-2022
Alternate Names:

CDKN6 GO Gene Synonym

Gene Info:

Gene Categories:

TUMOR SUPPRESSOR

Publications:
Tempus: CDK6
- Version: 11-November-2018
Alternate Names:

CDK6 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: CDK6
- Version: 27-Jun-2013
Alternate Names:

1021 Gene ID

PLSTIRE dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Cyclin-dependent kinase 6
- Version: 2020.06.01
Alternate Names:

CDK6 TTD Gene Abbreviation

T89361 TTD Target ID

Gene Info:

Publications:
Pharos: CDK6
- Version: 01-February-2022
Alternate Names:

Cyclin-dependent kinase 6 Gene Name

Q00534 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
ClearityFoundationClinicalTrial: CDK6
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
MyCancerGenomeClinicalTrial: CDK6
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
MskImpact: CDK6
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
DTC: CDK6
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: CDK6
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: CDK6
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: CDK6
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Cyclin-dependent kinase 6 inhibitor
Direct Interaction	yes

Reported Cancer Type	Melanoma
Mechanism of Interaction	Cyclin-dependent kinase 6 inhibitor
Direct Interaction	yes

Mechanism of Interaction	Cyclin-dependent kinase inhibitor
Direct Interaction	yes

CDK6	Uniprot Gene Name
Q00534	Uniprot Accession
ENSG00000105810	Ensembl Gene Id

CDK6	Display Id
ENSG00000105810	Ensembl Gene Id
CELL DIVISION PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE-PROTEIN KINASE PLSTIRE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q00534]	Description

1021	Entrez Gene Id
CDK6	MyCancerGenome Gene Symbol
CDK 1,2,4,5,6,7,9 (pan-CDK)	MyCancerGenome Reported Gene Name

CDKN6	GENE_SYMBOL
CDK6	GENE_SYMBOL
Cyclin-dependent kinase 6	UNIPROT

antagonist (inhibitory)
inhibitor (inhibitory)

CDK6 Gene Record

CDK6 1021 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor Direct Interaction yes Trial Name LEE011

PMIDs: 24045179 29408328

Sources: MyCancerGenome TdgClinicalTrial ChemblInteractions CIViC TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Melanoma Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor Direct Interaction yes

PMIDs: 24919854

Sources: ChemblInteractions CancerCommons TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor Direct Interaction yes Trial Name flavopiridol, alvocidib, HMR-1275

PMIDs: 11752352

Sources: DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27252418

Sources: CIViC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Melanoma Mechanism of Interaction CDK6/cyclin D1 inhibitor Direct Interaction yes

PMIDs: 15542782 28203301

Sources: MyCancerGenome ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29408328

Sources: CIViC

Ensembl: ENSG00000105810

Alternate Names: CDK6 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: Q00534

Alternate Names: CDK6 Uniprot Gene Name Q00534 Uniprot Accession ENSG00000105810 Ensembl Gene Id

Gene Info: Interpro Acc IPR002290 Uniprot Status Swiss-Prot Interpro Type Domain

Gene Categories: KINASE, DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q00534

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

Direct Interaction yes

Trial Name LEE011

PMIDs:
24045179 29408328

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions CIViC TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

Direct Interaction yes

PMIDs:
24919854

Sources:
ChemblInteractions CancerCommons TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

Direct Interaction yes

Trial Name flavopiridol, alvocidib, HMR-1275

PMIDs:
11752352

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
27252418

Sources:
CIViC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Mechanism of Interaction CDK6/cyclin D1 inhibitor

Direct Interaction yes

PMIDs:
15542782 28203301

Sources:
MyCancerGenome ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclin-dependent kinase 6 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclin-dependent kinase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
29408328

Sources:
CIViC

Alternate Names:

CDK6 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CDK6 Uniprot Gene Name

Q00534 Uniprot Accession

ENSG00000105810 Ensembl Gene Id

Gene Info:

Interpro Acc IPR002290

Uniprot Status Swiss-Prot

Interpro Type Domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Alternate Names:

CDK6 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.22

Alternate Names:

CDK6 Display Id

ENSG00000105810 Ensembl Gene Id

CELL DIVISION PROTEIN KINASE 6 (EC 2.7.1.37) (SERINE/THREONINE-PROTEIN KINASE PLSTIRE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q00534] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

1021 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name CDK4/6

Alternate Names:

1021 Entrez Gene ID

12 CIViC Gene ID

Gene Categories:

DRUG RESISTANCE

Alternate Names:

CDK6 Gene Symbol

Alternate Names:

1021 Entrez Gene Id

CDK6 MyCancerGenome Gene Symbol

CDK 1,2,4,5,6,7,9 (pan-CDK) MyCancerGenome Reported Gene Name

Alternate Names:

CDKN6 GENE_SYMBOL

CDK6 GENE_SYMBOL

Cyclin-dependent kinase 6 UNIPROT

Alternate Names:

ENSG00000105810 Gene Symbol

CDK6 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CDKN6 GO Gene Synonym

Gene Categories:

TUMOR SUPPRESSOR