1024 |
CYCLIN DEPENDENT KINASE 8 |
CDK8 |
K35 |
603184 |
1779 |
ENSG00000132964 |
OTTHUMG00000016617 |
CELL DIVISION PROTEIN KINASE 8 (EC 2.7.1.37) (PROTEIN KINASE K35). [SOURCE:UNIPROT/SWISSPROT;ACC:P49336] |
Cell division protein kinase 8 |
Mediator complex subunit CDK8 |
Mediator of RNA polymerase II transcription subunit CDK8 |
Cyclin-dependent kinase 8 |
Protein kinase K35 |
P49336 |
CDK8_HUMAN |
T10822 |
IDDHBA |
Human Readable Name | DRUGGABLE GENOME |
Interpro Type | Domain |
Human Readable Name | KINASE |
Uniprot Evidence | 1: Evidence at protein level |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR002290 |
Interpro Name | Serine/threonine- / dual-specificity protein kinase, catalytic domain |
Interpro Short Name | Ser/Thr_dual-sp_kinase_dom |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.22 |
Target Subclass | 2.7.11.23 |
Gene Biotype | PROTEIN_CODING |
TUMOR SUPPRESSOR |
KINASE |
SERINE THREONINE KINASE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
TRANSCRIPTION FACTOR |
n/a |
Trial Name | flavopiridol, alvocidib, HMR-1275 |
Novel drug target | Novel Target |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Cyclin-dependent kinase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Cyclin-dependent kinase inhibitor |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
CDK8 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
CELL DIVISION PROTEIN KINASE 8 (EC 2.7.1.37) (PROTEIN KINASE K35). [SOURCE:UNIPROT/SWISSPROT;ACC:P49336] | Description |
ENSG00000132964 | Ensembl Gene Id |
CDK8 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
CDK8 | Uniprot Gene Name |
1024 | Entrez Gene Id |
ENSG00000132964 | Ensembl Gene Id |
Interpro Type | Domain |
Human Readable Name | KINASE |
Uniprot Evidence | 1: Evidence at protein level |
KINASE, DRUGGABLE GENOME |
CDK8 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.11.22 |
Target Subclass | 2.7.11.23 |
ENSG00000132964 | Gene Symbol |
CDK8 | Ensembl Id |
DRUGGABLE GENOME |
CDK8 | GENE_SYMBOL |
Cyclin-dependent kinase 8 | UNIPROT |
Cell division protein kinase 8 | UNIPROT |
CDK8 | Gene Symbol |
CLINICALLY ACTIONABLE |
1024 | Gene ID |
K35 | dGene Synonym |
KINASE, SERINE THREONINE KINASE |
CDK8 | TTD Gene Abbreviation |
T10822 | TTD Target ID |
Cyclin-dependent kinase 8 | Gene Name |
P49336 | UniProt ID |
KINASE, TRANSCRIPTION FACTOR |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
TUMOR SUPPRESSOR |