CHEK2 Gene Record

  • CHEK2 11200 Druggable GenomeClinically Actionable

    Alternate Names:

    11200
    CHECKPOINT KINASE 2
    CHEK2
    CDS1
    CHK2
    HuCds1
    LFS2
    PP1425
    RAD53
    hCds1
    604373
    16627
    ENSG00000183765
    OTTHUMG00000151023
    O96017
    CHK2_HUMAN
    SERINE/THREONINE-PROTEIN KINASE CHK2 (EC 2.7.1.37) (CDS1). [SOURCE:UNIPROT/SWISSPROT;ACC:O96017]
    SERINE/THREONINE-PROTEIN KINASE CHK2
    Cds1 homolog
    CHK2 checkpoint homolog
    bA444G7

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002290
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name KINASE
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Type Domain
    Target Class Enzymes
    Target Subclass EC:2.7.11.1
    Gene Biotype PROTEIN_CODING
    (11 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

  • WITHAFERIN A   CHEK2

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24079846


    Sources:
    DTC

  • DIMETHYLADENINE   CHEK2

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZD-1152-HQPA   CHEK2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL578061   CHEK2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MLN-8054   CHEK2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FASUDIL   CHEK2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SNS-314   CHEK2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GO-6976   CHEK2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CEDIRANIB   CHEK2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KENPAULLONE   CHEK2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALSTERPAULLONE   CHEK2

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW441756X   CHEK2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GEFITINIB   CHEK2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RG-1530   CHEK2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOVITINIB   CHEK2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SP-600125   CHEK2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYC-116   CHEK2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAE-684   CHEK2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ILORASERTIB   CHEK2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   CHEK2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CENISERTIB   CHEK2

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000183765

    • Version: 101_38

    Alternate Names:
    CHEK2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000183765

    • Version: 26-July-2011

    Alternate Names:
    SERINE/THREONINE-PROTEIN KINASE CHK2 (EC 2.7.1.37) (CDS1). [SOURCE:UNIPROT/SWISSPROT;ACC:O96017] Description
    CHEK2 Display Id
    ENSG00000183765 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: O96017

    • Version: January-2014

    Alternate Names:
    CHEK2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.1

    Publications:

  • HopkinsGroom: O96017

    • Version: 11-September-2012

    Alternate Names:
    CHK2_HUMAN Uniprot Id
    11200 Entrez Gene Id
    O96017 Uniprot Accession

    Gene Info:
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • DTC: CHEK2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod

  • HingoraniCasas: ENSG00000183765

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000183765 Gene Symbol
    CHEK2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: CHEK2

    • Version: 19.3

    Alternate Names:
    ENSG00000183765 Ensembl Gene ID
    bA444G7 Human Protein Atlas Gene Synonym
    CDS1 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: CHEK2

    • Version: 01-February-2022

    Alternate Names:
    CDS1 GO Gene Synonym
    CHK2 GO Gene Synonym
    RAD53 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • Tempus: CHEK2

    • Version: 11-November-2018

    Alternate Names:
    CHEK2 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: CHEK2

    • Version: 27-Jun-2013

    Alternate Names:
    11200 Gene ID
    CDS1 dGene Synonym
    CHK2 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • Pharos: CHEK2

    • Version: 01-February-2022

    Alternate Names:
    Serine/threonine-protein kinase Chk2 Gene Name
    O96017 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • MskImpact: CHEK2

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: CHEK2

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: CHEK2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: CHEK2

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: