1139 |
CHOLINERGIC RECEPTOR NICOTINIC ALPHA 7 SUBUNIT |
CHRNA7 |
CHRNA7-2 |
NACHRA7 |
118511 |
1960 |
ENSG00000175344 |
OTTHUMG00000129285 |
Neuronal acetylcholine receptor subunit alpha-7 |
P36544 |
ACHA7_HUMAN |
1139; 89832 |
NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-7 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P36544] |
PA114 |
Neuronal acetylcholine receptor alpha-7 |
T34429 |
Interpro Acc | IPR006202 |
Human Readable Name | ION CHANNEL |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR006201 |
Uniprot Status | Swiss-Prot |
Interpro Name | Neurotransmitter-gated ion-channel |
Interpro Type | Domain |
Interpro Type | Family |
Interpro Short Name | Neur_chan_lig-bd |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Interpro Short Name | Neur_channel |
Uniprot Evidence | 1: Evidence at protein level |
Target Class | Receptors |
Target Subclass | TC:1.A.9.1.1 |
Target Subclass | Channels |
Target Subclass | cys-loop |
Target Subclass | Ligand_gated_ion_channels |
Target Main Class | Receptors |
Transmembrane Helix Count | 4 |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
n/a |
Trial Name | GTS-21 |
Novel drug target | Established target |
partial agonist (activating) |
agonist (activating) |
Novel drug target | Established target |
Trial Name | EVP-6124 |
Direct Interaction | yes |
partial agonist (activating) |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist |
Direct Interaction | yes |
agonist (activating) |
Novel drug target | Established target |
Trial Name | TC-6987Êby Targacept forÊasthmaÊandÊtype II diabetes |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit agonist |
agonist (activating) |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit agonist |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit positive allosteric modulator |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit agonist |
Direct Interaction | yes |
partial agonist (activating) |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist |
partial agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist |
agonist (activating) |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit agonist |
Trial Name | TC-5619 |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
Trial Name | varenicline, CP-526 |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
partial agonist (activating) |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
modulator |
Mechanism of Interaction | Neuronal acetylcholine receptor protein alpha-7 subunit modulator |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
CHRNA7 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000175344 | Ensembl Gene Id |
P36544 | Uniprot Accession |
1139 | Entrez Gene Id |
Interpro Acc | IPR006202 |
Human Readable Name | ION CHANNEL |
Human Readable Name | DRUGGABLE GENOME |
ION CHANNEL, DRUGGABLE GENOME |
CHRNA7 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9.1.1 |
NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-7 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P36544] | Description |
CHRNA7 | Display Id |
ENSG00000175344 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
1139; 89832 | Entrez Gene Id |
ACHA7_HUMAN | Uniprot Id |
P36544 | Uniprot Accession |
Target Subclass | Channels |
Target Subclass | cys-loop |
Target Subclass | Ligand_gated_ion_channels |
PA114 | PharmGKB ID |
NACHRA7 | GENE_SYMBOL |
CHRNA7 | GENE_SYMBOL |
Neuronal acetylcholine receptor subunit alpha-7 | UNIPROT |
ENSG00000175344 | Gene Symbol |
CHRNA7 | Ensembl Id |
DRUGGABLE GENOME |
NACHRA7 | GO Gene Synonym |
ION CHANNEL |
CHRNA7 | TTD Gene Abbreviation |
T34429 | TTD Target ID |
Neuronal acetylcholine receptor subunit alpha-7 | Gene Name |
P36544 | UniProt ID |
ION CHANNEL |