DGIdb - CHRNB4 Gene Record

CHRNB4 1143 Druggable Genome

Alternate Names:

1143
CHOLINERGIC RECEPTOR NICOTINIC BETA 4 SUBUNIT
CHRNB4
118509
1964
ENSG00000117971
OTTHUMG00000143860
Neuronal acetylcholine receptor subunit beta-4
P30926
ACHB4_HUMAN
NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, BETA-4 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P30926]
PA26496
Neuronal acetylcholine receptor beta-4
T73724

Gene Info:

Uniprot Status	Swiss-Prot
Interpro Acc	IPR006202
Interpro Name	Neurotransmitter-gated ion-channel ligand-binding
Human Readable Name	ION CHANNEL
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Family
Interpro Short Name	Neur_chan_lig-bd
Interpro Name	Neurotransmitter-gated ion-channel
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR006201
Interpro Short Name	Neur_channel
Target Class	Transporters
Target Subclass	TC:1.A.9
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Winterer G et al., 2010, Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance., Am J Med Genet B Neuropsychiatr Genet
Narahashi et al., 2000, Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior., Toxicol. Sci.
Mansvelder et al., 2009, Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits., Semin. Cell Dev. Biol.
Jackson et al., 2010, Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice., J. Pharmacol. Exp. Ther.
Zaniewska et al., Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives., Pharmacol Rep
Kombo DC et al., 2013, Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the α3β4 nicotinic acetylcholine receptor (nAChR)., Bioorg Med Chem Lett
Fitch RW et al., 2010, Phantasmidine: an epibatidine congener from the ecuadorian poison frog Epipedobates anthonyi., J Nat Prod
Stauderman KA et al., 1998, Characterization of human recombinant neuronal nicotinic acetylcholine receptor subunit combinations alpha2beta4, alpha3beta4 and alpha4beta4 stably expressed in HEK293 cells., J Pharmacol Exp Ther

EPIBATIDINE CHRNB4

Interaction Score: 7.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
20337496 9454827

Sources:
DTC
PHANTASMIDINE CHRNB4

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20337496

Sources:
DTC
CHEMBL2332279 CHRNB4

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23352509

Sources:
DTC
TRIMETHAPHAN CAMSYLATE CHRNB4

Interaction Score: 2.38

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MECAMYLAMINE HYDROCHLORIDE CHRNB4

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOLINIUM TARTRATE CHRNB4

Interaction Score: 2.38

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LARAZOTIDE ACETATE CHRNB4

Interaction Score: 2.38

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 partial agonist

PMIDs:
None found

Sources:
ChemblInteractions
TC-6499 CHRNB4

Interaction Score: 1.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CYTISINICLINE CHRNB4

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
VARENICLINE CHRNB4

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name varenicline, CP-526

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ASM-024 CHRNB4

Interaction Score: 0.68

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
NICOTINE CHRNB4

Interaction Score: 0.59

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
20886544 11006350 19560048 20400469 20081230

Sources:
PharmGKB
COTININE CHRNB4

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000117971
- Version: 101_38
Alternate Names:

CHRNB4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P30926
- Version: 11-September-2012
Alternate Names:

P30926 Uniprot Accession

ENSG00000117971 Ensembl Gene Id

ACHB4_HUMAN Uniprot Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Acc IPR006202

Interpro Name Neurotransmitter-gated ion-channel ligand-binding

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000117971
- Version: 26-July-2011
Alternate Names:

ENSG00000117971 Ensembl Gene Id

CHRNB4 Display Id

NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, BETA-4 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P30926] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P30926
- Version: January-2014
Alternate Names:

CHRNB4 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.9

Publications:
PharmGKB: CHRNB4
- Version: 18-August-2020
Alternate Names:

PA26496 PharmGKB ID

Gene Info:

Publications:

Winterer G et al., 2010, Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance., Am J Med Genet B Neuropsychiatr Genet

DTC: CHRNB4

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Fitch RW et al., 2010, Phantasmidine: an epibatidine congener from the ecuadorian poison frog Epipedobates anthonyi., J Nat Prod

Kombo DC et al., 2013, Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the α3β4 nicotinic acetylcholine receptor (nAChR)., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000117971
- Version: 31-May-2017
Alternate Names:

ENSG00000117971 Gene Symbol

CHRNB4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: CHRNB4
- Version: chembl_23
Alternate Names:

CHRNB4 GENE_SYMBOL

Neuronal acetylcholine receptor subunit beta-4 UNIPROT

Gene Info:

Publications:
TTD: Neuronal acetylcholine receptor beta-4
- Version: 2020.06.01
Alternate Names:

CHRNB4 TTD Gene Abbreviation

T73724 TTD Target ID

Gene Info:

Publications:
Pharos: CHRNB4
- Version: 01-February-2022
Alternate Names:

Neuronal acetylcholine receptor subunit beta-4 Gene Name

P30926 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Mechanism of Interaction	Neuronal acetylcholine receptor; alpha3/beta4 antagonist
Direct Interaction	yes

Trial Name	varenicline, CP-526
Novel drug target	Established target

P30926	Uniprot Accession
ENSG00000117971	Ensembl Gene Id
ACHB4_HUMAN	Uniprot Id

CHRNB4	GENE_SYMBOL
Neuronal acetylcholine receptor subunit beta-4	UNIPROT

Neuronal acetylcholine receptor subunit beta-4	Gene Name
P30926	UniProt ID

CHRNB4 Gene Record

CHRNB4 1143 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 20337496 9454827

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20337496

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23352509

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 partial agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name varenicline, CP-526 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 20886544 11006350 19560048 20400469 20081230

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000117971

Alternate Names: CHRNB4 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P30926

Alternate Names: P30926 Uniprot Accession ENSG00000117971 Ensembl Gene Id ACHB4_HUMAN Uniprot Id

Gene Info: Uniprot Status Swiss-Prot Interpro Acc IPR006202 Interpro Name Neurotransmitter-gated ion-channel ligand-binding

Gene Categories: ION CHANNEL, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000117971

Alternate Names: ENSG00000117971 Ensembl Gene Id CHRNB4 Display Id NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, BETA-4 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P30926] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P30926

Alternate Names: CHRNB4 Gene Symbol

Gene Info: Target Class Transporters Target Subclass TC:1.A.9

Publications:

PharmGKB: CHRNB4

Alternate Names: PA26496 PharmGKB ID

Gene Info:

Publications: Winterer G et al., 2010, Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance., Am J Med Genet B Neuropsychiatr Genet

Interaction Types & Directionality:

agonist (activating)

PMIDs:
20337496 9454827

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20337496

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23352509

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 partial agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name varenicline, CP-526

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor; alpha3/beta4 antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

PMIDs:
20886544 11006350 19560048 20400469 20081230

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

CHRNB4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

P30926 Uniprot Accession

ENSG00000117971 Ensembl Gene Id

ACHB4_HUMAN Uniprot Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Acc IPR006202

Interpro Name Neurotransmitter-gated ion-channel ligand-binding

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Alternate Names:

ENSG00000117971 Ensembl Gene Id

CHRNB4 Display Id

NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, BETA-4 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P30926] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CHRNB4 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.9

Alternate Names:

PA26496 PharmGKB ID

Publications:

Winterer G et al., 2010, Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance., Am J Med Genet B Neuropsychiatr Genet

Alternate Names:

ENSG00000117971 Gene Symbol

CHRNB4 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CHRNB4 GENE_SYMBOL

Neuronal acetylcholine receptor subunit beta-4 UNIPROT

Alternate Names:

CHRNB4 TTD Gene Abbreviation

T73724 TTD Target ID

Alternate Names:

Neuronal acetylcholine receptor subunit beta-4 Gene Name

P30926 UniProt ID

Gene Categories:

ION CHANNEL