DGIdb - CSF2RB Gene Record

CSF2RB 1439 Druggable Genome

Alternate Names:

1439
COLONY STIMULATING FACTOR 2 RECEPTOR BETA COMMON SUBUNIT
CSF2RB
CD131
CDw131
IL3RB
IL5RB
SMDP5
betaGMR
138981
2436
ENSG00000100368
OTTHUMG00000150546
P32927
CD_antigen=CD131
GM-CSF/IL-3/IL-5 receptor common beta subunit
Cytokine receptor common subunit beta
IL3RB_HUMAN
Interleukin 3 receptor
T44589
COLONY STIMULATING FACTOR 2 RECEPTOR SUBUNIT BETA

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	Type 1 cytokine receptor
Transmembrane Helix Count	1
Target Subclass	Type1
Target Subclass	CytokineR
Target Subclass	IG
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Shen et al., 1992, Localization of the human GM-CSF receptor beta chain gene (CSF2RB) to chromosome 22q12.2-->q13.1., Cytogenet. Cell Genet.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

SARGRAMOSTIM CSF2RB

Interaction Score: 46.37

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name sargramostim,L/

Novel drug target Established target

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor receptor agonist

PMIDs:
1424804 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
LERIDISTIM CSF2RB

Interaction Score: 15.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TALACOTUZUMAB CSF2RB

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TAGRAXOFUSP CSF2RB

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000100368
- Version: 101_38
Alternate Names:

CSF2RB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P32927
- Version: January-2014
Alternate Names:

CSF2RB Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Publications:
TEND: P32927
- Version: 01-August-2011
Alternate Names:

ENSG00000100368 Ensembl Gene Id

IL3RB_HUMAN Uniprot Id

CSF2RB Gene Symbol

Gene Info:

Transmembrane Helix Count 1

Target Subclass Type1

Target Subclass CytokineR

Publications:
HingoraniCasas: ENSG00000100368
- Version: 31-May-2017
Alternate Names:

ENSG00000100368 Gene Symbol

CSF2RB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: IL3RB
- Version: chembl_23
Alternate Names:

IL5RB GENE_SYMBOL

CSF2RB GENE_SYMBOL

Cytokine receptor common subunit beta UNIPROT

Gene Info:

Publications:
GO: CSF2RB
- Version: 01-February-2022
Alternate Names:

IL3RB GO Gene Synonym

IL5RB GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Interleukin 3 receptor
- Version: 2020.06.01
Alternate Names:

CSF2RB TTD Gene Abbreviation

T44589 TTD Target ID

Gene Info:

Publications:

Trial Name	sargramostim,L/
Novel drug target	Established target
Mechanism of Interaction	Granulocyte-macrophage colony-stimulating factor receptor agonist

ENSG00000100368	Ensembl Gene Id
IL3RB_HUMAN	Uniprot Id
CSF2RB	Gene Symbol

IL5RB	GENE_SYMBOL
CSF2RB	GENE_SYMBOL
Cytokine receptor common subunit beta	UNIPROT

CSF2RB Gene Record

CSF2RB 1439 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

SARGRAMOSTIM CSF2RB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name sargramostim,L/ Novel drug target Established target Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor receptor agonist

PMIDs: 1424804 17016423 17139284

Sources: TdgClinicalTrial ChemblInteractions TEND

LERIDISTIM CSF2RB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TALACOTUZUMAB CSF2RB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TAGRAXOFUSP CSF2RB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Ensembl: ENSG00000100368

Alternate Names: CSF2RB Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P32927

Alternate Names: CSF2RB Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass Type 1 cytokine receptor

Publications:

TEND: P32927

Alternate Names: ENSG00000100368 Ensembl Gene Id IL3RB_HUMAN Uniprot Id CSF2RB Gene Symbol

Gene Info: Transmembrane Helix Count 1 Target Subclass Type1 Target Subclass CytokineR

Publications:

HingoraniCasas: ENSG00000100368

Alternate Names: ENSG00000100368 Gene Symbol CSF2RB Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: IL3RB

Alternate Names: IL5RB GENE_SYMBOL CSF2RB GENE_SYMBOL Cytokine receptor common subunit beta UNIPROT

Gene Info:

Publications:

GO: CSF2RB

Alternate Names: IL3RB GO Gene Synonym IL5RB GO Gene Synonym

Gene Info:

Gene Categories: EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

TTD: Interleukin 3 receptor

Alternate Names: CSF2RB TTD Gene Abbreviation T44589 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name sargramostim,L/

Novel drug target Established target

Mechanism of Interaction Granulocyte-macrophage colony-stimulating factor receptor agonist

PMIDs:
1424804 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

CSF2RB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CSF2RB Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Alternate Names:

ENSG00000100368 Ensembl Gene Id

IL3RB_HUMAN Uniprot Id

CSF2RB Gene Symbol

Gene Info:

Transmembrane Helix Count 1

Target Subclass Type1

Target Subclass CytokineR

Alternate Names:

ENSG00000100368 Gene Symbol

CSF2RB Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

IL5RB GENE_SYMBOL

CSF2RB GENE_SYMBOL

Cytokine receptor common subunit beta UNIPROT

Alternate Names:

IL3RB GO Gene Synonym

IL5RB GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

CSF2RB TTD Gene Abbreviation

T44589 TTD Target ID