DGIdb - CXCR2 Gene Record

CXCR2 3579 Druggable Genome

Alternate Names:

3579
C-X-C MOTIF CHEMOKINE RECEPTOR 2
CXCR2
CD182
CDw128b
CMKAR2
IL8R2
IL8RA
IL8RB
146928
6027
ENSG00000180871
OTTHUMG00000133107
High affinity interleukin-8 receptor B
CXCR-2
GRO/MGSA receptor
CD_antigen=CD182
IL-8R B
CXC-R2
C-X-C chemokine receptor type 2
IL-8 receptor type 2
P25025
CXCR2_HUMAN
HIGH AFFINITY INTERLEUKIN-8 RECEPTOR B (IL-8R B) (CXCR-2) (GRO/MGSA RECEPTOR) (IL-8 RECEPTOR TYPE 2) (CDW128B). [SOURCE:UNIPROT/SWISSPROT;ACC:P25025]
T56923
WHIMS2

Gene Info:

Human Readable Name	G PROTEIN COUPLED RECEPTOR
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Interpro Type	Family
Interpro Acc	IPR000276
Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

CELL SURFACE
G PROTEIN COUPLED RECEPTOR
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Saccani et al., 2000, Redox regulation of chemokine receptor expression., Proc. Natl. Acad. Sci. U.S.A.
Dwyer MP et al., 2006, Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist., J Med Chem
Yang et al., 2006, Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial., Eur. J. Cancer Prev.
Khandaker et al., 1998, CXCR1 and CXCR2 are rapidly down-modulated by bacterial endotoxin through a unique agonist-independent, tyrosine kinase-dependent mechanism., J. Immunol.

ELUBRIXIN CXCR2

Interaction Score: 11.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Interleukin-8 receptor B antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
DANIRIXIN CXCR2

Interaction Score: 11.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-8 receptor B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
NAVARIXIN CXCR2

Interaction Score: 9.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name SCH-527123, PS-291822, PS-938285

Novel drug target Novel Target

Mechanism of Interaction Interleukin-8 receptor B antagonist

PMIDs:
17181143

Sources:
DTC TdgClinicalTrial ChemblInteractions TTD
REPARIXIN CXCR2

Interaction Score: 5.62

Interaction Types & Directionality:

allosteric modulator

modulator

Interaction Info:

Mechanism of Interaction Interleukin-8 receptor B modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
LADARIXIN CXCR2

Interaction Score: 2.81

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Interleukin-8 receptor B modulator

PMIDs:
None found

Sources:
ChemblInteractions
NAVARIXIN CXCR2

Interaction Score: 2.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Interleukin-8 receptor B antagonist

PMIDs:
None found

Sources:
ChemblInteractions
VITAMIN E CXCR2

Interaction Score: 1.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16679868

Sources:
NCI
ACETYLCYSTEINE CXCR2

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10716998

Sources:
NCI
GENISTEIN CXCR2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9712063

Sources:
NCI
CLOTRIMAZOLE CXCR2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
IBUPROFEN CXCR2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000180871
- Version: 101_38
Alternate Names:

CXCR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P25025
- Version: January-2014
Alternate Names:

CXCR2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:

RussLampel: ENSG00000180871

Version: 26-July-2011

Alternate Names:

ENSG00000180871 Ensembl Gene Id

IL8RB Display Id

HIGH AFFINITY INTERLEUKIN-8 RECEPTOR B (IL-8R B) (CXCR-2) (GRO/MGSA RECEPTOR) (IL-8 RECEPTOR TYPE 2) (CDW128B). [SOURCE:UNIPROT/SWISSPROT;ACC:P25025] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P25025
- Version: 11-September-2012
Alternate Names:

CXCR2_HUMAN Uniprot Id

CXCR2 Uniprot Gene Name

ENSG00000180871 Ensembl Gene Id

Gene Info:

Interpro Type Family

Interpro Acc IPR000276

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

NCI: IL8RB

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Milatovic et al., Impaired healing of nitrogen mustard wounds in CXCR2 null mice., Wound Repair Regen

Saccani et al., 2000, Redox regulation of chemokine receptor expression., Proc. Natl. Acad. Sci. U.S.A.

Yang et al., 2006, Genetic variation in interleukin 8 and its receptor genes and its influence on the risk and prognosis of prostate cancer among Finnish men in a large cancer prevention trial., Eur. J. Cancer Prev.

DTC: CXCR2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Dwyer MP et al., 2006, Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist., J Med Chem

ChemblInteractions: IL8RB
- Version: chembl_23
Alternate Names:

CD_antigen=CD182 UNIPROT

IL8RB GENE_SYMBOL

CXCR2 GENE_SYMBOL

Gene Info:

Publications:
HingoraniCasas: ENSG00000180871
- Version: 31-May-2017
Alternate Names:

ENSG00000180871 Gene Symbol

CXCR2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: CXCR2
- Version: 01-February-2022
Alternate Names:

IL8RB GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, G PROTEIN COUPLED RECEPTOR, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
dGene: CXCR2
- Version: 27-Jun-2013
Alternate Names:

3579 Gene ID

CD182 dGene Synonym

CDw128b dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: C-X-C chemokine receptor type 2
- Version: 2020.06.01
Alternate Names:

CXCR2 TTD Gene Abbreviation

T56923 TTD Target ID

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Interleukin-8 receptor B antagonist

Trial Name	SCH-527123, PS-291822, PS-938285
Novel drug target	Novel Target
Mechanism of Interaction	Interleukin-8 receptor B antagonist

Mechanism of Interaction	Interleukin-8 receptor B modulator
Direct Interaction	yes

ENSG00000180871	Ensembl Gene Id
IL8RB	Display Id
HIGH AFFINITY INTERLEUKIN-8 RECEPTOR B (IL-8R B) (CXCR-2) (GRO/MGSA RECEPTOR) (IL-8 RECEPTOR TYPE 2) (CDW128B). [SOURCE:UNIPROT/SWISSPROT;ACC:P25025]	Description

CXCR2_HUMAN	Uniprot Id
CXCR2	Uniprot Gene Name
ENSG00000180871	Ensembl Gene Id

CXCR2 Gene Record

CXCR2 3579 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Interleukin-8 receptor B antagonist

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-8 receptor B antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name SCH-527123, PS-291822, PS-938285 Novel drug target Novel Target Mechanism of Interaction Interleukin-8 receptor B antagonist

PMIDs: 17181143

Sources: DTC TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: allosteric modulator modulator

Interaction Info: Mechanism of Interaction Interleukin-8 receptor B modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Interleukin-8 receptor B modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Interleukin-8 receptor B antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16679868

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10716998

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9712063

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Ensembl: ENSG00000180871

Alternate Names: CXCR2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P25025

Alternate Names: CXCR2 Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin

Publications:

RussLampel: ENSG00000180871

Alternate Names: ENSG00000180871 Ensembl Gene Id IL8RB Display Id HIGH AFFINITY INTERLEUKIN-8 RECEPTOR B (IL-8R B) (CXCR-2) (GRO/MGSA RECEPTOR) (IL-8 RECEPTOR TYPE 2) (CDW128B). [SOURCE:UNIPROT/SWISSPROT;ACC:P25025] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: P25025

Alternate Names: CXCR2_HUMAN Uniprot Id CXCR2 Uniprot Gene Name ENSG00000180871 Ensembl Gene Id

Gene Info: Interpro Type Family Interpro Acc IPR000276 Uniprot Status Swiss-Prot

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

NCI: IL8RB

Alternate Names:

Gene Info:

DTC: CXCR2

Alternate Names:

Gene Info:

Publications: Dwyer MP et al., 2006, Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist., J Med Chem

ChemblInteractions: IL8RB

Alternate Names: CD_antigen=CD182 UNIPROT IL8RB GENE_SYMBOL CXCR2 GENE_SYMBOL

Gene Info:

Publications:

HingoraniCasas: ENSG00000180871

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Interleukin-8 receptor B antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-8 receptor B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name SCH-527123, PS-291822, PS-938285

Novel drug target Novel Target

Mechanism of Interaction Interleukin-8 receptor B antagonist

PMIDs:
17181143

Sources:
DTC TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

allosteric modulator

modulator

Interaction Info:

Mechanism of Interaction Interleukin-8 receptor B modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Interleukin-8 receptor B modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Interleukin-8 receptor B antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16679868

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10716998

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9712063

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

CXCR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

CXCR2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

ENSG00000180871 Ensembl Gene Id

IL8RB Display Id

HIGH AFFINITY INTERLEUKIN-8 RECEPTOR B (IL-8R B) (CXCR-2) (GRO/MGSA RECEPTOR) (IL-8 RECEPTOR TYPE 2) (CDW128B). [SOURCE:UNIPROT/SWISSPROT;ACC:P25025] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CXCR2_HUMAN Uniprot Id

CXCR2 Uniprot Gene Name

ENSG00000180871 Ensembl Gene Id

Gene Info:

Interpro Type Family

Interpro Acc IPR000276

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

Dwyer MP et al., 2006, Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist., J Med Chem

Alternate Names:

CD_antigen=CD182 UNIPROT

IL8RB GENE_SYMBOL

CXCR2 GENE_SYMBOL

Alternate Names:

ENSG00000180871 Gene Symbol

CXCR2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

IL8RB GO Gene Synonym

Gene Categories:

CELL SURFACE, G PROTEIN COUPLED RECEPTOR, EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

3579 Gene ID

CD182 dGene Synonym

CDw128b dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

CXCR2 TTD Gene Abbreviation

T56923 TTD Target ID