DGIdb - CYSLTR1 Gene Record

CYSLTR1 10800 Druggable Genome

Alternate Names:

10800
CYSTEINYL LEUKOTRIENE RECEPTOR 1
CYSLTR1
CYSLT1
CYSLT1R
CYSLTR
HMTMF81
300201
17451
ENSG00000173198
OTTHUMG00000021889
LTD4 receptor
Cysteinyl leukotriene D4 receptor
G-protein coupled receptor HG55
Q9Y271
HG55
CLTR1_HUMAN
CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLTR1) (CYSTEINYL LEUKOTRIENE D4 RECEPTOR) (LTD4 RECEPTOR) (HG55) (HMTMF81). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y271]
PA38453
Leukotriene CysLT1 receptor
T71192

Gene Info:

Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Transmembrane Helix Count	7
Target Main Class	Receptors
Interpro Acc	IPR000276
Uniprot Evidence	2: Evidence at transcript level
Uniprot Status	Swiss-Prot
Interpro Type	Family
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Name	GPCR, rhodopsin-like, 7TM
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Cazzola et al., 2000, Lung function improvement in smokers suffering from COPD with zafirlukast, a CysLT(1)-receptor antagonist., Pulm Pharmacol Ther
Heise et al., 2000, Characterization of the human cysteinyl leukotriene 2 receptor., J. Biol. Chem.
O'Byrne, 1997, Leukotrienes in the pathogenesis of asthma., Chest
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Wang et al., 2000, A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization., J. Biol. Chem.
Murata et al., 2002, [Zafirlukast (Accolate): a review of its pharmacological and clinical profile]., Nippon Yakurigaku Zasshi
Nayak, 2004, A review of montelukast in the treatment of asthma and allergic rhinitis., Expert Opin Pharmacother
Alfieri et al., 2007, Heterogeneous effect of leucotriene CysLT1 receptor antagonists on antigen-induced motor and inflammatory responses in guinea-pig airways., Auton Autacoid Pharmacol
Langlois et al., 2006, Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism., J. Allergy Clin. Immunol.
Hamacher et al., 2007, Montelukast exerts no acute direct effect on NO synthases., Pulm Pharmacol Ther
Zhang et al., 2004, Montelukast modulates lung CysLT(1) receptor expression and eosinophilic inflammation in asthmatic mice., Acta Pharmacol. Sin.
Adelroth et al., 1997, Prolonged protection against exercise-induced bronchoconstriction by the leukotriene D4-receptor antagonist cinalukast., J. Allergy Clin. Immunol.
Foller et al., 2009, Participation of leukotriene C(4) in the regulation of suicidal erythrocyte death., J. Physiol. Pharmacol.
Ogasawara et al., 2002, Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution., J. Biol. Chem.
Shirasaki et al., 2006, Distribution of specific binding sites for cysteinyl leukotriene 1 receptor antagonist in human nasal mucosa., Acta Otolaryngol.
Ishinaga et al., 2005, Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells., Pharmacology
Yoo et al., 2001, Clinical effects of pranlukast, an oral leukotriene receptor antagonist, in mild-to-moderate asthma: a 4 week randomized multicentre controlled trial., Respirology
Ding et al., 2006, Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice., Acta Pharmacol. Sin.
Radeau et al., 1993, Effect of nedocromil sodium on sulfidopeptide leukotrienes-stimulated human alveolar macrophages in asthma., Pulm Pharmacol
Yazid et al., 2010, Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization., Arterioscler. Thromb. Vasc. Biol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Monteseirín et al., 2005, L-selectin expression on neutrophils from allergic patients., Clin. Exp. Allergy

PRANLUKAST CYSLTR1

Interaction Score: 61.83

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11854273 16864492 15475658 11752352 11264758 17112405

Sources:
TdgClinicalTrial TEND PharmGKB TTD
NEDOCROMIL CYSLTR1

Interaction Score: 21.64

Interaction Types & Directionality:

suppressor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8386571 20558817 17016423 17139284 16164449

Sources:
TdgClinicalTrial TEND
CR-3465 CYSLTR1

Interaction Score: 12.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
CINALUKAST CYSLTR1

Interaction Score: 12.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9042047 19826192 11752352

Sources:
TdgClinicalTrial TEND TTD
IRALUKAST CYSLTR1

Interaction Score: 6.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
ZAFIRLUKAST CYSLTR1

Interaction Score: 4.86

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist

Direct Interaction yes

Trial Name zafirlukast,Accolate

PMIDs:
11061985 10851239 9042024 11752352 11006272 11979731

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
MONTELUKAST CYSLTR1

Interaction Score: 3.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name loratadine + montelukast sodium,Claritin + Singulair

Novel drug target Established target

Trial Name montelukast sodium,Singulair

PMIDs:
15013935 17199874 16815146 11752352 16815057 15456537

Sources:
TdgClinicalTrial TEND PharmGKB TTD
LY-2300559 CYSLTR1

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL314115 CYSLTR1

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MONTELUKAST SODIUM CYSLTR1

Interaction Score: 1.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000173198
- Version: 101_38
Alternate Names:

CYSLTR1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000173198

Version: 26-July-2011

Alternate Names:

ENSG00000173198 Ensembl Gene Id

CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLTR1) (CYSTEINYL LEUKOTRIENE D4 RECEPTOR) (LTD4 RECEPTOR) (HG55) (HMTMF81). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y271] Description

CYSLTR1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: Q9Y271
- Version: 01-August-2011
Alternate Names:

10800 Entrez Gene Id

CLTR1_HUMAN Uniprot Id

CYSLTR1 Gene Symbol

Gene Info:

Transmembrane Helix Count 7

Target Main Class Receptors

Target Subclass GPCR

Publications:
TdgClinicalTrial: Q9Y271
- Version: January-2014
Alternate Names:

CYSLTR1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: Q9Y271
- Version: 11-September-2012
Alternate Names:

ENSG00000173198 Ensembl Gene Id

Q9Y271 Uniprot Accession

CLTR1_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR000276

Uniprot Evidence 2: Evidence at transcript level

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
NCI: CYSLTR1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Asakura et al., 2004, Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta., J. Allergy Clin. Immunol.
ChemblInteractions: CYSLT1
- Version: chembl_23
Alternate Names:

CYSLT1 GENE_SYMBOL

CYSLTR1 GENE_SYMBOL

Cysteinyl leukotriene receptor 1 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000173198
- Version: 31-May-2017
Alternate Names:

ENSG00000173198 Gene Symbol

CYSLTR1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: CYSLTR1
- Version: 18-August-2020
Alternate Names:

PA38453 PharmGKB ID

Gene Info:

Publications:
dGene: CYSLTR1
- Version: 27-Jun-2013
Alternate Names:

10800 Gene ID

CYSLT1 dGene Synonym

CYSLT1R dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Leukotriene CysLT1 receptor
- Version: 2020.06.01
Alternate Names:

CYSLTR1 TTD Gene Abbreviation

T71192 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Cysteinyl leukotriene receptor 1 antagonist
Direct Interaction	yes

Trial Name	loratadine + montelukast sodium,Claritin + Singulair
Novel drug target	Established target
Trial Name	montelukast sodium,Singulair

ENSG00000173198	Ensembl Gene Id
CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLTR1) (CYSTEINYL LEUKOTRIENE D4 RECEPTOR) (LTD4 RECEPTOR) (HG55) (HMTMF81). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y271]	Description
CYSLTR1	Display Id

CYSLT1	GENE_SYMBOL
CYSLTR1	GENE_SYMBOL
Cysteinyl leukotriene receptor 1	UNIPROT

CYSLTR1 Gene Record

CYSLTR1 10800 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11854273 16864492 15475658 11752352 11264758 17112405

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: suppressor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8386571 20558817 17016423 17139284 16164449

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9042047 19826192 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist Direct Interaction yes Trial Name zafirlukast,Accolate

PMIDs: 11061985 10851239 9042024 11752352 11006272 11979731

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name loratadine + montelukast sodium,Claritin + Singulair Novel drug target Established target Trial Name montelukast sodium,Singulair

PMIDs: 15013935 17199874 16815146 11752352 16815057 15456537

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000173198

Alternate Names: CYSLTR1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000173198

Alternate Names: ENSG00000173198 Ensembl Gene Id CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLTR1) (CYSTEINYL LEUKOTRIENE D4 RECEPTOR) (LTD4 RECEPTOR) (HG55) (HMTMF81). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y271] Description CYSLTR1 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: Q9Y271

Alternate Names: 10800 Entrez Gene Id CLTR1_HUMAN Uniprot Id CYSLTR1 Gene Symbol

Gene Info: Transmembrane Helix Count 7 Target Main Class Receptors Target Subclass GPCR

Publications:

TdgClinicalTrial: Q9Y271

Alternate Names: CYSLTR1 Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin

Publications:

HopkinsGroom: Q9Y271

Alternate Names: ENSG00000173198 Ensembl Gene Id Q9Y271 Uniprot Accession CLTR1_HUMAN Uniprot Id

Gene Info: Interpro Acc IPR000276 Uniprot Evidence 2: Evidence at transcript level Uniprot Status Swiss-Prot

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

NCI: CYSLTR1

Alternate Names:

Gene Info:

Publications: Asakura et al., 2004, Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta., J. Allergy Clin. Immunol.

ChemblInteractions: CYSLT1

Alternate Names: CYSLT1 GENE_SYMBOL CYSLTR1 GENE_SYMBOL Cysteinyl leukotriene receptor 1 UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000173198

Alternate Names: ENSG00000173198 Gene Symbol CYSLTR1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11854273 16864492 15475658 11752352 11264758 17112405

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

suppressor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8386571 20558817 17016423 17139284 16164449

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9042047 19826192 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist

Direct Interaction yes

Trial Name zafirlukast,Accolate

PMIDs:
11061985 10851239 9042024 11752352 11006272 11979731

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name loratadine + montelukast sodium,Claritin + Singulair

Novel drug target Established target

Trial Name montelukast sodium,Singulair

PMIDs:
15013935 17199874 16815146 11752352 16815057 15456537

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Cysteinyl leukotriene receptor 1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

CYSLTR1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000173198 Ensembl Gene Id

CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLTR1) (CYSTEINYL LEUKOTRIENE D4 RECEPTOR) (LTD4 RECEPTOR) (HG55) (HMTMF81). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9Y271] Description

CYSLTR1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

10800 Entrez Gene Id

CLTR1_HUMAN Uniprot Id

CYSLTR1 Gene Symbol

Gene Info:

Transmembrane Helix Count 7

Target Main Class Receptors

Target Subclass GPCR

Alternate Names:

CYSLTR1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

ENSG00000173198 Ensembl Gene Id

Q9Y271 Uniprot Accession

CLTR1_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR000276

Uniprot Evidence 2: Evidence at transcript level

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

Asakura et al., 2004, Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta., J. Allergy Clin. Immunol.

Alternate Names:

CYSLT1 GENE_SYMBOL

CYSLTR1 GENE_SYMBOL

Cysteinyl leukotriene receptor 1 UNIPROT

Alternate Names:

ENSG00000173198 Gene Symbol

CYSLTR1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA38453 PharmGKB ID

Alternate Names:

10800 Gene ID

CYSLT1 dGene Synonym

CYSLT1R dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

CYSLTR1 TTD Gene Abbreviation

T71192 TTD Target ID