DGIdb - DPEP1 Gene Record

DPEP1 1800 Druggable Genome

Alternate Names:

1800
DIPEPTIDASE 1
DPEP1
MBD1
MDP
RDP
179780
3002
ENSG00000015413
OTTHUMG00000138052
P16444
hRDP
Microsomal dipeptidase
Dehydropeptidase-I
Renal dipeptidase
DPEP1_HUMAN
DEHYDROPEPTIDASE I
T41201

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.4.13
Target Subclass	3.4.13
Transmembrane Helix Count	1
Target Main Class	Enzymes
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

PROTEASE
DRUGGABLE GENOME
ENZYME

Publications:

Farrell et al., 1987, Cilastatin-sensitive dehydropeptidase I enzymes from three sources all catalyze carbapenem hydrolysis and conversion of leukotriene D4 to leukotriene E4., Arch. Biochem. Biophys.
Keynan et al., 1995, The renal membrane dipeptidase (dehydropeptidase I) inhibitor, cilastatin, inhibits the bacterial metallo-beta-lactamase enzyme CphA., Antimicrob. Agents Chemother.
Kumon et al., 1987, [Effects of cilastatin sodium, an inhibitor of dehydropeptidase-I, on human urinary peptide excretion. Patients with renal insufficiency]., Jpn J Antibiot
Hirota et al., 1987, Role of dehydropeptidase-I in the metabolism of glutathione and its conjugates in the rat kidney., Res. Commun. Chem. Pathol. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Lin et al., Dose-dependent kinetics of cilastatin in laboratory animals., Drug Metab. Dispos.
Richerson et al., 1998, Formulary review of the carbapenems: comparison of imipenem/cilastatin and meropenem., Conn Med
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Hirota et al., 1986, Characterization of dehydropeptidase I in the rat lung., Eur. J. Biochem.
Höfken et al., 1998, Membrane dipeptidase and glutathione are major components of pig pancreatic zymogen granules., Exp. Cell Res.

CILASTATIN DPEP1

Interaction Score: 267.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
3038022 7492120 3480361 3474745 11752352 2571484 9573653 17016423 17139284 3780719

Sources:
TdgClinicalTrial TEND TTD
CILASTATIN SODIUM DPEP1

Interaction Score: 20.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Renal dipeptidase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DEXAMETHASONE DPEP1

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9806799

Sources:
NCI

Ensembl: ENSG00000015413
- Version: 101_38
Alternate Names:

DPEP1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P16444
- Version: January-2014
Alternate Names:

DPEP1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.13

Publications:
TEND: P16444
- Version: 01-August-2011
Alternate Names:

ENSG00000015413 Ensembl Gene Id

P16444 Uniprot Accession

DPEP1_HUMAN Uniprot Id

Gene Info:

Transmembrane Helix Count 1

Target Main Class Enzymes

Target Subclass 3.4.13

Publications:
NCI: DPEP1
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Höfken et al., 1998, Membrane dipeptidase and glutathione are major components of pig pancreatic zymogen granules., Exp. Cell Res.
HingoraniCasas: ENSG00000015413
- Version: 31-May-2017
Alternate Names:

ENSG00000015413 Gene Symbol

DPEP1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: MDP
- Version: chembl_23
Alternate Names:

RDP GENE_SYMBOL

DPEP1 GENE_SYMBOL

Dipeptidase 1 UNIPROT

Gene Info:

Publications:
dGene: DPEP1
- Version: 27-Jun-2013
Alternate Names:

1800 Gene ID

MBD1 dGene Synonym

MDP dGene Synonym

Gene Info:

Gene Categories:

PROTEASE

Publications:
TTD: Dehydropeptidase I
- Version: 2020.06.01
Alternate Names:

DPEP1 TTD Gene Abbreviation

T41201 TTD Target ID

Gene Info:

Publications:
Pharos: DPEP1
- Version: 01-February-2022
Alternate Names:

Dipeptidase 1 Gene Name

P16444 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Direct Interaction	yes
Mechanism of Interaction	Renal dipeptidase inhibitor

ENSG00000015413	Ensembl Gene Id
P16444	Uniprot Accession
DPEP1_HUMAN	Uniprot Id

Trial Name	-
Novel drug target	Established target

RDP	GENE_SYMBOL
DPEP1	GENE_SYMBOL
Dipeptidase 1	UNIPROT

1800	Gene ID
MBD1	dGene Synonym
MDP	dGene Synonym

Dipeptidase 1	Gene Name
P16444	UniProt ID

DPEP1 Gene Record

DPEP1 1800 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CILASTATIN DPEP1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 3038022 7492120 3480361 3474745 11752352 2571484 9573653 17016423 17139284 3780719

Sources: TdgClinicalTrial TEND TTD

CILASTATIN SODIUM DPEP1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Renal dipeptidase inhibitor

PMIDs: None found

Sources: ChemblInteractions

DEXAMETHASONE DPEP1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9806799

Sources: NCI

Ensembl: ENSG00000015413

Alternate Names: DPEP1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P16444

Alternate Names: DPEP1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.4.13

Publications:

TEND: P16444

Alternate Names: ENSG00000015413 Ensembl Gene Id P16444 Uniprot Accession DPEP1_HUMAN Uniprot Id

Gene Info: Transmembrane Helix Count 1 Target Main Class Enzymes Target Subclass 3.4.13

Publications:

NCI: DPEP1

Alternate Names:

Gene Info:

Publications: Höfken et al., 1998, Membrane dipeptidase and glutathione are major components of pig pancreatic zymogen granules., Exp. Cell Res.

HingoraniCasas: ENSG00000015413

Alternate Names: ENSG00000015413 Gene Symbol DPEP1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: MDP

Alternate Names: RDP GENE_SYMBOL DPEP1 GENE_SYMBOL Dipeptidase 1 UNIPROT

Gene Info:

Publications:

dGene: DPEP1

Alternate Names: 1800 Gene ID MBD1 dGene Synonym MDP dGene Synonym

Gene Info:

Gene Categories: PROTEASE

Publications:

TTD: Dehydropeptidase I

Alternate Names: DPEP1 TTD Gene Abbreviation T41201 TTD Target ID

Gene Info:

Publications:

Pharos: DPEP1

Alternate Names: Dipeptidase 1 Gene Name P16444 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
3038022 7492120 3480361 3474745 11752352 2571484 9573653 17016423 17139284 3780719

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Renal dipeptidase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
9806799

Sources:
NCI

Alternate Names:

DPEP1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

DPEP1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.4.13

Alternate Names:

ENSG00000015413 Ensembl Gene Id

P16444 Uniprot Accession

DPEP1_HUMAN Uniprot Id

Gene Info:

Transmembrane Helix Count 1

Target Main Class Enzymes

Target Subclass 3.4.13

Publications:

Höfken et al., 1998, Membrane dipeptidase and glutathione are major components of pig pancreatic zymogen granules., Exp. Cell Res.

Alternate Names:

ENSG00000015413 Gene Symbol

DPEP1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

RDP GENE_SYMBOL

DPEP1 GENE_SYMBOL

Dipeptidase 1 UNIPROT

Alternate Names:

1800 Gene ID

MBD1 dGene Synonym

MDP dGene Synonym

Gene Categories:

PROTEASE

Alternate Names:

DPEP1 TTD Gene Abbreviation

T41201 TTD Target ID

Alternate Names:

Dipeptidase 1 Gene Name

P16444 UniProt ID

Gene Categories:

ENZYME