DGIdb - DRD4 Gene Record

DRD4 1815 Druggable Genome

Alternate Names:

1815
DOPAMINE RECEPTOR D4
DRD4
D4DR
126452
3025
ENSG00000069696
OTTHUMG00000133312
DOPAMINE RECEPTOR D4 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_000788]
NP_000788.2
P21917
D(4) dopamine receptor
D(2C) dopamine receptor
Dopamine D4 receptor
DRD4_HUMAN
D4R
T24983

Gene Info:

Human Readable Name	G PROTEIN COUPLED RECEPTOR
Human Readable Name	DRUGGABLE GENOME
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Interpro Type	Family
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000276
Uniprot Evidence	1: Evidence at protein level
Transmembrane Helix Count	7
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Patel et al., 2003, Pharmacological and functional characterisation of dopamine D4 receptors in the rat retina., Neuropharmacology
Glatt et al., 2003, Schizophrenia is not associated with DRD4 48-base-pair-repeat length or individual alleles: results of a meta-analysis., Biol. Psychiatry
Zhao et al., 2005, Dopamine D4 receptor gene exon III polymorphism and interindividual variation in response to clozapine., Int. J. Neurosci.
Nakane et al., 2005, 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist., Neuropharmacology
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kuballa et al., Central effects of nafadotride, a dopamine D3 receptor antagonist, in rats. Comparison with haloperidol and clozapine., Pharmacol Rep
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
Roth et al., 1995, D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs., Psychopharmacology (Berl.)
Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
Dooley M et al., 1998, Pramipexole. A review of its use in the management of early and advanced Parkinson's disease., Drugs Aging
Mierau et al., 1995, Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors., Eur. J. Pharmacol.
Piercey MF, 1998, Pharmacology of pramipexole, a dopamine D3-preferring agonist useful in treating Parkinson's disease., Clin Neuropharmacol
Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Burstein et al., 2005, Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist., J. Pharmacol. Exp. Ther.
Hutchison et al., 2006, The effect of olanzapine on craving and alcohol consumption., Neuropsychopharmacology
Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
Shill HA et al., 2009, Update on ropinirole in the treatment of Parkinson's disease., Neuropsychiatr Dis Treat
Boeckler et al., 2004, FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia., Psychopharmacology (Berl.)
Sanner et al., 1998, Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist., Bioorg. Med. Chem. Lett.
Mansbach et al., 1998, Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition., Psychopharmacology (Berl.)
Melis et al., 2006, PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain., Eur. J. Neurosci.
Succu et al., 2007, Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: Involvement of central oxytocin., Neuropharmacology
LeWitt PA, 2004, Subcutaneously administered apomorphine: pharmacokinetics and metabolism., Neurology
Koller et al., 1998, Mechanism of action of dopaminergic agents in Parkinson's disease., Neurology
Onofrj et al., 2008, An expert opinion on safinamide in Parkinson's disease., Expert Opin Investig Drugs
Deleu et al., 2002, Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease., Clin Pharmacokinet

PRAMIPEXOLE DRD4

Interaction Score: 3.43

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Mirapex

Novel drug target Established target

PMIDs:
18691132 11752352 9638397 7664822 9617505

Sources:
TdgClinicalTrial TEND
ROPINIROLE DRD4

Interaction Score: 1.47

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name JZP-7

Novel drug target Established target

PMIDs:
18691132 11752352 19557097

Sources:
TdgClinicalTrial
APOMORPHINE DRD4

Interaction Score: 1.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name intranasal apomorphine

Trial Name inhaled apomorphine hydrochloride, VR004, VR-040, VR-400

Trial Name apomorphine hydrochloride,Apokyn, APO-go

PMIDs:
15007532 9871530 9497025 17067298 11752352 17164075 18691132 15037665

Sources:
TdgClinicalTrial TEND
ROTIGOTINE DRD4

Interaction Score: 0.88

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction D2-like dopamine receptor agonist

Trial Name Neupro

PMIDs:
18691132

Sources:
TdgClinicalTrial ChemblInteractions
THIETHYLPERAZINE DRD4

Interaction Score: 0.54

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
APOMORPHINE HYDROCHLORIDE DRD4

Interaction Score: 0.49

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction D2-like dopamine receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
DEXPRAMIPEXOLE DRD4

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name dexpramipexole, KNS-760704

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
PRAMIPEXOLE DIHYDROCHLORIDE DRD4

Interaction Score: 0.49

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PROPIOMAZINE DRD4

Interaction Score: 0.42

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
PHENYLTOLOXAMINE DRD4

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
HALOPERIDOL DECANOATE DRD4

Interaction Score: 0.37

Interaction Types & Directionality:

inverse agonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor inverse agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ROPINIROLE HYDROCHLORIDE DRD4

Interaction Score: 0.37

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SARIZOTAN HYDROCHLORIDE DRD4

Interaction Score: 0.37

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Dopamine D4 receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
ZICRONAPINE DRD4

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name LU-31130

PMIDs:
None found

Sources:
TdgClinicalTrial
HALOPERIDOL LACTATE DRD4

Interaction Score: 0.37

Interaction Types & Directionality:

inverse agonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction D2-like dopamine receptor inverse agonist

PMIDs:
None found

Sources:
ChemblInteractions
PROMAZINE DRD4

Interaction Score: 0.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
ZIPRASIDONE DRD4

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17016423 17139284 17848919

Sources:
TEND
ASENAPINE DRD4

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 10592235 21655346

Sources:
TdgClinicalTrial
OLANZAPINE PAMOATE DRD4

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LOXAPINE HYDROCHLORIDE DRD4

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETILEVODOPA DRD4

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name etilevodopa, TV-1203

PMIDs:
None found

Sources:
TdgClinicalTrial
LOXAPINE DRD4

Interaction Score: 0.25

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DROPERIDOL DRD4

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LOXAPINE SUCCINATE DRD4

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CLOZAPINE DRD4

Interaction Score: 0.22

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
12763097 13129658 16223700 15992586 11752352 15886414

Sources:
TdgClinicalTrial TEND TTD
PERGOLIDE MESYLATE DRD4

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PARDOPRUNOX DRD4

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pardoprunox, SLV 308

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
MELEVODOPA DRD4

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name V-1512, CHF-1512,Levomet Complex, Sirio

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
BROMOCRIPTINE MESYLATE DRD4

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMOXAPINE DRD4

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Dopamine receptor antagonist

PMIDs:
16135699

Sources:
ChemblInteractions
LEVOMEPROMAZINE DRD4

Interaction Score: 0.21

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
15701205

Sources:
ChemblInteractions
PROMAZINE HYDROCHLORIDE DRD4

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEVODOPA DRD4

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name entacapone/levodopa/carbidopa,Stalevo

Novel drug target Established target

Trial Name levodopa + carbidopa,Duodopa

PMIDs:
9633680 18549347 11978145

Sources:
TdgClinicalTrial
CHLORPROMAZINE DRD4

Interaction Score: 0.14

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs:
8524985

Sources:
ChemblInteractions
TRIFLUOPERAZINE HYDROCHLORIDE DRD4

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OLANZAPINE DRD4

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv

PMIDs:
16237394 11752352 25032030

Sources:
TdgClinicalTrial ChemblInteractions TEND
ERGOLOID MESYLATES DRD4

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THIORIDAZINE HYDROCHLORIDE DRD4

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
THIORIDAZINE DRD4

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
CHLORPROMAZINE HYDROCHLORIDE DRD4

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PIMOZIDE DRD4

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HALOPERIDOL DRD4

Interaction Score: 0.02

Interaction Types & Directionality:

inverse agonist (inhibitory)

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor inverse agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000069696
- Version: 101_38
Alternate Names:

DRD4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P21917
- Version: 01-August-2011
Alternate Names:

1815 Entrez Gene Id

P21917 Uniprot Accession

DRD4 Gene Symbol

Gene Info:

Transmembrane Helix Count 7

Target Subclass GPCR

Target Main Class Receptors

Publications:
TdgClinicalTrial: P21917
- Version: January-2014
Alternate Names:

DRD4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: P21917
- Version: 11-September-2012
Alternate Names:

1815 Entrez Gene Id

DRD4 Uniprot Gene Name

ENSG00000069696 Ensembl Gene Id

Gene Info:

Interpro Type Family

Human Readable Name G PROTEIN COUPLED RECEPTOR

Human Readable Name DRUGGABLE GENOME

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000069696
- Version: 26-July-2011
Alternate Names:

NP_000788.2 Display Id

ENSG00000069696 Ensembl Gene Id

DOPAMINE RECEPTOR D4 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_000788] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: DRD4
- Version: chembl_23
Alternate Names:

DRD4 GENE_SYMBOL

D(4) dopamine receptor UNIPROT

D(2C) dopamine receptor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000069696
- Version: 31-May-2017
Alternate Names:

ENSG00000069696 Gene Symbol

DRD4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: DRD4
- Version: 27-Jun-2013
Alternate Names:

1815 Gene ID

D4DR dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Dopamine D4 receptor
- Version: 2020.06.01
Alternate Names:

D4R TTD Gene Abbreviation

T24983 TTD Target ID

Gene Info:

Publications:

Trial Name	intranasal apomorphine
Trial Name	inhaled apomorphine hydrochloride, VR004, VR-040, VR-400
Trial Name	apomorphine hydrochloride,Apokyn, APO-go

Direct Interaction	yes
Mechanism of Interaction	D2-like dopamine receptor agonist
Trial Name	Neupro

Trial Name	dexpramipexole, KNS-760704
Novel drug target	Established target

Mechanism of Interaction	D2-like dopamine receptor inverse agonist
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Dopamine D4 receptor agonist

Mechanism of Interaction	D2-like dopamine receptor antagonist
Direct Interaction	yes

Mechanism of Interaction	Dopamine receptor agonist
Direct Interaction	yes

Trial Name	pardoprunox, SLV 308
Novel drug target	Established target

Trial Name	V-1512, CHF-1512,Levomet Complex, Sirio
Novel drug target	Established target

Direct Interaction	yes
Mechanism of Interaction	Dopamine receptor antagonist

Trial Name	entacapone/levodopa/carbidopa,Stalevo
Novel drug target	Established target
Trial Name	levodopa + carbidopa,Duodopa

1815	Entrez Gene Id
DRD4	Uniprot Gene Name
ENSG00000069696	Ensembl Gene Id

NP_000788.2	Display Id
ENSG00000069696	Ensembl Gene Id
DOPAMINE RECEPTOR D4 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_000788]	Description

DRD4	GENE_SYMBOL
D(4) dopamine receptor	UNIPROT
D(2C) dopamine receptor	UNIPROT

DRD4 Gene Record

DRD4 1815 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Mirapex Novel drug target Established target

PMIDs: 18691132 11752352 9638397 7664822 9617505

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name JZP-7 Novel drug target Established target

PMIDs: 18691132 11752352 19557097

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name intranasal apomorphine Trial Name inhaled apomorphine hydrochloride, VR004, VR-040, VR-400 Trial Name apomorphine hydrochloride,Apokyn, APO-go

PMIDs: 15007532 9871530 9497025 17067298 11752352 17164075 18691132 15037665

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction D2-like dopamine receptor agonist Trial Name Neupro

PMIDs: 18691132

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction D2-like dopamine receptor agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name dexpramipexole, KNS-760704 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction D2-like dopamine receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inverse agonist (inhibitory)

Interaction Info: Mechanism of Interaction D2-like dopamine receptor inverse agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction D2-like dopamine receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Dopamine D4 receptor agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name LU-31130

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inverse agonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction D2-like dopamine receptor inverse agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 17016423 17139284 17848919

Sources: TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target

PMIDs: 18308814 10592235 21655346

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction D2-like dopamine receptor antagonist Direct Interaction yes

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Mirapex

Novel drug target Established target

PMIDs:
18691132 11752352 9638397 7664822 9617505

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name JZP-7

Novel drug target Established target

PMIDs:
18691132 11752352 19557097

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name intranasal apomorphine

Trial Name inhaled apomorphine hydrochloride, VR004, VR-040, VR-400

Trial Name apomorphine hydrochloride,Apokyn, APO-go

PMIDs:
15007532 9871530 9497025 17067298 11752352 17164075 18691132 15037665

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction D2-like dopamine receptor agonist

Trial Name Neupro

PMIDs:
18691132

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction D2-like dopamine receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name dexpramipexole, KNS-760704

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inverse agonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor inverse agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Dopamine D4 receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name LU-31130

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inverse agonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction D2-like dopamine receptor inverse agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
17016423 17139284 17848919

Sources:
TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 10592235 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction D2-like dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name etilevodopa, TV-1203