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EDNRA 1909 Druggable Genome
Alternate Names:
1909 ENDOTHELIN RECEPTOR TYPE A EDNRA ET-A ETA ETA-R ETAR ETRA MFDA hET-AR 131243 3179 ENSG00000151617 OTTHUMG00000161354 ENDOTHELIN-1 RECEPTOR ENDOTHELIN A RECEPTOR P25101 EDNRA_HUMAN ENDOTHELIN-1 RECEPTOR PRECURSOR (ENDOTHELIN A RECEPTOR) (ET-A) (HET- AR) (ETA-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P25101] T23499 Gene Info:
Interpro Type Family Human Readable Name DRUGGABLE GENOME Interpro Short Name 7TM_GPCR_Rhodpsn Human Readable Name G PROTEIN COUPLED RECEPTOR Uniprot Status Swiss-Prot Interpro Acc IPR000276 Interpro Name GPCR, rhodopsin-like, 7TM Uniprot Evidence 1: Evidence at protein level Target Subclass GPCR Target Subclass Rhodopsin Transmembrane Helix Count 7 Target Main Class Receptors Target Class Receptors Gene Biotype PROTEIN_CODING Gene Categories: Category Details
G PROTEIN COUPLED RECEPTOR DRUGGABLE GENOME Publications:
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Interaction Score: 30.91
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Interaction Score: 15.46
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Trial Name clazosentan, AXV-343434,Pivlaz Novel drug target Established target Mechanism of Interaction Endothelin receptor ET-A antagonist -
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Endothelin receptor ET-A antagonist Trial Name YM-598 -
Interaction Score: 11.59
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Endothelin receptor ET-A antagonist Direct Interaction yes Notes -
Interaction Score: 11.59
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Endothelin receptor, ET-A/ET-B antagonist Trial Name macitentan , ACT-064992 -
Interaction Score: 10.3
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Endothelin receptor, ET-A/ET-B antagonist Direct Interaction yes Trial Name Letairis -
Interaction Score: 9.66
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Endothelin receptor ET-A antagonist Trial Name darusentan -
Interaction Score: 9.66
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Novel drug target Established target Trial Name atrasentan, ABT-627,Xinlay -
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Endothelin receptor, ET-A/ET-B antagonist Direct Interaction yes Trial Name Tracleer
Sources:
TdgClinicalTrial ChemblInteractions TEND TTD -
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Endothelin receptor ET-A antagonist Direct Interaction yes Trial Name avosentan, SPP 301 -
Interaction Score: 3.86
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Endothelin receptor ET-A antagonist Direct Interaction yes -
Interaction Score: 3.86
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Endothelin receptor ET-A antagonist Direct Interaction yes -
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
-
Interaction Score: 3.86
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Endothelin receptor ET-A antagonist Direct Interaction yes -
Interaction Score: 3.86
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Endothelin receptor ET-A antagonist -
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name SPI-1620 Novel drug target Established target
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- Version: 101_38
Alternate Names:
EDNRA Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 11-September-2012
Alternate Names:
1909 Entrez Gene Id P25101 Uniprot Accession EDNRA_HUMAN Uniprot Id Gene Info:
Interpro Type Family Human Readable Name DRUGGABLE GENOME Interpro Short Name 7TM_GPCR_Rhodpsn Gene Categories:
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME Publications:
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Alternate Names:
EDNRA Gene Symbol EDNRA_HUMAN Uniprot Id ENSG00000151617 Ensembl Gene Id Gene Info:
Target Subclass GPCR Target Subclass Rhodopsin Transmembrane Helix Count 7 Publications:
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- Version: January-2014
Alternate Names:
EDNRA Gene Symbol Gene Info:
Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin Publications:
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- Version: 26-July-2011
Alternate Names:
EDNRA Display Id ENDOTHELIN-1 RECEPTOR PRECURSOR (ENDOTHELIN A RECEPTOR) (ET-A) (HET- AR) (ETA-R). [SOURCE:UNIPROT/SWISSPROT;ACC:P25101] Description ENSG00000151617 Ensembl Gene Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 2020.06.01
Alternate Names:
EDNRA TTD Gene Abbreviation T23499 TTD Target ID Gene Info:
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Alternate Names:
ETAR Gene Symbol Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000151617 Gene Symbol EDNRA Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: chembl_23
Alternate Names:
ETRA GENE_SYMBOL EDNRA GENE_SYMBOL Endothelin-1 receptor UNIPROT Gene Info:
Publications:
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Alternate Names:
1909 Gene ID ET-A dGene Synonym ETA dGene Synonym Gene Info:
Gene Categories:
G PROTEIN COUPLED RECEPTOR Publications:
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- Version: 30-February-2014
Alternate Names:
Gene Info:
Publications: