EGLN2 Gene Record

  • EGLN2 112398 Druggable Genome

    Alternate Names:

    112398
    EGL-9 FAMILY HYPOXIA INDUCIBLE FACTOR 2
    EGLN2
    EIT6
    HIF-PH1
    HIFPH1
    HPH-1
    HPH-3
    PHD1
    606424
    14660
    ENSG00000269858
    OTTHUMG00000182703
    HIF-prolyl hydroxylase 1
    Prolyl hydroxylase domain-containing protein 1
    Hypoxia-inducible factor prolyl hydroxylase 1
    Estrogen-induced tag 6
    Egl nine homolog 2
    Q96KS0
    T53904
    EIT-6

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:1.14.11.29
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

  • ROXADUSTAT   EGLN2

    Interaction Score: 15.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction HIF-prolyl hydroxylase inhibitor
    Trial Name FG-4592 , ASP1517

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • VADADUSTAT   EGLN2

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AKB-6548
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • DAPRODUSTAT   EGLN2

    Interaction Score: 10.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction HIF-prolyl hydroxylase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • Ensembl: ENSG00000269858

    • Version: 101_38

    Alternate Names:
    EGLN2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q96KS0

    • Version: January-2014

    Alternate Names:
    EGLN2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.14.11.29

    Publications:

  • HingoraniCasas: ENSG00000269858

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000269858 Gene Symbol
    EGLN2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: EIT6

    • Version: chembl_23

    Alternate Names:
    EIT6 GENE_SYMBOL
    EGLN2 GENE_SYMBOL
    Egl nine homolog 2 UNIPROT

    Gene Info:

    Publications:

  • TTD: HIF-prolyl hydroxylase 1

    • Version: 2020.06.01

    Alternate Names:
    HPH-1 TTD Gene Abbreviation
    T53904 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: EGLN2

    • Version: 01-February-2022

    Alternate Names:
    Egl nine homolog 2 Gene Name
    Q96KS0 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications: