EPHB4 Gene Record

  • EPHB4 2050 Druggable GenomeClinically Actionable

    Alternate Names:

    2050
    EPH RECEPTOR B4
    EPHB4
    HFASD
    HTK
    MYK1
    TYRO11
    600011
    3395
    ENSG00000196411
    OTTHUMG00000157040
    P54760
    Ephrin type-B receptor 4
    Hepatoma transmembrane kinase
    Tyrosine-protein kinase TYRO11
    EPHB4_HUMAN
    EPHRIN TYPE-B RECEPTOR 4 PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR HTK). [SOURCE:UNIPROT/SWISSPROT;ACC:P54760]
    T49507
    CMAVM2
    LMPHM7

    Gene Info:

    Target Class Receptors
    Target Subclass EC:2.7.10.1
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001245
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Human Readable Name KINASE
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    KINASE
    TYROSINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

  • TESEVATINIB   EPHB4

    Interaction Score: 11.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Ephrin type-B receptor 4 inhibitor
    Trial Name XL647

    PMIDs:
    None found


    Sources:
    TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

  • JI-101   EPHB4

    Interaction Score: 5.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Ephrin type-B receptor 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TG100-801   EPHB4

    Interaction Score: 0.97

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Ephrin type-B receptor 4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VANDETANIB   EPHB4

    Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Ephrin receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000196411

    • Version: 101_38

    Alternate Names:
    EPHB4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P54760

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000196411 Ensembl Gene Id
    P54760 Uniprot Accession
    EPHB4 Uniprot Gene Name

    Gene Info:
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001245

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P54760

    • Version: January-2014

    Alternate Names:
    EPHB4 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass EC:2.7.10.1

    Publications:

  • RussLampel: ENSG00000196411

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000196411 Ensembl Gene Id
    EPHRIN TYPE-B RECEPTOR 4 PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE RECEPTOR HTK). [SOURCE:UNIPROT/SWISSPROT;ACC:P54760] Description
    EPHB4 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • MyCancerGenome: EPHB4

    • Version: 20-Jun-2017

    Alternate Names:
    2050 Entrez Gene Id
    EPHB4 MyCancerGenome Gene Symbol
    EphB4 MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • TALC: EPHB4

    • Version: 12-May-2016

    Alternate Names:
    EPHB4 Gene Symbol

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000196411

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000196411 Gene Symbol
    EPHB4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: HTK

    • Version: chembl_23

    Alternate Names:
    MYK1 GENE_SYMBOL
    TYRO11 GENE_SYMBOL
    EPHB4 GENE_SYMBOL

    Gene Info:

    Publications:

  • HumanProteinAtlas: EPHB4

    • Version: 19.3

    Alternate Names:
    ENSG00000196411 Ensembl Gene ID
    HTK Human Protein Atlas Gene Synonym
    Tyro11 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • dGene: EPHB4

    • Version: 27-Jun-2013

    Alternate Names:
    2050 Gene ID
    HTK dGene Synonym
    MYK1 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, TYROSINE KINASE

    Publications:

  • TTD: Ephrin type-B receptor 4

    • Version: 2020.06.01

    Alternate Names:
    EPHB4 TTD Gene Abbreviation
    T49507 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: EPHB4

    • Version: 01-February-2022

    Alternate Names:
    Ephrin type-B receptor 4 Gene Name
    P54760 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • FoundationOneGenes: EPHB4

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: