DGIdb - ETV6 Gene Record

ETV6 2120 Clinically Actionable

Alternate Names:

2120
ETS VARIANT 6
ETV6
TEL
TEL/ABL
THC5
600618
3495
ENSG00000139083
OTTHUMG00000168538
ETS VARIANT TRANSCRIPTION FACTOR 6
Transcription factor ETV6
P41212

Gene Info:

Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Jin et al., 2005, The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta type II receptor., Proc. Natl. Acad. Sci. U.S.A.
Taipale et al., 2013, Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells., Nat. Biotechnol.
Tognon et al., 2011, ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway., Cancer Res.
Nagasubramanian et al., 2016, Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101., Pediatr Blood Cancer
Drilon et al., 2017, A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors., Cancer Discov
Doebele et al., 2015, An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101., Cancer Discov
Drilon et al., 2016, What hides behind the MASC: clinical response and acquired resistance to entrectinib after ETV6-NTRK3 identification in a mammary analogue secretory carcinoma (MASC)., Ann. Oncol.
Ardini et al., 2016, Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor with Activity in Multiple Molecularly Defined Cancer Indications., Mol. Cancer Ther.
Tognon et al., 2012, A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation., Oncogene
Curtis et al., 2007, Two novel imatinib-responsive PDGFRA fusion genes in chronic eosinophilic leukaemia., Br. J. Haematol.
Majsterek et al., 2003, TEL-fusion oncogenic tyrosine kinases determine leukemic cells response to idarubicin., Anticancer Drugs
Chi et al., 2012, ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412., Biochem. Biophys. Res. Commun.
Stams et al., 2005, Expression levels of TEL, AML1, and the fusion products TEL-AML1 and AML1-TEL versus drug sensitivity and clinical outcome in t(12;21)-positive pediatric acute lymphoblastic leukemia., Clin. Cancer Res.

CHEMBL401930 ETV6

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Preclinical

PMIDs:
21804605

Sources:
JAX-CKB
LAROTRECTINIB ETV6

Interaction Score: 5.15

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type acute myeloid leukemia

Response Type sensitive

Approval Status Preclinical

PMIDs:
27093299 28578312 26216294

Sources:
JAX-CKB
HMPL-523 ETV6

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Preclinical - Cell culture

PMIDs:
None found

Sources:
JAX-CKB
LESTAURTINIB ETV6

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
16258068

Sources:
JAX-CKB
BMS-754807 ETV6

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
21148487

Sources:
JAX-CKB
ASPARAGINASE ETV6

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15837750

Sources:
NCI
ALTIRATINIB ETV6

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Preclinical

PMIDs:
None found

Sources:
JAX-CKB
CRIZOTINIB ETV6

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical - Cell line xenograft

Response Type sensitive

PMIDs:
23811600

Sources:
JAX-CKB
MIDOSTAURIN ETV6

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
23131561

Sources:
JAX-CKB
IDARUBICIN ETV6

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14501384

Sources:
NCI
ENTRECTINIB ETV6

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

Approval Status Preclinical - Cell culture

Approval Status Phase I

Indication/Tumor Type salivary gland cancer

PMIDs:
26884591 26939704

Sources:
JAX-CKB
IMATINIB ETV6

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type chronic leukemia

Response Type sensitive

Approval Status Clinical Study

PMIDs:
17555450

Sources:
JAX-CKB

Ensembl: ENSG00000139083
- Version: 101_38
Alternate Names:

ETV6 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

JAX-CKB: ETV6

Version: 27-September-2017

Alternate Names:

2120 CKB Entrez Id

ETV6 CKB Gene Synonym

TEL CKB Gene Synonym

Gene Info:

Publications:

Jin et al., 2005, The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta type II receptor., Proc. Natl. Acad. Sci. U.S.A.

Curtis et al., 2007, Two novel imatinib-responsive PDGFRA fusion genes in chronic eosinophilic leukaemia., Br. J. Haematol.

Jin et al., 2016, Determination of ETV6-RUNX1 genomic breakpoint by next-generation sequencing., Cancer Med

NCI: ETV6

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Majsterek et al., 2003, TEL-fusion oncogenic tyrosine kinases determine leukemic cells response to idarubicin., Anticancer Drugs

Stams et al., 2005, Expression levels of TEL, AML1, and the fusion products TEL-AML1 and AML1-TEL versus drug sensitivity and clinical outcome in t(12;21)-positive pediatric acute lymphoblastic leukemia., Clin. Cancer Res.

Tempus: ETV6
- Version: 11-November-2018
Alternate Names:

ETV6 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: ETV6
- Version: 01-February-2022
Alternate Names:

Transcription factor ETV6 Gene Name

P41212 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
MskImpact: ETV6
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: ETV6
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: ETV6
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Indication/Tumor Type	Advanced Solid Tumor
Response Type	sensitive
Approval Status	Preclinical

Indication/Tumor Type	acute myeloid leukemia
Response Type	sensitive
Approval Status	Preclinical

Evidence Type	Actionable
Approval Status	Preclinical
Response Type	sensitive

Indication/Tumor Type	cancer
Response Type	sensitive
Approval Status	Preclinical

Approval Status	Preclinical - Cell culture
Approval Status	Phase I
Indication/Tumor Type	salivary gland cancer

Indication/Tumor Type	chronic leukemia
Response Type	sensitive
Approval Status	Clinical Study

ETV6 Gene Record

ETV6 2120 Clinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type Advanced Solid Tumor Response Type sensitive Approval Status Preclinical

PMIDs: 21804605

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type acute myeloid leukemia Response Type sensitive Approval Status Preclinical

PMIDs: 27093299 28578312 26216294

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type Advanced Solid Tumor Response Type sensitive Approval Status Preclinical - Cell culture

PMIDs: None found

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Evidence Type Actionable Approval Status Preclinical Response Type sensitive

PMIDs: 16258068

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Evidence Type Actionable Approval Status Preclinical Response Type sensitive

PMIDs: 21148487

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15837750

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type Advanced Solid Tumor Response Type sensitive Approval Status Preclinical

PMIDs: None found

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Evidence Type Actionable Approval Status Preclinical - Cell line xenograft Response Type sensitive

PMIDs: 23811600

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type cancer Response Type sensitive Approval Status Preclinical

PMIDs: 23131561

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14501384

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Approval Status Preclinical - Cell culture Approval Status Phase I Indication/Tumor Type salivary gland cancer

PMIDs: 26884591 26939704

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type chronic leukemia Response Type sensitive Approval Status Clinical Study

PMIDs: 17555450

Sources: JAX-CKB

Ensembl: ENSG00000139083

Alternate Names: ETV6 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

JAX-CKB: ETV6

Alternate Names: 2120 CKB Entrez Id ETV6 CKB Gene Synonym TEL CKB Gene Synonym

Gene Info:

NCI: ETV6

Alternate Names:

Gene Info:

Tempus: ETV6

Alternate Names: ETV6 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Pharos: ETV6

Alternate Names: Transcription factor ETV6 Gene Name P41212 UniProt ID

Gene Info:

Gene Categories: TRANSCRIPTION FACTOR

Publications:

MskImpact: ETV6

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

FoundationOneGenes: ETV6

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Preclinical

PMIDs:
21804605

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type acute myeloid leukemia

Response Type sensitive

Approval Status Preclinical

PMIDs:
27093299 28578312 26216294

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Preclinical - Cell culture

PMIDs:
None found

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
16258068

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
21148487

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
15837750

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type Advanced Solid Tumor

Response Type sensitive

Approval Status Preclinical

PMIDs:
None found

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical - Cell line xenograft

Response Type sensitive

PMIDs:
23811600

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
23131561

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
14501384

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Approval Status Preclinical - Cell culture

Approval Status Phase I

Indication/Tumor Type salivary gland cancer

PMIDs:
26884591 26939704

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type chronic leukemia

Response Type sensitive

Approval Status Clinical Study

PMIDs:
17555450

Sources:
JAX-CKB

Alternate Names:

ETV6 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

2120 CKB Entrez Id

ETV6 CKB Gene Synonym

TEL CKB Gene Synonym

Alternate Names:

ETV6 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

Transcription factor ETV6 Gene Name

P41212 UniProt ID

Gene Categories:

TRANSCRIPTION FACTOR

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE