DGIdb - F8 Gene Record

F8 2157 Druggable Genome

Alternate Names:

2157
COAGULATION FACTOR VIII
F8
AHF
DXS1253E
F8B
F8C
FVIII
HEMA
300841
3546
ENSG00000185010
OTTHUMG00000022688
Factor VIII B chain
Factor VIIIa light chain
Antihemophilic factor
Procoagulant component
Factor VIIIa heavy chain, 92 kDa isoform
Factor VIIIa heavy chain, 200 kDa isoform
P00451
FA8_HUMAN
T14602

Gene Info:

Target Class	Miscellaneous
Target Subclass	Enzyme cofactor
Target Main Class	Other
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Chen et al., 1996, Expression of glutamyl-tRNA reductase in Escherichia coli., Biochim. Biophys. Acta
Hu et al., 1990, [A new therapy of hemophilia with ranitidine]., Zhonghua Nei Ke Za Zhi

TB-402 F8

Interaction Score: 30.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Coagulation factor VIII inhibitor

Trial Name TB-402

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
EFMOROCTOCOG ALFA F8

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SORBITOL F8

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8950186

Sources:
NCI
DROTRECOGIN ALFA (ACTIVATED) F8

Interaction Score: 5.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Coagulation factor VIII inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RANITIDINE F8

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2120016

Sources:
NCI
THROMBIN F8

Interaction Score: 0.43

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Novel drug target Established target

Trial Name ProFibrix B.V/

PMIDs:
None found

Sources:
TdgClinicalTrial

Ensembl: ENSG00000185010
- Version: 101_38
Alternate Names:

F8 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P00451
- Version: 01-August-2011
Alternate Names:

F8 Gene Symbol

P00451 Uniprot Accession

FA8_HUMAN Uniprot Id

Gene Info:

Target Subclass Enzyme cofactor

Target Main Class Other

Publications:
TdgClinicalTrial: P00451
- Version: January-2014
Alternate Names:

F8 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Enzyme cofactor

Publications:
TTD: Coagulation factor VIII
- Version: 2020.06.01
Alternate Names:

F8 TTD Gene Abbreviation

T14602 TTD Target ID

Gene Info:

Publications:

2009, 6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates., Transfus Med Hemother

NCI: F8

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Chen et al., 1996, Expression of glutamyl-tRNA reductase in Escherichia coli., Biochim. Biophys. Acta

Blaudschun et al., 2002, Vascular endothelial growth factor causally contributes to the angiogenic response upon ultraviolet B irradiation in vivo., Br. J. Dermatol.

Oka, The possibility of improving biocompatibility by removing anaphylatoxins from the circuit of blood-perfused artificial organs., ASAIO Trans

HingoraniCasas: ENSG00000185010
- Version: 31-May-2017
Alternate Names:

ENSG00000185010 Gene Symbol

F8 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: F8C
- Version: chembl_23
Alternate Names:

F8C GENE_SYMBOL

F8 GENE_SYMBOL

Coagulation factor VIII UNIPROT

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Coagulation factor VIII inhibitor
Trial Name	TB-402

Novel drug target	Established target
Trial Name	ProFibrix B.V/

F8	Gene Symbol
P00451	Uniprot Accession
FA8_HUMAN	Uniprot Id

F8	TTD Gene Abbreviation
T14602	TTD Target ID

ENSG00000185010	Gene Symbol
F8	Ensembl Id

F8 Gene Record

F8 2157 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

TB-402 F8

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Coagulation factor VIII inhibitor Trial Name TB-402

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

EFMOROCTOCOG ALFA F8

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

SORBITOL F8

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8950186

Sources: NCI

DROTRECOGIN ALFA (ACTIVATED) F8

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Coagulation factor VIII inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

RANITIDINE F8

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2120016

Sources: NCI

THROMBIN F8

Interaction Types & Directionality: activator (activating)

Interaction Info: Novel drug target Established target Trial Name ProFibrix B.V/

PMIDs: None found

Sources: TdgClinicalTrial

Ensembl: ENSG00000185010

Alternate Names: F8 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P00451

Alternate Names: F8 Gene Symbol P00451 Uniprot Accession FA8_HUMAN Uniprot Id

Gene Info: Target Subclass Enzyme cofactor Target Main Class Other

Publications:

TdgClinicalTrial: P00451

Alternate Names: F8 Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Enzyme cofactor

Publications:

TTD: Coagulation factor VIII

Alternate Names: F8 TTD Gene Abbreviation T14602 TTD Target ID

Gene Info:

Publications: 2009, 6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates., Transfus Med Hemother

NCI: F8

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000185010

Alternate Names: ENSG00000185010 Gene Symbol F8 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: F8C

Alternate Names: F8C GENE_SYMBOL F8 GENE_SYMBOL Coagulation factor VIII UNIPROT

Gene Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Coagulation factor VIII inhibitor

Trial Name TB-402

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
8950186

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Coagulation factor VIII inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
2120016

Sources:
NCI

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Novel drug target Established target

Trial Name ProFibrix B.V/

PMIDs:
None found

Sources:
TdgClinicalTrial

Alternate Names:

F8 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

F8 Gene Symbol

P00451 Uniprot Accession

FA8_HUMAN Uniprot Id

Gene Info:

Target Subclass Enzyme cofactor

Target Main Class Other

Alternate Names:

F8 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Enzyme cofactor

Alternate Names:

F8 TTD Gene Abbreviation

T14602 TTD Target ID

Publications:

2009, 6 Factor VIII Concentrates, Factor VIII/von Willebrand Factor Concentrates, Factor IX Concentrates, Activated Prothrombin Complex Concentrates., Transfus Med Hemother

Alternate Names:

ENSG00000185010 Gene Symbol

F8 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

F8C GENE_SYMBOL

F8 GENE_SYMBOL

Coagulation factor VIII UNIPROT