DGIdb - FDFT1 Gene Record

FDFT1 2222 Druggable Genome

Alternate Names:

2222
FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE 1
FDFT1
DGPT
ERG9
SQS
SS
184420
3629
ENSG00000079459
OTTHUMG00000090801
Farnesyl-diphosphate farnesyltransferase
FPP:FPP farnesyltransferase
Squalene synthase
P37268
FDFT_HUMAN
FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE (EC 2.5.1.21) (SQUALENE SYNTHETASE) (SQS) (SS) (FPP:FPP FARNESYLTRANSFERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P37268]
SQSD

Gene Info:

Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Short Name	Squ/phyt_synthse
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR002060
Interpro Name	Squalene/phytoene synthase
Interpro Type	Family
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Jiang et al., 1993, Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase., J. Biol. Chem.

LAPAQUISTAT ACETATE FDFT1

Interaction Score: 30.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Squalene synthetase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LOVASTATIN FDFT1

Interaction Score: 1.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7685352

Sources:
NCI

Ensembl: ENSG00000079459
- Version: 101_38
Alternate Names:

FDFT1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P37268
- Version: 11-September-2012
Alternate Names:

ENSG00000079459 Ensembl Gene Id

P37268 Uniprot Accession

SQUALENE SYNTHASE Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Interpro Short Name Squ/phyt_synthse

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000079459

Version: 26-July-2011

Alternate Names:

ENSG00000079459 Ensembl Gene Id

FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE (EC 2.5.1.21) (SQUALENE SYNTHETASE) (SQS) (SS) (FPP:FPP FARNESYLTRANSFERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P37268] Description

FDFT1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: FDFT1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Jiang et al., 1993, Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase., J. Biol. Chem.

HingoraniCasas: ENSG00000079459
- Version: 31-May-2017
Alternate Names:

ENSG00000079459 Gene Symbol

FDFT1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: FDFT1
- Version: chembl_23
Alternate Names:

FDFT1 GENE_SYMBOL

Squalene synthase UNIPROT

FPP:FPP farnesyltransferase UNIPROT

Gene Info:

Publications:
Pharos: FDFT1
- Version: 01-February-2022
Alternate Names:

Squalene synthase Gene Name

P37268 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Mechanism of Interaction	Squalene synthetase inhibitor
Direct Interaction	yes

ENSG00000079459	Ensembl Gene Id
P37268	Uniprot Accession
SQUALENE SYNTHASE	Uniprot Protein Name

FDFT1	GENE_SYMBOL
Squalene synthase	UNIPROT
FPP:FPP farnesyltransferase	UNIPROT

FDFT1 Gene Record

FDFT1 2222 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

LAPAQUISTAT ACETATE FDFT1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Squalene synthetase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

LOVASTATIN FDFT1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7685352

Sources: NCI

Ensembl: ENSG00000079459

Alternate Names: FDFT1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P37268

Alternate Names: ENSG00000079459 Ensembl Gene Id P37268 Uniprot Accession SQUALENE SYNTHASE Uniprot Protein Name

Gene Info: Uniprot Evidence 1: Evidence at protein level Uniprot Status Swiss-Prot Interpro Short Name Squ/phyt_synthse

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000079459

Alternate Names: ENSG00000079459 Ensembl Gene Id FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE (EC 2.5.1.21) (SQUALENE SYNTHETASE) (SQS) (SS) (FPP:FPP FARNESYLTRANSFERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P37268] Description FDFT1 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

NCI: FDFT1

Alternate Names:

Gene Info:

Publications: Jiang et al., 1993, Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase., J. Biol. Chem.

HingoraniCasas: ENSG00000079459

Alternate Names: ENSG00000079459 Gene Symbol FDFT1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: FDFT1

Alternate Names: FDFT1 GENE_SYMBOL Squalene synthase UNIPROT FPP:FPP farnesyltransferase UNIPROT

Gene Info:

Publications:

Pharos: FDFT1

Alternate Names: Squalene synthase Gene Name P37268 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Squalene synthetase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
7685352

Sources:
NCI

Alternate Names:

FDFT1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000079459 Ensembl Gene Id

P37268 Uniprot Accession

SQUALENE SYNTHASE Uniprot Protein Name

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Interpro Short Name Squ/phyt_synthse

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000079459 Ensembl Gene Id

FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE (EC 2.5.1.21) (SQUALENE SYNTHETASE) (SQS) (SS) (FPP:FPP FARNESYLTRANSFERASE). [SOURCE:UNIPROT/SWISSPROT;ACC:P37268] Description

FDFT1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

Jiang et al., 1993, Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase., J. Biol. Chem.

Alternate Names:

ENSG00000079459 Gene Symbol

FDFT1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

FDFT1 GENE_SYMBOL

Squalene synthase UNIPROT

FPP:FPP farnesyltransferase UNIPROT

Alternate Names:

Squalene synthase Gene Name

P37268 UniProt ID

Gene Categories:

ENZYME