2224 |
FARNESYL DIPHOSPHATE SYNTHASE |
FDPS |
FPPS |
FPS |
POROK9 |
134629 |
3631 |
ENSG00000160752 |
OTTHUMG00000013909 |
P14324 |
FPP synthase |
Geranyltranstransferase |
Dimethylallyltranstransferase |
(2E,6E)-farnesyl diphosphate synthase |
Farnesyl pyrophosphate synthase |
KIAA1293 |
PA28075 |
FPPS_HUMAN |
T86528 |
Target Main Class | Enzymes |
Target Subclass | 2.5.1.- |
Target Class | Enzymes |
Target Subclass | EC:2.5.1.10 |
Target Subclass | EC:2.5.1.- |
Gene Biotype | PROTEIN_CODING |
DRUGGABLE GENOME |
ENZYME |
inhibitor (inhibitory) |
Trial Name | risedronate sodium, NE-58095,Actonel, Benet, Atelvia |
Novel drug target | Established target |
Trial Name | - |
inhibitor (inhibitory) |
Mechanism of Interaction | Farnesyl diphosphate synthase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Farnesyl diphosphate synthase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Farnesyl diphosphate synthase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Farnesyl diphosphate synthase inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Farnesyl diphosphate synthase inhibitor |
Direct Interaction | yes |
Trial Name | Zoledronic |
inhibitor (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
FDPS | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
FDPS | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.5.1.10 |
Target Subclass | EC:2.5.1.- |
FDPS | Gene Symbol |
P14324 | Uniprot Accession |
ENSG00000160752 | Ensembl Gene Id |
Target Main Class | Enzymes |
Target Subclass | 2.5.1.- |
PA28075 | PharmGKB ID |
ENSG00000160752 | Gene Symbol |
FDPS | Ensembl Id |
DRUGGABLE GENOME |
KIAA1293 | GENE_SYMBOL |
FDPS | GENE_SYMBOL |
Farnesyl pyrophosphate synthase | UNIPROT |
FDPS | Gene Symbol |
CLINICALLY ACTIONABLE |
FDPS | TTD Gene Abbreviation |
T86528 | TTD Target ID |
Farnesyl pyrophosphate synthase | Gene Name |
P14324 | UniProt ID |
ENZYME |