2263 |
FIBROBLAST GROWTH FACTOR RECEPTOR 2 |
FGFR2 |
BBDS |
BEK |
BFR-1 |
CD332 |
CEK3 |
CFD1 |
ECT1 |
JWS |
K-SAM |
KGFR |
TK14 |
TK25 |
176943 |
3689 |
ENSG00000066468 |
OTTHUMG00000019175 |
FGFR-2 |
KSAM |
CD_antigen=CD332 |
Keratinocyte growth factor receptor |
FGFR2_HUMAN |
P21802 |
22 |
FIBROBLAST GROWTH FACTOR RECEPTOR 2 PRECURSOR (EC 2.7.1.112) (FGFR-2) (KERATINOCYTE GROWTH FACTOR RECEPTOR 2). [SOURCE:UNIPROT/SWISSPROT;ACC:P21802] |
FGFR1-3 |
PA28128 |
T58454 |
CancerCommons Reported Gene Name | FGFRs |
Human Readable Name | DRUGGABLE GENOME |
Transmembrane Helix Count | 1 |
Target Main Class | Receptors |
Target Subclass | Kinase |
Target Subclass | FGFR |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
Initial Gene Query | FGFR2 |
Counted Citations from 1950-2000 | 944 |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Human Readable Name | KINASE |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR001245 |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Domain |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
KINASE |
TYROSINE KINASE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
agonist (activating) |
binder |
Trial Name | rHu-KGF, keratinocyte growth factor (KGF),Kepivance |
Novel drug target | Established target |
Mechanism of Interaction | Fibroblast growth factor receptor 2 agonist |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Notes | |
Direct Interaction | yes |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
inhibitor (inhibitory) |
Indication/Tumor Type | breast cancer |
Response Type | predicted – sensitive |
Approval Status | Phase I |
n/a |
Evidence Type | Actionable |
Approval Status | Preclinical - Cell line xenograft |
Response Type | sensitive |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
n/a |
Trial Name | trafermin, fibro/ |
Novel drug target | Established target |
inhibitor (inhibitory) |
Response Type | decreased response |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | sensitive |
inhibitor (inhibitory) |
Trial Name | BIBF-1120,Vargatef |
Novel drug target | Established target |
Notes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | dovitinib, TKI-258, CHIR-258 |
Variant Effect | gain-of-function |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor 2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
n/a |
Trial Name | Muparfostat |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | Thalomid |
Novel drug target | Established target |
n/a |
Trial Name | ENMD-2076 |
Novel drug target | Established target |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor 2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor 2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Fibroblast growth factor receptor 2 inhibitor |
Direct Interaction | yes |
FGFR2 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
FGFR2 | Display Id |
ENSG00000066468 | Ensembl Gene Id |
FIBROBLAST GROWTH FACTOR RECEPTOR 2 PRECURSOR (EC 2.7.1.112) (FGFR-2) (KERATINOCYTE GROWTH FACTOR RECEPTOR 2). [SOURCE:UNIPROT/SWISSPROT;ACC:P21802] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ENSG00000066468 | Ensembl Gene Id |
FGFR2 | Uniprot Gene Name |
P21802 | Uniprot Accession |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Human Readable Name | KINASE |
Uniprot Status | Swiss-Prot |
KINASE, DRUGGABLE GENOME |
ENSG00000066468 | Ensembl Gene Id |
P21802 | Uniprot Accession |
2263 | Entrez Gene Id |
Transmembrane Helix Count | 1 |
Target Main Class | Receptors |
Target Subclass | Kinase |
2263 | Entrez Gene ID |
CancerCommons Reported Gene Name | FGFRs |
FGFR2 | Gene Symbol |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
2263 | Entrez Gene ID |
Initial Gene Query | FGFR2 |
Counted Citations from 1950-2000 | 944 |
KINASE |
2263 | CKB Entrez Id |
FGFR2 | CKB Gene Synonym |
BBDS | CKB Gene Synonym |
PA28128 | PharmGKB ID |
2263 | Entrez Gene ID |
22 | CIViC Gene ID |
CLINICALLY ACTIONABLE |
FGFR2 | Gene Symbol |
2263 | Entrez Gene Id |
FGFR2 | MyCancerGenome Gene Symbol |
FGFR1-3 | MyCancerGenome Reported Gene Name |
ENSG00000066468 | Gene Symbol |
FGFR2 | Ensembl Id |
DRUGGABLE GENOME |
FGFR-2 | Gene Symbol |
KGFR | GENE_SYMBOL |
KSAM | GENE_SYMBOL |
FGFR2 | GENE_SYMBOL |
2263 | OncoKB Entrez Id |
BBDS | OncoKB Gene Synonym |
BFR-1 | OncoKB Gene Synonym |
BEK | GO Gene Synonym |
KGFR | GO Gene Synonym |
KSAM | GO Gene Synonym |
CELL SURFACE, TYROSINE KINASE |
FGFR2 | Gene Symbol |
CLINICALLY ACTIONABLE |
2263 | Gene ID |
BBDS | dGene Synonym |
BEK | dGene Synonym |
KINASE, TYROSINE KINASE |
FGFR2 | TTD Gene Abbreviation |
T58454 | TTD Target ID |
Fibroblast growth factor receptor 2 | Gene Name |
P21802 | UniProt ID |
KINASE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |