DGIdb - FGFR4 Gene Record

FGFR4 2264 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

2264
FIBROBLAST GROWTH FACTOR RECEPTOR 4
FGFR4
CD334
JTK2
TKF
134935
3691
ENSG00000160867
OTTHUMG00000151523
P22455
FGFR4_HUMAN
FGFR-4
CD_antigen=CD334
FIBROBLAST GROWTH FACTOR RECEPTOR 4 PRECURSOR (EC 2.7.1.112) (FGFR-4). [SOURCE:UNIPROT/SWISSPROT;ACC:P22455]
1887
PA28130
T90989

Gene Info:

Human Readable Name	KINASE
Interpro Type	Domain
Interpro Acc	IPR001245
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Target Class	Receptors
Target Subclass	EC:2.7.10.1
CancerCommons Reported Gene Name	FGFRs
Target Subclass	FGFR
Transmembrane Helix Count	1
Target Subclass	Kinase
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(17 More Sources)

Gene Categories: Category Details

KINASE
TYROSINE KINASE
DRUG RESISTANCE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Gozgit et al., 2013, Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models., Cancer Chemother. Pharmacol.
Li SQ et al., 2013, Targeting wild-type and mutationally activated FGFR4 in rhabdomyosarcoma with the inhibitor ponatinib (AP24534)., PLoS One
Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
Imagawa et al., 1994, Keratinocyte growth factor and acidic fibroblast growth factor are mitogens for primary cultures of mammary epithelium., Biochem. Biophys. Res. Commun.
Sher et al., 2000, Identification of residues important both for primary receptor binding and specificity in fibroblast growth factor-7., J. Biol. Chem.
Sannes et al., 1998, Sulfation of extracellular matrices modifies growth factor effects on type II cells on laminin substrata., Am. J. Physiol.
Yamanaka et al., 2000, Isolation and serum-free culture of epithelial cells derived from epithelial rests of Malassez in human periodontal ligament., In Vitro Cell. Dev. Biol. Anim.
Luo et al., 1998, The glycine box: a determinant of specificity for fibroblast growth factor., Biochemistry
Thussbas C et al., 2006, FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer., J Clin Oncol
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Quintanal-Villalonga A et al., 2019, FGFR4 increases EGFR oncogenic signaling in lung adenocarcinoma, and their combined inhibition is highly effective., Lung Cancer

PALIFERMIN FGFR4

Interaction Score: 2.77

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name rHu-KGF, keratinocyte growth factor (KGF),Kepivance

Novel drug target Established target

PMIDs:
7526860 10950949 9755102 11149756 9843417

Sources:
TdgClinicalTrial TEND
FGF401 FGFR4

Interaction Score: 2.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BRIVANIB FGFR4

Interaction Score: 0.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

PMIDs:
20124951

Sources:
ChemblInteractions PharmGKB
AZD-4547 FGFR4

Interaction Score: 0.59

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRAFERMIN FGFR4

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name trafermin, fibro/

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
LY-2874455 FGFR4

Interaction Score: 0.59

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DERAZANTINIB FGFR4

Interaction Score: 0.59

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ROGARATINIB FGFR4

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FP-1039 FGFR4

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name FP-1039

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
BRIVANIB ALANINATE FGFR4

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PONATINIB FGFR4

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
23468082 24124571

Sources:
CIViC
CP-459632 FGFR4

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORANTINIB FGFR4

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NINTEDANIB ESYLATE FGFR4

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
XL-999 FGFR4

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INFIGRATINIB FGFR4

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions CancerCommons
NINTEDANIB FGFR4

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial
ERLOTINIB FGFR4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31027687

Sources:
CIViC
ENMD-2076 FGFR4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial
ENMD-981693 FGFR4

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOVITINIB FGFR4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24124571

Sources:
ClearityFoundationClinicalTrial CIViC
EVEROLIMUS FGFR4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CYCLOPHOSPHAMIDE FGFR4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16822847

Sources:
PharmGKB
HESPERADIN FGFR4

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
FLUOROURACIL FGFR4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16822847

Sources:
PharmGKB
METHOTREXATE FGFR4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16822847

Sources:
PharmGKB

Ensembl: ENSG00000160867
- Version: 101_38
Alternate Names:

FGFR4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P22455
- Version: January-2014
Alternate Names:

FGFR4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass EC:2.7.10.1

Publications:
HopkinsGroom: P22455
- Version: 11-September-2012
Alternate Names:

ENSG00000160867 Ensembl Gene Id

FGFR4_HUMAN Uniprot Id

P22455 Uniprot Accession

Gene Info:

Human Readable Name KINASE

Interpro Type Domain

Interpro Acc IPR001245

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
TEND: P22455
- Version: 01-August-2011
Alternate Names:

P22455 Uniprot Accession

FGFR4 Gene Symbol

2264 Entrez Gene Id

Gene Info:

Target Subclass FGFR

Transmembrane Helix Count 1

Target Subclass Kinase

Publications:
CancerCommons: FGFR4
- Version: 25-July-2013
Alternate Names:

2264 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name FGFRs

Publications:
RussLampel: ENSG00000160867
- Version: 26-July-2011
Alternate Names:

FIBROBLAST GROWTH FACTOR RECEPTOR 4 PRECURSOR (EC 2.7.1.112) (FGFR-4). [SOURCE:UNIPROT/SWISSPROT;ACC:P22455] Description

ENSG00000160867 Ensembl Gene Id

FGFR4 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: FGFR4

Version: 18-August-2020

Alternate Names:

PA28130 PharmGKB ID

Gene Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

Thussbas C et al., 2006, FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer., J Clin Oncol

CIViC: FGFR4

Version: 14-September-2020

Alternate Names:

2264 Entrez Gene ID

1887 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Li SQ et al., 2013, Targeting wild-type and mutationally activated FGFR4 in rhabdomyosarcoma with the inhibitor ponatinib (AP24534)., PLoS One

Quintanal-Villalonga A et al., 2019, FGFR4 increases EGFR oncogenic signaling in lung adenocarcinoma, and their combined inhibition is highly effective., Lung Cancer

NCI: FGFR4
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Uehara, 2006, Localization of FGF-6 and FGFR-4 during prenatal and early postnatal development of the mouse sublingual gland., J Oral Sci
DTC: FGFR4
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
HingoraniCasas: ENSG00000160867
- Version: 31-May-2017
Alternate Names:

ENSG00000160867 Gene Symbol

FGFR4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: JTK2
- Version: chembl_23
Alternate Names:

TKF GENE_SYMBOL

FGFR4 GENE_SYMBOL

Fibroblast growth factor receptor 4 UNIPROT

Gene Info:

Publications:
Tempus: FGFR4
- Version: 11-November-2018
Alternate Names:

FGFR4 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: FGFR4
- Version: 27-Jun-2013
Alternate Names:

2264 Gene ID

CD334 dGene Synonym

JTK2 dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
TTD: Fibroblast growth factor receptor 4
- Version: 2020.06.01
Alternate Names:

FGFR4 TTD Gene Abbreviation

T90989 TTD Target ID

Gene Info:

Publications:
Pharos: FGFR4
- Version: 01-February-2022
Alternate Names:

Fibroblast growth factor receptor 4 Gene Name

P22455 UniProt ID

Gene Info:

Gene Categories:

KINASE, ENZYME

Publications:
ClearityFoundationClinicalTrial: FGFR4
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
MskImpact: FGFR4
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: FGFR4
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: FGFR4
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: FGFR4
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Trial Name	rHu-KGF, keratinocyte growth factor (KGF),Kepivance
Novel drug target	Established target

Mechanism of Interaction	Fibroblast growth factor receptor 4 inhibitor
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Fibroblast growth factor receptor inhibitor

Trial Name	trafermin, fibro/
Novel drug target	Established target

Reported Cancer Type	Melanoma
Mechanism of Interaction	Fibroblast growth factor receptor inhibitor
Direct Interaction	yes

ENSG00000160867	Ensembl Gene Id
FGFR4_HUMAN	Uniprot Id
P22455	Uniprot Accession

FIBROBLAST GROWTH FACTOR RECEPTOR 4 PRECURSOR (EC 2.7.1.112) (FGFR-4). [SOURCE:UNIPROT/SWISSPROT;ACC:P22455]	Description
ENSG00000160867	Ensembl Gene Id
FGFR4	Display Id

TKF	GENE_SYMBOL
FGFR4	GENE_SYMBOL
Fibroblast growth factor receptor 4	UNIPROT

Fibroblast growth factor receptor 4	Gene Name
P22455	UniProt ID

FGFR4 Gene Record

FGFR4 2264 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name rHu-KGF, keratinocyte growth factor (KGF),Kepivance Novel drug target Established target

PMIDs: 7526860 10950949 9755102 11149756 9843417

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Fibroblast growth factor receptor 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Fibroblast growth factor receptor inhibitor

PMIDs: 20124951

Sources: ChemblInteractions PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Fibroblast growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name trafermin, fibro/ Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Fibroblast growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Fibroblast growth factor receptor inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Fibroblast growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name FP-1039 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Fibroblast growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 23468082 24124571

Sources: CIViC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Fibroblast growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Fibroblast growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Fibroblast growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Fibroblast growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Melanoma Mechanism of Interaction Fibroblast growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions CancerCommons

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 31027687

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name rHu-KGF, keratinocyte growth factor (KGF),Kepivance

Novel drug target Established target

PMIDs:
7526860 10950949 9755102 11149756 9843417

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

PMIDs:
20124951

Sources:
ChemblInteractions PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name trafermin, fibro/

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name FP-1039

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
23468082 24124571

Sources:
CIViC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Melanoma

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions CancerCommons

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
31027687

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
24124571

Sources:
ClearityFoundationClinicalTrial CIViC

Interaction Types & Directionality:

n/a