2280 |
FK506 BINDING PROTEIN 1A |
FKBP1A |
FKBP-12 |
FKBP-1A |
FKBP1 |
FKBP12 |
PKC12 |
PKCI2 |
PPIASE |
186945 |
3711 |
ENSG00000088832 |
OTTHUMG00000031666 |
P62942 |
Peptidyl-prolyl cis-trans isomerase FKBP1A |
12 kDa FK506-binding protein |
Calstabin-1 |
FK506-binding protein 1A |
Immunophilin FKBP12 |
Rotamase |
PPIase FKBP1A |
12 kDa FKBP |
FKB1A_HUMAN |
FK506-BINDING PROTEIN 1A (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (12 KDA FKBP) (FKBP-12) (IMMUNOPHILIN FKBP12). [SOURCE:UNIPROT/SWISSPROT;ACC:P62942] |
CYCLOPHILIN |
FKBP prolyl isomerase 1A |
T76059 |
PPI |
T07601 |
Target Class | Enzymes |
Target Subclass | EC:5.2.1.8 |
Human Readable Name | DRUGGABLE GENOME |
Interpro Short Name | PPIase_FKBP_dom |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR001179 |
Interpro Type | Domain |
Interpro Name | Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain |
Uniprot Evidence | 1: Evidence at protein level |
Target Main Class | Enzymes |
Target Subclass | 5.2.1.8 |
Gene Biotype | PROTEIN_CODING |
KINASE |
DRUGGABLE GENOME |
n/a |
Trial Name | GPI-1485 |
Novel drug target | Established target |
inhibitor (inhibitory) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | FK506-binding protein 1A inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | FK506-binding protein 1A inhibitor |
Direct Interaction | yes |
other/unknown |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | FK506-binding protein 1A inhibitor |
Trial Name | LCP-Siro, sirolimus |
inhibitor (inhibitory) |
Trial Name | tacrolimus hydrate,Prograf, Advagraf, Graceptor |
Novel drug target | Established target |
Trial Name | tacrolimus,LCP-Tacro |
inhibitor (inhibitory) |
Mechanism of Interaction | FK506-binding protein 1A inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | FK506-binding protein 1A inhibitor |
Direct Interaction | yes |
FKBP1A | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
FKBP1A | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:5.2.1.8 |
FK506-BINDING PROTEIN 1A (EC 5.2.1.8) (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE) (12 KDA FKBP) (FKBP-12) (IMMUNOPHILIN FKBP12). [SOURCE:UNIPROT/SWISSPROT;ACC:P62942] | Description |
ENSG00000088832 | Ensembl Gene Id |
FKBP1A | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ENSG00000088832 | Ensembl Gene Id |
P62942 | Uniprot Accession |
FKB1A_HUMAN | Uniprot Id |
Interpro Short Name | PPIase_FKBP_dom |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR001179 |
DRUGGABLE GENOME |
2280 | Entrez Gene Id |
FKBP1A | Gene Symbol |
ENSG00000088832 | Ensembl Gene Id |
Target Main Class | Enzymes |
Target Subclass | 5.2.1.8 |
ENSG00000088832 | Gene Symbol |
FKBP1A | Ensembl Id |
DRUGGABLE GENOME |
FKBP12 | GENE_SYMBOL |
FKBP1A | GENE_SYMBOL |
Peptidyl-prolyl cis-trans isomerase FKBP1A | UNIPROT |
FKBP1A | TTD Gene Abbreviation |
T76059 | TTD Target ID |
PPI | TTD Gene Abbreviation |
T07601 | TTD Target ID |
Peptidyl-prolyl cis-trans isomerase FKBP1A | Gene Name |
P62942 | UniProt ID |
KINASE |