DGIdb - FLT1 Gene Record

FLT1 2321 Druggable GenomeClinically Actionable

Alternate Names:

2321
FMS RELATED TYROSINE KINASE 1
FLT1
FLT
FLT-1
VEGFR-1
VEGFR1
165070
3763
ENSG00000102755
OTTHUMG00000016648
P17948
Vascular endothelial growth factor receptor 1
Vascular permeability factor receptor
FRT
Fms-like tyrosine kinase 1
Tyrosine-protein kinase FRT
Tyrosine-protein kinase receptor FLT
PA28180
VGFR1_HUMAN
VEGFR
VEGFR1/2/3
VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 PRECURSOR (EC 2.7.1.112) (VEGFR-1) (VASCULAR PERMEABILITY FACTOR RECEPTOR) (TYROSINE-PROTEIN KINASE RECEPTOR FLT) (FLT-1) (TYROSINE-PROTEIN KINASE FRT) (FMS-LIKE TYROSINE KINASE 1). [SOURCE:UNIPROT/SWISSPROT;A
fms related receptor tyrosine kinase 1
T63966

Gene Info:

Target Class	Receptors
Target Subclass	EC:2.7.10.1
Target Subclass	Other
Target Subclass	Kinase
Transmembrane Helix Count	1
Target Main Class	Receptors
CancerCommons Reported Gene Name	VEGFR
CancerCommons Reported Gene Name	FGFR3 and others (VEGFR)
CancerCommons Reported Gene Name	VEGF, PDGF
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Human Readable Name	KINASE
Interpro Type	Domain
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Interpro Acc	IPR001245
Uniprot Status	Swiss-Prot
Gene Biotype	PROTEIN_CODING

(18 More Sources)

Gene Categories: Category Details

KINASE
TYROSINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Hilberg et al., 2008, BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy., Cancer Res.
Wind S et al., 2019, Clinical Pharmacokinetics and Pharmacodynamics of Nintedanib., Clin Pharmacokinet
Cohen et al., 2008, Axitinib is an active treatment for all histologic subtypes of advanced thyroid cancer: results from a phase II study., J. Clin. Oncol.
Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
Perspicace E et al., 2013, Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2)., Eur J Med Chem
Dornbusch J et al., 2016, Evaluation of polymorphisms in angiogenesis-related genes as predictive and prognostic markers for sunitinib-treated metastatic renal cell carcinoma patients., J Cancer Res Clin Oncol
Quek R et al., 2009, Gastrointestinal stromal tumor: a clinical overview., Hematol Oncol Clin North Am
Roskoski, 2007, Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor., Biochem. Biophys. Res. Commun.
O'Farrell et al., 2003, An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients., Clin. Cancer Res.
Terakawa et al., 2013, Expression level of vascular endothelial growth factor receptor-2 in radical nephrectomy specimens as a prognostic predictor in patients with metastatic renal cell carcinoma treated with sunitinib., Urol. Oncol.
Dornbusch et al., 2013, Analyses of potential predictive markers and survival data for a response to sunitinib in patients with metastatic renal cell carcinoma., PLoS ONE
Carlomagno et al., 2006, BAY 43-9006 inhibition of oncogenic RET mutants., J. Natl. Cancer Inst.
Wilhelm et al., 2004, BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis., Cancer Res.
Wilhelm et al., 2006, Discovery and development of sorafenib: a multikinase inhibitor for treating cancer., Nat Rev Drug Discov
Gong L et al., 2017, PharmGKB summary: sorafenib pathways., Pharmacogenet Genomics
Sonpavde et al., 2007, Pazopanib: a novel multitargeted tyrosine kinase inhibitor., Curr Oncol Rep
Gingrich DE et al., 2003, A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055., J Med Chem
Yamamoto et al., 2007, Vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK 222584 inhibits both the induction and elicitation phases of contact hypersensitivity., J. Dermatol.
Matsui et al., 2008, E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition., Int. J. Cancer

VEGFRECINE FLT1

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CEP-5214 FLT1

Interaction Score: 0.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
14640546

Sources:
DTC ChemblInteractions
ICRUCUMAB FLT1

Interaction Score: 0.77

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor 1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FRUQUINTINIB FLT1

Interaction Score: 0.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

Trial Name fruquintinib

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
TIVOZANIB FLT1

Interaction Score: 0.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Novel drug target Established target

Trial Name AV-951

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions TTD
MOTESANIB FLT1

Interaction Score: 0.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name motesanib diphosphate, AMG 706

Novel drug target Established target

PMIDs:
20124951

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions PharmGKB
AXITINIB FLT1

Interaction Score: 0.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
18541897 20124951

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial PharmGKB
X-82 FLT1

Interaction Score: 0.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions TTD
TELBERMIN FLT1

Interaction Score: 0.39

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VATALANIB FLT1

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Vatalanib

Novel drug target Established target

Trial Name vatalanib, PTK 787

PMIDs:
17584317

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions
SURUFATINIB FLT1

Interaction Score: 0.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
GLESATINIB FLT1

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name MGCD265

Novel drug target Established target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial
SUNITINIB FLT1

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Sutent

Novel drug target Established target

Notes

PMIDs:
23583911 26935927 20124951 19248971 17367763 14654525 21478036 24086736

Sources:
TALC DTC TdgClinicalTrial TEND MyCancerGenomeClinicalTrial PharmGKB
CEP-7055 FLT1

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LENVATINIB MESYLATE FLT1

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
KRN-633 FLT1

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ABICIPAR PEGOL FLT1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MP0112

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
LUCITANIB FLT1

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions MyCancerGenomeClinicalTrial
AG-13958 FLT1

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
L-21649 FLT1

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FAMITINIB FLT1

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
TESEVATINIB FLT1

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name XL647

Novel drug target Established target

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial
NINTEDANIB FLT1

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name BIBF-1120,Vargatef

Novel drug target Established target

PMIDs:
18559524 31016670

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial
4SC-203 FLT1

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LENVATINIB FLT1

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name E7080

Novel drug target Established target

Notes

PMIDs:
17943726

Sources:
TALC TdgClinicalTrial
CHIAURANIB FLT1

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OSI-930 FLT1

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TAK-593 FLT1

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
CEP-11981 FLT1

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
AEE-788 FLT1

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor 1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FORETINIB FLT1

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions
MGCD-265 FLT1

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
XL-820 FLT1

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PEGPLERANIB SODIUM FLT1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name E-10030

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
TELATINIB FLT1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name telatinib

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
PAZOPANIB FLT1

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name Pazopanib

Novel drug target Established target

PMIDs:
17288876

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial MyCancerGenomeClinicalTrial
BRIVANIB ALANINATE FLT1

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SU-014813 FLT1

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BMS-690514 FLT1

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
REGORAFENIB FLT1

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions MyCancerGenomeClinicalTrial
CEDIRANIB FLT1

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name cediranib, AZD2171,Recentin

Novel drug target Established target

PMIDs:
None found

Sources:
TALC DTC TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions CancerCommons
CP-459632 FLT1

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RABEPRAZOLE SODIUM FLT1

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome TTD
NINTEDANIB ESYLATE FLT1

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORANTINIB FLT1

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
SUNITINIB MALATE FLT1

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
MUPARFOSTAT FLT1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Muparfostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SORAFENIB FLT1

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
16507829 15466206 17016424 28362716

Sources:
DTC MyCancerGenome MyCancerGenomeClinicalTrial PharmGKB
VANDETANIB FLT1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Zactima

Novel drug target Established target

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
DTC TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions MyCancerGenomeClinicalTrial
PAZOPANIB HYDROCHLORIDE FLT1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
XL-999 FLT1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BRIVANIB FLT1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SEMAXANIB FLT1

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SORAFENIB TOSYLATE FLT1

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TG100-801 FLT1

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor 1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
LINIFANIB FLT1

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

Trial Name ABT-869, Linifanib

PMIDs:
None found

Sources:
DTC MyCancerGenome TdgClinicalTrial ChemblInteractions
DOVITINIB FLT1

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

Reported Cancer Type Prostate

PMIDs:
None found

Sources:
DTC TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions CancerCommons
DORAMAPIMOD FLT1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZD-1152-HQPA FLT1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENMD-2076 FLT1

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
AST-487 FLT1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW843682X FLT1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALISERTIB FLT1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1997335 FLT1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OSI-632 FLT1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 FLT1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 FLT1

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions
KENPAULLONE FLT1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ERLOTINIB FLT1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
JNJ-7706621 FLT1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-0166285 FLT1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB FLT1

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
DTC ChemblInteractions
ENTRECTINIB FLT1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB FLT1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 FLT1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 FLT1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 FLT1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 FLT1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 FLT1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB FLT1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000102755
- Version: 101_38
Alternate Names:

FLT1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P17948
- Version: January-2014
Alternate Names:

FLT1 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass EC:2.7.10.1

Publications:
TEND: P17948
- Version: 01-August-2011
Alternate Names:

ENSG00000102755 Ensembl Gene Id

2321 Entrez Gene Id

FLT1 Gene Symbol

Gene Info:

Target Subclass Other

Target Subclass Kinase

Transmembrane Helix Count 1

Publications:
HopkinsGroom: P17948
- Version: 11-September-2012
Alternate Names:

FLT1 Uniprot Gene Name

ENSG00000102755 Ensembl Gene Id

VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 Uniprot Protein Name

Gene Info:

Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain

Human Readable Name KINASE

Interpro Type Domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
CancerCommons: FLT1
- Version: 25-July-2013
Alternate Names:

2321 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name VEGFR

CancerCommons Reported Gene Name FGFR3 and others (VEGFR)

CancerCommons Reported Gene Name VEGF, PDGF

Publications:

RussLampel: ENSG00000102755

Version: 26-July-2011

Alternate Names:

ENSG00000102755 Ensembl Gene Id

VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1 PRECURSOR (EC 2.7.1.112) (VEGFR-1) (VASCULAR PERMEABILITY FACTOR RECEPTOR) (TYROSINE-PROTEIN KINASE RECEPTOR FLT) (FLT-1) (TYROSINE-PROTEIN KINASE FRT) (FMS-LIKE TYROSINE KINASE 1). [SOURCE:UNIPROT/SWISSPROT;A Description

FLT1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: FLT1

Version: 18-August-2020

Alternate Names:

PA28180 PharmGKB ID

Gene Info:

Publications:

Quek R et al., 2009, Gastrointestinal stromal tumor: a clinical overview., Hematol Oncol Clin North Am

Dornbusch J et al., 2016, Evaluation of polymorphisms in angiogenesis-related genes as predictive and prognostic markers for sunitinib-treated metastatic renal cell carcinoma patients., J Cancer Res Clin Oncol

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

DTC: FLT1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Perspicace E et al., 2013, Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2)., Eur J Med Chem

Gingrich DE et al., 2003, A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055., J Med Chem

TALC: VEGFR-1
- Version: 12-May-2016
Alternate Names:

VEGFR-1 Gene Symbol

Gene Info:

Publications:
MyCancerGenome: VEGFR1
- Version: 20-Jun-2017
Alternate Names:

2321 Entrez Gene Id

VEGFR1 MyCancerGenome Gene Symbol

VEGFR1 MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000102755
- Version: 31-May-2017
Alternate Names:

ENSG00000102755 Gene Symbol

FLT1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: FLT1
- Version: 20-Jun-2017
Alternate Names:

2321 Entrez Gene Id

FLT1 MyCancerGenome Gene Symbol

VEGFR1/2/3 MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: FLT
- Version: chembl_23
Alternate Names:

FRT GENE_SYMBOL

VEGFR1 GENE_SYMBOL

FLT1 GENE_SYMBOL

Gene Info:

Publications:
Tempus: FLT1
- Version: 11-November-2018
Alternate Names:

FLT1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: FLT1
- Version: 27-Jun-2013
Alternate Names:

2321 Gene ID

FLT dGene Synonym

FLT-1 dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
TTD: Vascular endothelial growth factor receptor 1
- Version: 2020.06.01
Alternate Names:

FLT-1 TTD Gene Abbreviation

T63966 TTD Target ID

Gene Info:

Publications:
Pharos: FLT1
- Version: 01-February-2022
Alternate Names:

Vascular endothelial growth factor receptor 1 Gene Name

P17948 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
ClearityFoundationClinicalTrial: FLT1
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
MyCancerGenomeClinicalTrial: FLT1
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
MskImpact: FLT1
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: FLT1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: FLT1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Vascular endothelial growth factor receptor inhibitor
Direct Interaction	yes

Notes
Trial Name	motesanib diphosphate, AMG 706
Novel drug target	Established target

Reported Cancer Type	Prostate
Mechanism of Interaction	Vascular endothelial growth factor receptor inhibitor
Direct Interaction	yes

Trial Name	Vatalanib
Novel drug target	Established target
Trial Name	vatalanib, PTK 787

Notes
Trial Name	BIBF-1120,Vargatef
Novel drug target	Established target

Notes
Trial Name	cediranib, AZD2171,Recentin
Novel drug target	Established target

Trial Name	Zactima
Novel drug target	Established target
Mechanism of Interaction	Vascular endothelial growth factor receptor inhibitor

ENSG00000102755	Ensembl Gene Id
2321	Entrez Gene Id
FLT1	Gene Symbol

FLT1	Uniprot Gene Name
ENSG00000102755	Ensembl Gene Id
VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1	Uniprot Protein Name

Vascular endothelial growth factor receptor 1	Gene Name
P17948	UniProt ID

FLT1 Gene Record

FLT1 2321 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: 14640546

Sources: DTC ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor 1 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes Trial Name fruquintinib

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Novel drug target Established target Trial Name AV-951

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name motesanib diphosphate, AMG 706 Novel drug target Established target

PMIDs: 20124951

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Prostate Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: 18541897 20124951

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: MyCancerGenome ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Vatalanib Novel drug target Established target Trial Name vatalanib, PTK 787

PMIDs: 17584317

Sources: TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Trial Name MGCD265 Novel drug target Established target

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Sutent Novel drug target Established target Notes

PMIDs: 23583911 26935927 20124951 19248971 17367763 14654525 21478036 24086736

Sources: TALC DTC TdgClinicalTrial TEND MyCancerGenomeClinicalTrial PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name MP0112 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions MyCancerGenomeClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
14640546

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor 1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

Trial Name fruquintinib

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Novel drug target Established target

Trial Name AV-951

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name motesanib diphosphate, AMG 706

Novel drug target Established target

PMIDs:
20124951

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
18541897 20124951

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions CancerCommons MyCancerGenomeClinicalTrial PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Vatalanib

Novel drug target Established target

Trial Name vatalanib, PTK 787

PMIDs:
17584317

Sources:
TALC DTC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Trial Name MGCD265

Novel drug target Established target

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Sutent

Novel drug target Established target

Notes

PMIDs:
23583911 26935927 20124951 19248971 17367763 14654525 21478036 24086736

Sources:
TALC DTC TdgClinicalTrial TEND MyCancerGenomeClinicalTrial PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name MP0112

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)