DGIdb - GABRR2 Gene Record

GABRR2 2570 Druggable Genome

Alternate Names:

2570
GAMMA-AMINOBUTYRIC ACID TYPE A RECEPTOR RHO2 SUBUNIT
GABRR2
137162
4091
ENSG00000111886
OTTHUMG00000015198
P28476
GBRR2_HUMAN
GAMMA-AMINOBUTYRIC-ACID RECEPTOR RHO-2 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P28476]
GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT RHO-2
gamma-aminobutyric acid type A receptor subunit rho2

Gene Info:

Target Subclass	Channels
Target Main Class	Receptors
Transmembrane Helix Count	4
Target Subclass	cys-loop
Target Subclass	Ligand_gated_ion_channels
Target Class	Receptors
Target Subclass	TC:1.A.9
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Short Name	Neur_channel
Interpro Type	Domain
Human Readable Name	ION CHANNEL
Uniprot Evidence	2: Evidence at transcript level
Interpro Acc	IPR006201
Interpro Type	Family
Interpro Name	Neurotransmitter-gated ion-channel ligand-binding
Interpro Short Name	Neur_chan_lig-bd
Interpro Acc	IPR006202
Interpro Name	Neurotransmitter-gated ion-channel
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Iorio et al., 1984, Selective affinity of 1-N-trifluoroethyl benzodiazepines for cerebellar type 1 receptor sites., Life Sci.
Wamsley et al., 1985, Autoradiographic demonstration of the selectivity of two 1-N-trifluoroethyl benzodiazepines for the BZD-1 receptors in the rat brain., Pharmacol. Biochem. Behav.
Giersch et al., 2010, Atypical behavioural effects of lorazepam: clues to the design of novel therapies?, Pharmacol. Ther.
Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
Möhler et al., 2002, A new benzodiazepine pharmacology., J. Pharmacol. Exp. Ther.
Schove et al., 1994, Molecular determinants of recognition and activation at the cerebellar benzodiazepine receptor site., Bioorg. Med. Chem.
Nakatsuka et al., 1985, Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity., Life Sci.
Lahti et al., 1983, Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine., Neuropharmacology
Sethy et al., 1984, Determination of biological activity of adinazolam and its metabolites., J. Pharm. Pharmacol.
Mandrioli et al., 2008, Benzodiazepine metabolism: an analytical perspective., Curr. Drug Metab.
Walash et al., 1994, A selective fluorimetric method for the determination of some 1,4-benzodiazepine drugs containing a hydroxyl group at C-3., J Pharm Biomed Anal
Braestrup et al., 1978, Pharmacological characterization of benzodiazepine receptors in the brain., Eur. J. Pharmacol.
Miller et al., 1987, Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam., J. Neurochem.
Billard et al., 1988, Selective affinity of the benzodiazepines quazepam and 2-oxo-quazepam for BZ1 binding site and demonstration of 3H-2-oxo-quazepam as a BZ1 selective radioligand., Life Sci.
Meldrum et al., 1986, Benzodiazepine receptors and their relationship to the treatment of epilepsy., Epilepsia

ADINAZOLAM GABRR2

Interaction Score: 0.58

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
QUAZEPAM GABRR2

Interaction Score: 0.49

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2892106 3017690

Sources:
TdgClinicalTrial TEND
HALAZEPAM GABRR2

Interaction Score: 0.49

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6738302 2867566

Sources:
TdgClinicalTrial TEND
NITRAZEPAM GABRR2

Interaction Score: 0.47

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
FLURAZEPAM GABRR2

Interaction Score: 0.47

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
TEMAZEPAM GABRR2

Interaction Score: 0.45

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
20138190 18384456

Sources:
TdgClinicalTrial TEND
CINOLAZEPAM GABRR2

Interaction Score: 0.44

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7849137

Sources:
TdgClinicalTrial TEND
CLOTIAZEPAM GABRR2

Interaction Score: 0.44

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
18855614

Sources:
TdgClinicalTrial TEND
FLUDIAZEPAM GABRR2

Interaction Score: 0.44

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2857046

Sources:
TdgClinicalTrial TEND
ESTAZOLAM GABRR2

Interaction Score: 0.43

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
639854 2889803

Sources:
TdgClinicalTrial TEND
OXAZEPAM GABRR2

Interaction Score: 0.38

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
BROMAZEPAM GABRR2

Interaction Score: 0.35

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18384456

Sources:
TdgClinicalTrial TEND
PRAZEPAM GABRR2

Interaction Score: 0.34

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7773620

Sources:
TdgClinicalTrial TEND
TRIAZOLAM GABRR2

Interaction Score: 0.33

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
DIAZEPAM GABRR2

Interaction Score: 0.33

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name diazepam rectal gel

Novel drug target Established target

Trial Name NRL-01

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
MIDAZOLAM GABRR2

Interaction Score: 0.27

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND
CLORAZEPIC ACID GABRR2

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
CHLORDIAZEPOXIDE GABRR2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
CLOBAZAM GABRR2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Clobazam

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
LORAZEPAM GABRR2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
CLONAZEPAM GABRR2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name JZP-8

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
ALPRAZOLAM GABRR2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name alprazolam,Xanax, Xanax XR

Novel drug target Established target

Trial Name AZ-002, Staccato alprazolam

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
REMIMAZOLAM GABRR2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name CNS-7056

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
OCINAPLON GABRR2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ocinaplon

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ADIPIPLON GABRR2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name NG2-73

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Ensembl: ENSG00000111886
- Version: 101_38
Alternate Names:

GABRR2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P28476
- Version: 01-August-2011
Alternate Names:

P28476 Uniprot Accession

GBRR2_HUMAN Uniprot Id

ENSG00000111886 Ensembl Gene Id

Gene Info:

Target Subclass Channels

Target Main Class Receptors

Transmembrane Helix Count 4

Publications:
TdgClinicalTrial: P28476
- Version: January-2014
Alternate Names:

GABRR2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass TC:1.A.9

Publications:
HopkinsGroom: P28476
- Version: 11-September-2012
Alternate Names:

GABRR2 Uniprot Gene Name

P28476 Uniprot Accession

GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT RHO-2 Uniprot Protein Name

Gene Info:

Interpro Short Name Neur_channel

Interpro Type Domain

Human Readable Name ION CHANNEL

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000111886
- Version: 26-July-2011
Alternate Names:

ENSG00000111886 Ensembl Gene Id

GABRR2 Display Id

GAMMA-AMINOBUTYRIC-ACID RECEPTOR RHO-2 SUBUNIT PRECURSOR (GABA(A) RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P28476] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HingoraniCasas: ENSG00000111886
- Version: 31-May-2017
Alternate Names:

ENSG00000111886 Gene Symbol

GABRR2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: GABRR2
- Version: 01-February-2022
Alternate Names:

Gamma-aminobutyric acid receptor subunit rho-2 Gene Name

P28476 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Trial Name	ARX-03, sufentanil + triazolam NanoTab
Novel drug target	Established target

Trial Name	diazepam rectal gel
Novel drug target	Established target
Trial Name	NRL-01

Trial Name	alprazolam,Xanax, Xanax XR
Novel drug target	Established target
Trial Name	AZ-002, Staccato alprazolam

P28476	Uniprot Accession
GBRR2_HUMAN	Uniprot Id
ENSG00000111886	Ensembl Gene Id

GABRR2	Uniprot Gene Name
P28476	Uniprot Accession
GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT RHO-2	Uniprot Protein Name

Gamma-aminobutyric acid receptor subunit rho-2	Gene Name
P28476	UniProt ID

GABRR2 Gene Record

GABRR2 2570 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2892106 3017690

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6738302 2867566

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752090 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752090 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 20138190 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 7849137

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 18855614

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2857046

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 639854 2889803

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752090 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 7773620

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name ARX-03, sufentanil + triazolam NanoTab Novel drug target Established target

PMIDs: 11752090 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name diazepam rectal gel Novel drug target Established target Trial Name NRL-01

PMIDs: 11752090 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11752090 18384456

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Clobazam Novel drug target Established target

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2892106 3017690

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6738302 2867566

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
20138190 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7849137

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
18855614

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2857046

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
639854 2889803

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
7773620

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name ARX-03, sufentanil + triazolam NanoTab

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name diazepam rectal gel

Novel drug target Established target

Trial Name NRL-01

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11752090 18384456

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Clobazam

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND