DGIdb - GC Gene Record

GC 2638 Druggable Genome

Alternate Names:

2638
GC, VITAMIN D BINDING PROTEIN
GC
DBP
DBP/GC
GRD3
Gc-MAF
GcMAF
HEL-S-51
VDBG
VDBP
139200
4187
ENSG00000145321
OTTHUMG00000129915
Vitamin K gamma glutamyl carboxylase
Gamma-glutamyl carboxylase
Peptidyl-glutamate 4-carboxylase
Vitamin K-dependent gamma-carboxylase
GGCX
PA28601
Guanylate cyclase
T71398
GC VITAMIN D BINDING PROTEIN
DBP-maf
VDB

Gene Info:

Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Berger MD et al., 2018, A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab., Clin Cancer Res
López-Farré et al., 2007, Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients: a proteomic study., J. Proteome Res.
Allegra S et al., 2019, The effect of vitamin D pathway genes and deferasirox pharmacogenetics on liver iron in thalassaemia major patients., Pharmacogenomics J

AFEGOSTAT TARTRATE GC

Interaction Score: 8.83

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-glucocerebrosidase stabiliser

PMIDs:
None found

Sources:
ChemblInteractions
PIRSIDOMINE GC

Interaction Score: 8.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DEFERASIROX GC

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30651574

Sources:
PharmGKB
ANISINDIONE GC

Interaction Score: 1.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vitamin K-dependent gamma-carboxylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BEVACIZUMAB GC

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29208668

Sources:
PharmGKB
CETUXIMAB GC

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29208668

Sources:
PharmGKB
ASPIRIN GC

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17555340

Sources:
NCI

Ensembl: ENSG00000145321
- Version: 101_38
Alternate Names:

GC Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: GC

Version: 18-August-2020

Alternate Names:

PA28601 PharmGKB ID

Gene Info:

Publications:

Berger MD et al., 2018, A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab., Clin Cancer Res

Allegra S et al., 2019, The effect of vitamin D pathway genes and deferasirox pharmacogenetics on liver iron in thalassaemia major patients., Pharmacogenomics J

NCI: GC

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Fainaru et al., 1979, A method for studying plasma transport of vitamin D applicable to hypervitaminosis D., Clin. Chim. Acta

López-Farré et al., 2007, Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients: a proteomic study., J. Proteome Res.

ChemblInteractions: GC
- Version: chembl_23
Alternate Names:

GC GENE_SYMBOL

GGCX GENE_SYMBOL

Vitamin K-dependent gamma-carboxylase UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000145321
- Version: 31-May-2017
Alternate Names:

ENSG00000145321 Gene Symbol

GC Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Guanylate cyclase
- Version: 2020.06.01
Alternate Names:

GC TTD Gene Abbreviation

T71398 TTD Target ID

Gene Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Beta-glucocerebrosidase stabiliser

Mechanism of Interaction	Vitamin K-dependent gamma-carboxylase inhibitor
Direct Interaction	yes

GC	GENE_SYMBOL
GGCX	GENE_SYMBOL
Vitamin K-dependent gamma-carboxylase	UNIPROT

ENSG00000145321	Gene Symbol
GC	Ensembl Id

GC	TTD Gene Abbreviation
T71398	TTD Target ID

GC Gene Record

GC 2638 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

AFEGOSTAT TARTRATE GC

Interaction Types & Directionality: n/a

Interaction Info: Direct Interaction yes Mechanism of Interaction Beta-glucocerebrosidase stabiliser

PMIDs: None found

Sources: ChemblInteractions

PIRSIDOMINE GC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

DEFERASIROX GC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30651574

Sources: PharmGKB

ANISINDIONE GC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vitamin K-dependent gamma-carboxylase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

BEVACIZUMAB GC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29208668

Sources: PharmGKB

CETUXIMAB GC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29208668

Sources: PharmGKB

ASPIRIN GC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17555340

Sources: NCI

Ensembl: ENSG00000145321

Alternate Names: GC Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: GC

Alternate Names: PA28601 PharmGKB ID

Gene Info:

NCI: GC

Alternate Names:

Gene Info:

ChemblInteractions: GC

Alternate Names: GC GENE_SYMBOL GGCX GENE_SYMBOL Vitamin K-dependent gamma-carboxylase UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000145321

Alternate Names: ENSG00000145321 Gene Symbol GC Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TTD: Guanylate cyclase

Alternate Names: GC TTD Gene Abbreviation T71398 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Beta-glucocerebrosidase stabiliser

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
30651574

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vitamin K-dependent gamma-carboxylase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
29208668

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29208668

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17555340

Sources:
NCI

Alternate Names:

GC Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA28601 PharmGKB ID

Alternate Names:

GC GENE_SYMBOL

GGCX GENE_SYMBOL

Vitamin K-dependent gamma-carboxylase UNIPROT

Alternate Names:

ENSG00000145321 Gene Symbol

GC Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GC TTD Gene Abbreviation

T71398 TTD Target ID