DGIdb - GNRHR2 Gene Record

GNRHR2 114814 Druggable Genome

Alternate Names:

114814
GONADOTROPIN RELEASING HORMONE RECEPTOR 2 (PSEUDOGENE)
GNRHR2
GnRH-II-R
612875
16341
ENSG00000211451
Q96P88
ENSG00000180290
GONADOTROPIN-RELEASING HORMONE II RECEPTOR (TYPE II GNRH RECEPTOR) (GNRH-II-R). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96P88]
GNRR2_HUMAN

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Transmembrane Helix Count	4
Target Main Class	Receptors
Gene Biotype	TRANSCRIBED_UNITARY_PSEUDOGENE

(3 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Barbieri, 1990, Comparison of the pharmacology of nafarelin and danazol., Am. J. Obstet. Gynecol.
Saltiel et al., 1991, Pharmacologic management of endometriosis., Clin Pharm
Garner, 1994, Uses of GnRH agonists., J Obstet Gynecol Neonatal Nurs
Batzer, GnRH analogs: options for endometriosis-associated pain treatment., J Minim Invasive Gynecol
Chrisp et al., 1990, Nafarelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical potential in sex hormone-related conditions., Drugs
Hugues et al., Revisiting gonadotrophin-releasing hormone agonist protocols and management of poor ovarian responses to gonadotrophins., Hum. Reprod. Update
Letassy et al., 1990, Nafarelin acetate: a gonadotropin-releasing hormone agonist for the treatment of endometriosis., DICP
Valle et al., 2003, Endometriosis: treatment strategies., Ann. N. Y. Acad. Sci.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Suh et al., 2004, Dose of GnRH agonist (nafarelin acetate) affects intrafollicular PAPP-A expression in controlled ovarian hyperstimulation cycle., Eur. J. Obstet. Gynecol. Reprod. Biol.
Morgan et al., 2006, Bovine and ovine gonadotropin-releasing hormone (GnRH)-II ligand precursors and type II GnRH receptor genes are functionally inactivated., Endocrinology
Li et al., 2005, Extracellular loop 3 (EL3) and EL3-proximal transmembrane helix 7 of the mammalian type I and type II gonadotropin-releasing hormone (GnRH) receptors determine differential ligand selectivity to GnRH-I and GnRH-II., Mol. Pharmacol.
Silver et al., 2006, Functional characterization and kinetic studies of an ancestral lamprey GnRH-III selective type II GnRH receptor from the sea lamprey, Petromyzon marinus., J. Mol. Endocrinol.
Montagnani Marelli et al., 2006, Gonadotropin-releasing hormone (GnRH) receptors in tumors: a new rationale for the therapeutical application of GnRH analogs in cancer patients?, Curr Cancer Drug Targets
Mamputha et al., 2007, Conserved amino acid residues that are important for ligand binding in the type I gonadotropin-releasing hormone (GnRH) receptor are required for high potency of GnRH II at the type II GnRH receptor., Mol. Endocrinol.
Menon et al., 1986, Inhibition of gonadotropin-releasing hormone receptors in rat anterior pituitary monolayer cell cultures by danazol., Am. J. Obstet. Gynecol.
Dmowski, 1990, Danazol. A synthetic steroid with diverse biologic effects., J Reprod Med

NAFARELIN GNRHR2

Interaction Score: 50.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2137975 1830521 7996307 17097577 2140979 9622415 2151003 14644830 17016423 17139284 14687742

Sources:
TdgClinicalTrial TEND
GONADORELIN GNRHR2

Interaction Score: 27.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16916952 15635044 16720727 16712461 16973761

Sources:
TdgClinicalTrial TEND
EP-100 GNRHR2

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name EP-100

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
HISTRELIN GNRHR2

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name VP 002, histrelin implant,Vantas, Supprelin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
CHEMBL179691 GNRHR2

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GnRH receptor antagonist, NBI-42902

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
OZARELIX GNRHR2

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name SPI-153, D-63153,Ozarelix

PMIDs:
None found

Sources:
TdgClinicalTrial
DEGARELIX GNRHR2

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Degarelix

PMIDs:
None found

Sources:
TdgClinicalTrial
DANAZOL GNRHR2

Interaction Score: 2.9

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
3004220 17016423 17139284 2404115

Sources:
TdgClinicalTrial TEND

Ensembl: ENSG00000211451
- Version: 101_38
Alternate Names:

GNRHR2 Ensembl Gene Name

Gene Info:

Gene Biotype TRANSCRIBED_UNITARY_PSEUDOGENE

Publications:
TEND: Q96P88
- Version: 01-August-2011
Alternate Names:

ENSG00000211451 Ensembl Gene Id

GNRR2_HUMAN Uniprot Id

Q96P88 Uniprot Accession

Gene Info:

Transmembrane Helix Count 4

Target Main Class Receptors

Target Subclass GPCR

Publications:
TdgClinicalTrial: Q96P88
- Version: January-2014
Alternate Names:

GNRHR2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
RussLampel: ENSG00000180290
- Version: 26-July-2011
Alternate Names:

ENSG00000180290 Ensembl Gene Id

GNRHR2 Display Id

GONADOTROPIN-RELEASING HORMONE II RECEPTOR (TYPE II GNRH RECEPTOR) (GNRH-II-R). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96P88] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
IDG: GNRHR2
- Version: 15-July-2019
Alternate Names:

GNRHR2 Gene Symbol

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: GNRHR2
- Version: 27-Jun-2013
Alternate Names:

114814 Gene ID

GnRH-II-R dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
GO: GNRHR2
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Trial Name	VP 002, histrelin implant,Vantas, Supprelin
Novel drug target	Established target

Trial Name	GnRH receptor antagonist, NBI-42902
Novel drug target	Established target

ENSG00000211451	Ensembl Gene Id
GNRR2_HUMAN	Uniprot Id
Q96P88	Uniprot Accession

GNRHR2 Gene Record

GNRHR2 114814 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2137975 1830521 7996307 17097577 2140979 9622415 2151003 14644830 17016423 17139284 14687742

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16916952 15635044 16720727 16712461 16973761

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name EP-100 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name VP 002, histrelin implant,Vantas, Supprelin Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name GnRH receptor antagonist, NBI-42902 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name SPI-153, D-63153,Ozarelix

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name Degarelix

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: negative modulator (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 3004220 17016423 17139284 2404115

Sources: TdgClinicalTrial TEND

Ensembl: ENSG00000211451

Alternate Names: GNRHR2 Ensembl Gene Name

Gene Info: Gene Biotype TRANSCRIBED_UNITARY_PSEUDOGENE

Publications:

TEND: Q96P88

Alternate Names: ENSG00000211451 Ensembl Gene Id GNRR2_HUMAN Uniprot Id Q96P88 Uniprot Accession

Gene Info: Transmembrane Helix Count 4 Target Main Class Receptors Target Subclass GPCR

Publications:

TdgClinicalTrial: Q96P88

Alternate Names: GNRHR2 Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Rhodopsin

Publications:

RussLampel: ENSG00000180290

Alternate Names: ENSG00000180290 Ensembl Gene Id GNRHR2 Display Id GONADOTROPIN-RELEASING HORMONE II RECEPTOR (TYPE II GNRH RECEPTOR) (GNRH-II-R). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96P88] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

IDG: GNRHR2

Alternate Names: GNRHR2 Gene Symbol

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

dGene: GNRHR2

Alternate Names: 114814 Gene ID GnRH-II-R dGene Synonym

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

GO: GNRHR2

Alternate Names:

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2137975 1830521 7996307 17097577 2140979 9622415 2151003 14644830 17016423 17139284 14687742

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16916952 15635044 16720727 16712461 16973761

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name EP-100

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name VP 002, histrelin implant,Vantas, Supprelin

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name GnRH receptor antagonist, NBI-42902

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name SPI-153, D-63153,Ozarelix

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Degarelix

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

negative modulator (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
3004220 17016423 17139284 2404115

Sources:
TdgClinicalTrial TEND

Alternate Names:

GNRHR2 Ensembl Gene Name

Gene Info:

Gene Biotype TRANSCRIBED_UNITARY_PSEUDOGENE

Alternate Names:

ENSG00000211451 Ensembl Gene Id

GNRR2_HUMAN Uniprot Id

Q96P88 Uniprot Accession

Gene Info:

Transmembrane Helix Count 4

Target Main Class Receptors

Target Subclass GPCR

Alternate Names:

GNRHR2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Alternate Names:

ENSG00000180290 Ensembl Gene Id

GNRHR2 Display Id

GONADOTROPIN-RELEASING HORMONE II RECEPTOR (TYPE II GNRH RECEPTOR) (GNRH-II-R). [SOURCE:UNIPROT/SWISSPROT;ACC:Q96P88] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GNRHR2 Gene Symbol

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

114814 Gene ID

GnRH-II-R dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Gene Categories:

G PROTEIN COUPLED RECEPTOR