2890 |
GLUTAMATE IONOTROPIC RECEPTOR AMPA TYPE SUBUNIT 1 |
GRIA1 |
GLUH1 |
GLUR1 |
GLURA |
GluA1 |
HBGR1 |
138248 |
4571 |
ENSG00000155511 |
OTTHUMG00000130148 |
P42261 |
GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1 |
GLUR-1 |
GLUR-K1 |
GLUTAMATE RECEPTOR 1 |
GLUR-A |
AMPA-SELECTIVE GLUTAMATE RECEPTOR 1 |
GLUTAMATE RECEPTOR 1 PRECURSOR (GLUR-1) (GLUR-A) (GLUR-K1) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P42261] |
GRIA1_HUMAN |
PA28966 |
Glutamate receptor AMPA 1 |
T33584 |
Human Readable Name | DRUGGABLE GENOME |
Target Class | Receptors |
Target Subclass | TC:1.A.10.1 |
Uniprot Status | Swiss-Prot |
Interpro Name | Ionotropic glutamate receptor |
Interpro Acc | IPR001320 |
Interpro Type | Domain |
Interpro Short Name | Iontro_glu_rcpt |
Uniprot Evidence | 1: Evidence at protein level |
Target Subclass | Channels |
Target Subclass | Ligand_gated_ion_channels |
Target Subclass | Glutamate |
Transmembrane Helix Count | 3 |
Target Main Class | Receptors |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
ION CHANNEL |
DRUGGABLE GENOME |
n/a |
Trial Name | talampanel |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA antagonist |
Trial Name | E2007 |
positive modulator (activating) |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA positive allosteric modulator |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA antagonist |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA positive allosteric modulator |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA antagonist |
Trial Name | BGG-492 |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA positive allosteric modulator |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | tezampanel, NGX424,NGX426 |
Novel drug target | Established target |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA antagonist |
Direct Interaction | yes |
n/a |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate receptor ionotropic AMPA antagonist |
Direct Interaction | yes |
GRIA1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
GRIA1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.10.1 |
GRIA1 | Display Id |
GLUTAMATE RECEPTOR 1 PRECURSOR (GLUR-1) (GLUR-A) (GLUR-K1) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P42261] | Description |
ENSG00000155511 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
GRIA1 | Uniprot Gene Name |
P42261 | Uniprot Accession |
ENSG00000155511 | Ensembl Gene Id |
Uniprot Status | Swiss-Prot |
Interpro Name | Ionotropic glutamate receptor |
Interpro Acc | IPR001320 |
DRUGGABLE GENOME |
GRIA1_HUMAN | Uniprot Id |
2890 | Entrez Gene Id |
P42261 | Uniprot Accession |
Target Subclass | Channels |
Target Subclass | Ligand_gated_ion_channels |
Target Subclass | Glutamate |
PA28966 | PharmGKB ID |
ENSG00000155511 | Gene Symbol |
GRIA1 | Ensembl Id |
DRUGGABLE GENOME |
GLUR1 | GENE_SYMBOL |
GRIA1 | GENE_SYMBOL |
Glutamate receptor 1 | UNIPROT |
GLUH1 | GO Gene Synonym |
GLUR1 | GO Gene Synonym |
CELL SURFACE |
GRIA1 | TTD Gene Abbreviation |
T33584 | TTD Target ID |
Glutamate receptor 1 | Gene Name |
P42261 | UniProt ID |
ION CHANNEL |