DGIdb - GRIA3 Gene Record

GRIA3 2892 Druggable Genome

Alternate Names:

2892
GLUTAMATE IONOTROPIC RECEPTOR AMPA TYPE SUBUNIT 3
GRIA3
GLUR-C
GLUR-K3
GLUR3
GLURC
GluA3
MRX94
305915
4573
ENSG00000125675
OTTHUMG00000022685
P42263
GRIA3_HUMAN
GLUTAMATE RECEPTOR 3
Glutamate receptor ionotropic, AMPA 3
AMPA-selective glutamate receptor 3
GluR-3
GLUTAMATE RECEPTOR 3 PRECURSOR (GLUR-3) (GLUR-C) (GLUR-K3) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 3). [SOURCE:UNIPROT/SWISSPROT;ACC:P42263]
PA28968
Glutamate receptor AMPA 3
T62391
MRXSW

Gene Info:

Interpro Acc	IPR001320
Uniprot Status	Swiss-Prot
Interpro Short Name	Iontro_glu_rcpt
Interpro Type	Domain
Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Ionotropic glutamate receptor
Target Class	Receptors
Target Subclass	TC:1.A.10.1.4
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

TRANSPORTER
ION CHANNEL
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Laje G et al., 2007, Genetic markers of suicidal ideation emerging during citalopram treatment of major depression., Am J Psychiatry
Pu M et al., 2013, Influence of genetic polymorphisms in the glutamatergic and GABAergic systems and their interactions with environmental stressors on antidepressant response., Pharmacogenomics
Denes et al., 2006, Talampanel a non-competitive AMPA-antagonist attenuates caspase-3 dependent apoptosis in mouse brain after transient focal cerebral ischemia., Brain Res. Bull.
Howes et al., 2007, Talampanel., Neurotherapeutics
Langan et al., 2003, Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy., Epilepsia
Dildy-Mayfield et al., 1996, Anesthetics produce subunit-selective actions on glutamate receptors., J. Pharmacol. Exp. Ther.

TALAMPANEL GRIA3

Interaction Score: 3.64

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name talampanel

Novel drug target Established target

PMIDs:
16861112 17199027 12581229

Sources:
TdgClinicalTrial
PERAMPANEL GRIA3

Interaction Score: 2.73

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

Trial Name E2007

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
SELURAMPANEL GRIA3

Interaction Score: 0.91

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name BGG-492

Novel drug target Established target

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
MIBAMPATOR GRIA3

Interaction Score: 0.91

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CX1739 GRIA3

Interaction Score: 0.91

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PF-04958242 GRIA3

Interaction Score: 0.91

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BECAMPANEL GRIA3

Interaction Score: 0.91

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs:
None found

Sources:
ChemblInteractions
FARAMPATOR GRIA3

Interaction Score: 0.91

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions
ZONAMPANEL GRIA3

Interaction Score: 0.91

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MK-8777 GRIA3

Interaction Score: 0.91

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions
TEZAMPANEL GRIA3

Interaction Score: 0.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tezampanel, NGX424,NGX426

Novel drug target Established target

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
DASOLAMPANEL GRIA3

Interaction Score: 0.73

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VENLAFAXINE GRIA3

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23394390

Sources:
PharmGKB
IRAMPANEL GRIA3

Interaction Score: 0.26

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CITALOPRAM GRIA3

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17898344

Sources:
PharmGKB
PHENOBARBITAL GRIA3

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8786535

Sources:
NCI
TOPIRAMATE GRIA3

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000125675
- Version: 101_38
Alternate Names:

GRIA3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P42263
- Version: 11-September-2012
Alternate Names:

GLUTAMATE RECEPTOR 3 Uniprot Protein Name

ENSG00000125675 Ensembl Gene Id

GRIA3 Uniprot Gene Name

Gene Info:

Interpro Acc IPR001320

Uniprot Status Swiss-Prot

Interpro Short Name Iontro_glu_rcpt

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000125675

Version: 26-July-2011

Alternate Names:

GRIA3 Display Id

GLUTAMATE RECEPTOR 3 PRECURSOR (GLUR-3) (GLUR-C) (GLUR-K3) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 3). [SOURCE:UNIPROT/SWISSPROT;ACC:P42263] Description

ENSG00000125675 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P42263
- Version: January-2014
Alternate Names:

GRIA3 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass TC:1.A.10.1.4

Publications:

PharmGKB: GRIA3

Version: 18-August-2020

Alternate Names:

PA28968 PharmGKB ID

Gene Info:

Publications:

Laje G et al., 2007, Genetic markers of suicidal ideation emerging during citalopram treatment of major depression., Am J Psychiatry

Pu M et al., 2013, Influence of genetic polymorphisms in the glutamatergic and GABAergic systems and their interactions with environmental stressors on antidepressant response., Pharmacogenomics

NCI: GRIA3

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Chew et al., 1997, Growth factor-induced transcription of GluR1 increases functional AMPA receptor density in glial progenitor cells., J. Neurosci.

Dildy-Mayfield et al., 1996, Anesthetics produce subunit-selective actions on glutamate receptors., J. Pharmacol. Exp. Ther.

HingoraniCasas: ENSG00000125675
- Version: 31-May-2017
Alternate Names:

ENSG00000125675 Gene Symbol

GRIA3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: GLUR3
- Version: chembl_23
Alternate Names:

GLURC GENE_SYMBOL

GRIA3 GENE_SYMBOL

Glutamate receptor 3 UNIPROT

Gene Info:

Publications:
HumanProteinAtlas: GRIA3
- Version: 19.3
Alternate Names:

ENSG00000125675 Ensembl Gene ID

GluA3 Human Protein Atlas Gene Synonym

GLUR3 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
GO: GRIA3
- Version: 01-February-2022
Alternate Names:

GLUR3 GO Gene Synonym

GLURC GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Glutamate receptor AMPA 3
- Version: 2020.06.01
Alternate Names:

GRIA3 TTD Gene Abbreviation

T62391 TTD Target ID

Gene Info:

Publications:
Pharos: GRIA3
- Version: 01-February-2022
Alternate Names:

Glutamate receptor 3 Gene Name

P42263 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Mechanism of Interaction	Glutamate receptor ionotropic AMPA antagonist
Direct Interaction	yes
Trial Name	E2007

Trial Name	BGG-492
Novel drug target	Established target
Mechanism of Interaction	Glutamate receptor ionotropic AMPA antagonist

Mechanism of Interaction	Glutamate receptor ionotropic AMPA positive allosteric modulator
Direct Interaction	yes

Trial Name	tezampanel, NGX424,NGX426
Novel drug target	Established target
Mechanism of Interaction	Glutamate receptor ionotropic AMPA antagonist

GLUTAMATE RECEPTOR 3	Uniprot Protein Name
ENSG00000125675	Ensembl Gene Id
GRIA3	Uniprot Gene Name

GRIA3	Display Id
GLUTAMATE RECEPTOR 3 PRECURSOR (GLUR-3) (GLUR-C) (GLUR-K3) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 3). [SOURCE:UNIPROT/SWISSPROT;ACC:P42263]	Description
ENSG00000125675	Ensembl Gene Id

GRIA3 Gene Record

GRIA3 2892 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name talampanel Novel drug target Established target

PMIDs: 16861112 17199027 12581229

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes Trial Name E2007

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name BGG-492 Novel drug target Established target Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name tezampanel, NGX424,NGX426 Novel drug target Established target Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23394390

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17898344

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8786535

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000125675

Alternate Names: GRIA3 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P42263

Alternate Names: GLUTAMATE RECEPTOR 3 Uniprot Protein Name ENSG00000125675 Ensembl Gene Id GRIA3 Uniprot Gene Name

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name talampanel

Novel drug target Established target

PMIDs:
16861112 17199027 12581229

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

Trial Name E2007

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name BGG-492

Novel drug target Established target

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name tezampanel, NGX424,NGX426

Novel drug target Established target

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23394390

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
17898344

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8786535

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

GRIA3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

GLUTAMATE RECEPTOR 3 Uniprot Protein Name

ENSG00000125675 Ensembl Gene Id

GRIA3 Uniprot Gene Name

Gene Info:

Interpro Acc IPR001320

Uniprot Status Swiss-Prot

Interpro Short Name Iontro_glu_rcpt

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GRIA3 Display Id

GLUTAMATE RECEPTOR 3 PRECURSOR (GLUR-3) (GLUR-C) (GLUR-K3) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 3). [SOURCE:UNIPROT/SWISSPROT;ACC:P42263] Description

ENSG00000125675 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GRIA3 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass TC:1.A.10.1.4

Alternate Names:

PA28968 PharmGKB ID

Publications:

Chew et al., 1997, Growth factor-induced transcription of GluR1 increases functional AMPA receptor density in glial progenitor cells., J. Neurosci.

Dildy-Mayfield et al., 1996, Anesthetics produce subunit-selective actions on glutamate receptors., J. Pharmacol. Exp. Ther.

Alternate Names:

ENSG00000125675 Gene Symbol

GRIA3 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GLURC GENE_SYMBOL

GRIA3 GENE_SYMBOL

Glutamate receptor 3 UNIPROT