DGIdb - GRIA4 Gene Record

GRIA4 2893 Druggable Genome

Alternate Names:

2893
GLUTAMATE IONOTROPIC RECEPTOR AMPA TYPE SUBUNIT 4
GRIA4
GLUR4
GLUR4C
GLURD
GluA4
138246
4574
ENSG00000152578
OTTHUMG00000166236
P48058
GRIA4_HUMAN
GLUTAMATE RECEPTOR 4
GLUTAMATE RECEPTOR 4 PRECURSOR (GLUR-4) (GLUR4) (GLUR-D) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 4). [SOURCE:UNIPROT/SWISSPROT;ACC:P48058]
GluR-4
Glutamate receptor ionotropic, AMPA 4
GluR-D
AMPA-selective glutamate receptor 4
Glutamate receptor AMPA 4
T96235
NEDSGA
GluA4-ATD

Gene Info:

Target Class	Receptors
Target Subclass	TC:1.A.10.1
Interpro Short Name	Iontro_glu_rcpt
Interpro Type	Domain
Interpro Name	Ionotropic glutamate receptor
Interpro Acc	IPR001320
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Uniprot Evidence	2: Evidence at transcript level
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Denes et al., 2006, Talampanel a non-competitive AMPA-antagonist attenuates caspase-3 dependent apoptosis in mouse brain after transient focal cerebral ischemia., Brain Res. Bull.
Howes et al., 2007, Talampanel., Neurotherapeutics
Langan et al., 2003, Talampanel, a new antiepileptic drug: single- and multiple-dose pharmacokinetics and initial 1-week experience in patients with chronic intractable epilepsy., Epilepsia

TALAMPANEL GRIA4

Interaction Score: 4.42

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name talampanel

Novel drug target Established target

PMIDs:
16861112 17199027 12581229

Sources:
TdgClinicalTrial
PERAMPANEL GRIA4

Interaction Score: 3.31

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name E2007

Novel drug target Established target

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
MK-8777 GRIA4

Interaction Score: 1.1

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BECAMPANEL GRIA4

Interaction Score: 1.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SELURAMPANEL GRIA4

Interaction Score: 1.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

Trial Name BGG-492

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
ZONAMPANEL GRIA4

Interaction Score: 1.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MIBAMPATOR GRIA4

Interaction Score: 1.1

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions
PF-04958242 GRIA4

Interaction Score: 1.1

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CX1739 GRIA4

Interaction Score: 1.1

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions
FARAMPATOR GRIA4

Interaction Score: 1.1

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions
TEZAMPANEL GRIA4

Interaction Score: 0.98

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

Trial Name tezampanel, NGX424,NGX426

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
DASOLAMPANEL GRIA4

Interaction Score: 0.88

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs:
None found

Sources:
ChemblInteractions
IRAMPANEL GRIA4

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOPIRAMATE GRIA4

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000152578
- Version: 101_38
Alternate Names:

GRIA4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P48058
- Version: January-2014
Alternate Names:

GRIA4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass TC:1.A.10.1

Publications:
HopkinsGroom: P48058
- Version: 11-September-2012
Alternate Names:

GRIA4_HUMAN Uniprot Id

2893 Entrez Gene Id

P48058 Uniprot Accession

Gene Info:

Interpro Short Name Iontro_glu_rcpt

Interpro Type Domain

Interpro Name Ionotropic glutamate receptor

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000152578

Version: 26-July-2011

Alternate Names:

GLUTAMATE RECEPTOR 4 PRECURSOR (GLUR-4) (GLUR4) (GLUR-D) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 4). [SOURCE:UNIPROT/SWISSPROT;ACC:P48058] Description

GRIA4 Display Id

ENSG00000152578 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: GRIA4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

He et al., 1998, Effect of 6-OHDA injection on the AMPA glutamate receptor subunits in the substantia nigra of Sprague-Dawley rats., Neurosci. Lett.

Cheng et al., 1995, Basic fibroblast growth factor selectively increases AMPA-receptor subunit GluR1 protein level and differentially modulates Ca2+ responses to AMPA and NMDA in hippocampal neurons., J. Neurochem.

HingoraniCasas: ENSG00000152578
- Version: 31-May-2017
Alternate Names:

ENSG00000152578 Gene Symbol

GRIA4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: GLUR4
- Version: chembl_23
Alternate Names:

GLUR4 GENE_SYMBOL

GRIA4 GENE_SYMBOL

Glutamate receptor 4 UNIPROT

Gene Info:

Publications:
TTD: Glutamate receptor AMPA 4
- Version: 2020.06.01
Alternate Names:

GRIA4 TTD Gene Abbreviation

T96235 TTD Target ID

Gene Info:

Publications:
Pharos: GRIA4
- Version: 01-February-2022
Alternate Names:

Glutamate receptor 4 Gene Name

P48058 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Trial Name	E2007
Novel drug target	Established target
Direct Interaction	yes

Mechanism of Interaction	Glutamate receptor ionotropic AMPA positive allosteric modulator
Direct Interaction	yes

Mechanism of Interaction	Glutamate receptor ionotropic AMPA antagonist
Direct Interaction	yes

GRIA4_HUMAN	Uniprot Id
2893	Entrez Gene Id
P48058	Uniprot Accession

GLUTAMATE RECEPTOR 4 PRECURSOR (GLUR-4) (GLUR4) (GLUR-D) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 4). [SOURCE:UNIPROT/SWISSPROT;ACC:P48058]	Description
GRIA4	Display Id
ENSG00000152578	Ensembl Gene Id

GRIA4 Gene Record

GRIA4 2893 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name talampanel Novel drug target Established target

PMIDs: 16861112 17199027 12581229

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name E2007 Novel drug target Established target Direct Interaction yes

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes Trial Name BGG-492

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes Trial Name tezampanel, NGX424,NGX426

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000152578

Alternate Names: GRIA4 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P48058

Alternate Names: GRIA4 Gene Symbol

Gene Info: Target Class Receptors Target Subclass TC:1.A.10.1

Publications:

HopkinsGroom: P48058

Alternate Names: GRIA4_HUMAN Uniprot Id 2893 Entrez Gene Id P48058 Uniprot Accession

Gene Info: Interpro Short Name Iontro_glu_rcpt Interpro Type Domain Interpro Name Ionotropic glutamate receptor

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000152578

Alternate Names: GLUTAMATE RECEPTOR 4 PRECURSOR (GLUR-4) (GLUR4) (GLUR-D) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 4). [SOURCE:UNIPROT/SWISSPROT;ACC:P48058] Description GRIA4 Display Id ENSG00000152578 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name talampanel

Novel drug target Established target

PMIDs:
16861112 17199027 12581229

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name E2007

Novel drug target Established target

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

Trial Name BGG-492

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA positive allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

Trial Name tezampanel, NGX424,NGX426

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate receptor ionotropic AMPA antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

GRIA4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

GRIA4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass TC:1.A.10.1

Alternate Names:

GRIA4_HUMAN Uniprot Id

2893 Entrez Gene Id

P48058 Uniprot Accession

Gene Info:

Interpro Short Name Iontro_glu_rcpt

Interpro Type Domain

Interpro Name Ionotropic glutamate receptor

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GLUTAMATE RECEPTOR 4 PRECURSOR (GLUR-4) (GLUR4) (GLUR-D) (GLUTAMATE RECEPTOR IONOTROPIC, AMPA 4). [SOURCE:UNIPROT/SWISSPROT;ACC:P48058] Description

GRIA4 Display Id

ENSG00000152578 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000152578 Gene Symbol

GRIA4 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GLUR4 GENE_SYMBOL

GRIA4 GENE_SYMBOL

Glutamate receptor 4 UNIPROT

Alternate Names:

GRIA4 TTD Gene Abbreviation

T96235 TTD Target ID

Alternate Names:

Glutamate receptor 4 Gene Name

P48058 UniProt ID

Gene Categories:

ION CHANNEL