DGIdb - GRIN2A Gene Record

GRIN2A 2903 Druggable GenomeClinically Actionable

Alternate Names:

2903
GLUTAMATE IONOTROPIC RECEPTOR NMDA TYPE SUBUNIT 2A
GRIN2A
EPND
FESD
GluN2A
LKS
NMDAR2A
NR2A
138253
4585
ENSG00000183454
OTTHUMG00000129721
hNR2A
Glutamate receptor ionotropic, NMDA 2A
Glutamate [NMDA] receptor subunit epsilon-1
N-methyl D-aspartate receptor subtype 2A
Q12879
NMDE1_HUMAN
GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON 1 PRECURSOR (N-METHYL D- ASPARTATE RECEPTOR SUBTYPE 2A) (NR2A) (NMDAR2A) (HNR2A). [SOURCE:UNIPROT/SWISSPROT;ACC:Q12879]
PA28979
Glutamate receptor ionotropic NMDA 2A
T22285

Gene Info:

Target Subclass	Ligand_gated_ion_channels
Target Subclass	Glutamate
Transmembrane Helix Count	4
Target Main Class	Receptors
Target Subclass	Channels
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR001320
Interpro Short Name	Iontro_glu_rcpt
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Name	Ionotropic glutamate receptor
Interpro Type	Domain
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

CELL SURFACE
ION CHANNEL
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Rook Y et al., 2010, Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., J Med Chem
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Chen et al., 2005, Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels., J. Pharmacol. Exp. Ther.
Rogawski et al., 2003, The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease., CNS Drug Rev
Blanpied et al., 1997, Trapping channel block of NMDA-activated responses by amantadine and memantine., J. Neurophysiol.
Maler et al., 2005, Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons., Brain Res.
Bresink et al., 1996, Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells., Br. J. Pharmacol.
Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics
Milutinovic et al., 2007, Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters., Anesth. Analg.
Brosnan et al., 2007, Ammonia has anesthetic properties., Anesth. Analg.
Domingues et al., 2007, Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits., Neurochem. Int.
Liu et al., 2007, NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo., J. Neurosci.
Gabra et al., 2007, Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia., J. Pharmacol. Exp. Ther.
Frølund S et al., 2010, Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists., J Med Chem

MEMANTINE GRIN2A

Interaction Score: 3.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
20361801 15901795 14530799 9120573 16009352 8886398

Sources:
DTC TEND
GLYCINE GRIN2A

Interaction Score: 2.4

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

PMIDs:
17646495 17513636 17403555 17360906 17405869 11752352

Sources:
TTD
PHILANTHOTOXIN 343 GRIN2A

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20873775

Sources:
DTC
DIZOCILPINE GRIN2A

Interaction Score: 1.37

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

PMIDs:
20361801

Sources:
DTC
KETAMINE GRIN2A

Interaction Score: 1.03

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

PMIDs:
20361801

Sources:
DTC
DEXTROMETHORPHAN POLISTIREX GRIN2A

Interaction Score: 1.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor subunit epsilon 1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
DEXTROMETHORPHAN HYDROBROMIDE GRIN2A

Interaction Score: 0.69

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor subunit epsilon 1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FELBAMATE GRIN2A

Interaction Score: 0.52

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
11752352

Sources:
ChemblInteractions TEND
ESKETAMINE HYDROCHLORIDE GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESKETAMINE GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DELUCEMINE GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GW468816 GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LANICEMINE GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor blocker

PMIDs:
None found

Sources:
ChemblInteractions
CNS-5161 GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RAPASTINEL GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AZD8108 GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
KETAMINE HYDROCHLORIDE GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions
AV-101 GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
APIMOSTINEL GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEMANTINE HYDROCHLORIDE GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NEBOGLAMINE GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMANTADINE HYDROCHLORIDE GRIN2A

Interaction Score: 0.26

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INDANTADOL GRIN2A

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
NERAMEXANE MESYLATE GRIN2A

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
NBQX GRIN2A

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
RALFINAMIDE GRIN2A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE HYDROCHLORIDE GRIN2A

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE CITRATE GRIN2A

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ACAMPROSATE CALCIUM GRIN2A

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HALOPERIDOL GRIN2A

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27023437

Sources:
PharmGKB

Ensembl: ENSG00000183454
- Version: 101_38
Alternate Names:

GRIN2A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q12879
- Version: 11-September-2012
Alternate Names:

NMDE1_HUMAN Uniprot Id

ENSG00000183454 Ensembl Gene Id

GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-1 Uniprot Protein Name

Gene Info:

Interpro Acc IPR001320

Interpro Short Name Iontro_glu_rcpt

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: Q12879
- Version: 01-August-2011
Alternate Names:

ENSG00000183454 Ensembl Gene Id

GRIN2A Gene Symbol

2903 Entrez Gene Id

Gene Info:

Target Subclass Ligand_gated_ion_channels

Target Subclass Glutamate

Transmembrane Helix Count 4

Publications:

RussLampel: ENSG00000183454

Version: 26-July-2011

Alternate Names:

ENSG00000183454 Ensembl Gene Id

GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON 1 PRECURSOR (N-METHYL D- ASPARTATE RECEPTOR SUBTYPE 2A) (NR2A) (NMDAR2A) (HNR2A). [SOURCE:UNIPROT/SWISSPROT;ACC:Q12879] Description

GRIN2A Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: GRIN2A
- Version: 18-August-2020
Alternate Names:

PA28979 PharmGKB ID

Gene Info:

Publications:

Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics

DTC: GRIN2A

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Rook Y et al., 2010, Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents., J Med Chem

Frølund S et al., 2010, Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists., J Med Chem

ChemblInteractions: NMDAR2A
- Version: chembl_23
Alternate Names:

NMDAR2A GENE_SYMBOL

GRIN2A GENE_SYMBOL

Glutamate receptor ionotropic, NMDA 2A UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000183454
- Version: 31-May-2017
Alternate Names:

ENSG00000183454 Gene Symbol

GRIN2A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: GRIN2A
- Version: 01-February-2022
Alternate Names:

NMDAR2A GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
Tempus: GRIN2A
- Version: 11-November-2018
Alternate Names:

GRIN2A Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Glutamate receptor ionotropic NMDA 2A
- Version: 2020.06.01
Alternate Names:

NMDAR2A TTD Gene Abbreviation

T22285 TTD Target ID

Gene Info:

Publications:
Pharos: GRIN2A
- Version: 01-February-2022
Alternate Names:

Glutamate receptor ionotropic, NMDA 2A Gene Name

Q12879 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:
MskImpact: GRIN2A
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: GRIN2A
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: GRIN2A
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Direct Interaction	yes
Mechanism of Interaction	Glutamate [NMDA] receptor subunit epsilon 1 antagonist

Mechanism of Interaction	Glutamate [NMDA] receptor antagonist
Direct Interaction	yes

Mechanism of Interaction	Glutamate [NMDA] receptor negative allosteric modulator
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Glutamate [NMDA] receptor blocker

Mechanism of Interaction	Glutamate [NMDA] receptor partial agonist
Direct Interaction	yes

Mechanism of Interaction	Glutamate [NMDA] receptor positive allosteric modulator
Direct Interaction	yes

NMDE1_HUMAN	Uniprot Id
ENSG00000183454	Ensembl Gene Id
GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-1	Uniprot Protein Name

NMDAR2A	GENE_SYMBOL
GRIN2A	GENE_SYMBOL
Glutamate receptor ionotropic, NMDA 2A	UNIPROT

Glutamate receptor ionotropic, NMDA 2A	Gene Name
Q12879	UniProt ID

agonist (activating)
antagonist (inhibitory)

GRIN2A Gene Record

GRIN2A 2903 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 20361801 15901795 14530799 9120573 16009352 8886398

Sources: DTC TEND

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info:

PMIDs: 17646495 17513636 17403555 17360906 17405869 11752352

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20873775

Sources: DTC

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info:

PMIDs: 20361801

Sources: DTC

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info:

PMIDs: 20361801

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate [NMDA] receptor subunit epsilon 1 antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor subunit epsilon 1 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor antagonist Direct Interaction yes

PMIDs: 11752352

Sources: ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate [NMDA] receptor blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor partial agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor partial agonist Direct Interaction yes

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
20361801 15901795 14530799 9120573 16009352 8886398

Sources:
DTC TEND

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

PMIDs:
17646495 17513636 17403555 17360906 17405869 11752352

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
20873775

Sources:
DTC

Interaction Types & Directionality:

blocker (inhibitory)

PMIDs:
20361801

Sources:
DTC

Interaction Types & Directionality:

blocker (inhibitory)

PMIDs:
20361801

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor subunit epsilon 1 antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor subunit epsilon 1 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
11752352

Sources:
ChemblInteractions TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)