DGIdb - GRIN2B Gene Record

GRIN2B 2904 Druggable Genome

Alternate Names:

2904
GLUTAMATE IONOTROPIC RECEPTOR NMDA TYPE SUBUNIT 2B
GRIN2B
EIEE27
GluN2B
MRD6
NMDAR2B
NR2B
hNR3
138252
4586
ENSG00000273079
OTTHUMG00000137373
Q13224
NMDE2_HUMAN
ENSG00000150086
GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-2
GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON 2 PRECURSOR (N-METHYL D- ASPARTATE RECEPTOR SUBTYPE 2B) (NR2B) (NMDAR2B) (N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT 3) (NR3) (HNR3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13224]
NR3
N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT 3
N-METHYL D-ASPARTATE RECEPTOR SUBTYPE 2B
PA28980
Glutamate receptor ionotropic, NMDA 2B
Glutamate receptor ionotropic NMDA 2B
T76414
DEE27

Gene Info:

Target Main Class	Receptors
Target Subclass	Ligand_gated_ion_channels
Transmembrane Helix Count	4
Target Subclass	Glutamate
Target Subclass	Channels
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR001320
Interpro Name	Ionotropic glutamate receptor
Interpro Type	Domain
Interpro Short Name	Iontro_glu_rcpt
Human Readable Name	DRUGGABLE GENOME
Target Class	Receptors
Target Subclass	TC:1.A.10.1
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

CELL SURFACE
ION CHANNEL
DRUGGABLE GENOME

Publications:

López-Rodríguez R et al., 2013, Pharmacodynamic genetic variants related to antipsychotic adverse reactions in healthy volunteers., Pharmacogenomics
Sinor et al., 2000, NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro., J. Neurosci.
Hattori et al., 2006, Fyn is required for haloperidol-induced catalepsy in mice., J. Biol. Chem.
Steinmetz et al., 2002, A simple cell line based in vitro test system for N-methyl-D-aspartate (NMDA) receptor ligands., J. Neurosci. Methods
Zhuravliova et al., 2007, Haloperidol induces neurotoxicity by the NMDA receptor downstream signaling pathway, alternative from glutamate excitotoxicity., Neurochem. Int.
Gallagher et al., 1998, Modulation of the N-methyl-D-aspartate receptor by haloperidol: NR2B-specific interactions., J. Neurochem.
Gu et al., 2007, Effects of (-)-stepholidine on NMDA receptors: comparison with haloperidol and clozapine., Acta Pharmacol. Sin.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics
Kleckner et al., 1999, Subtype-selective antagonism of N-methyl-D-aspartate receptors by felbamate: insights into the mechanism of action., J. Pharmacol. Exp. Ther.
Chang et al., 2008, Molecular determinants of the anticonvulsant felbamate binding site in the N-methyl-D-aspartate receptor., J. Med. Chem.
Luszczki et al., 2008, Interactions of MRZ 2/576 with felbamate, lamotrigine, oxcarbazepine and topiramate in the mouse maximal electroshock-induced seizure model., Pharmacology
Harty et al., 2000, Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit., Epilepsy Res.
Molero P et al., 2018, Antidepressant Efficacy and Tolerability of Ketamine and Esketamine: A Critical Review., CNS Drugs
Karpyak VM et al., 2014, Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate., Transl Psychiatry
Rogawski et al., 2003, The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease., CNS Drug Rev
Nakazato et al., 2005, Brain but not spinal NR2B receptor is responsible for the anti-allodynic effect of an NR2B subunit-selective antagonist CP-101,606 in a rat chronic constriction injury model., Pharmacology
Maler et al., 2005, Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons., Brain Res.
Blanpied et al., 1997, Trapping channel block of NMDA-activated responses by amantadine and memantine., J. Neurophysiol.
Kashiwagi et al., 2002, Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore., Mol. Pharmacol.
Kim JI et al., 2017, Association of the GRIN2B rs2284411 polymorphism with methylphenidate response in attention-deficit/hyperactivity disorder., J Psychopharmacol
Taylor DL et al., 2016, Genetic association analysis of N-methyl-D-aspartate receptor subunit gene GRIN2B and clinical response to clozapine., Hum Psychopharmacol

MEMANTINE GRIN2B

Interaction Score: 2.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name memantine

Novel drug target Established target

Trial Name Namenda

PMIDs:
14530799 15452358 16009352 9120573 11854433

Sources:
TdgClinicalTrial TEND
RISLENEMDAZ GRIN2B

Interaction Score: 1.63

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
EVT-101 GRIN2B

Interaction Score: 1.63

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name EVT-101

Novel drug target Established target

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
RADIPRODIL GRIN2B

Interaction Score: 1.63

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
ACAMPROSATE GRIN2B

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25290263

Sources:
PharmGKB
FELBAMATE GRIN2B

Interaction Score: 1.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
10215667 18311896 18253065 10690753 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND
TRAXOPRODIL GRIN2B

Interaction Score: 0.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NERAMEXANE GRIN2B

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name neramexane mesylate

PMIDs:
None found

Sources:
TdgClinicalTrial
ESKETAMINE HYDROCHLORIDE GRIN2B

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AM-101

Novel drug target Established target

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
ESKETAMINE GRIN2B

Interaction Score: 0.46

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
29736744

Sources:
ChemblInteractions
LANICEMINE GRIN2B

Interaction Score: 0.46

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor blocker

Trial Name AZD-6765

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
CNS-5161 GRIN2B

Interaction Score: 0.46

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Trial Name CNS-5161

Novel drug target Established target

Mechanism of Interaction Glutamate [NMDA] receptor blocker

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
ELIPRODIL GRIN2B

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIMIRACETAM GRIN2B

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name dimiracetam, NT-11624

PMIDs:
None found

Sources:
TdgClinicalTrial
INDANTADOL GRIN2B

Interaction Score: 0.36

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Trial Name V3381

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
RAPASTINEL GRIN2B

Interaction Score: 0.23

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEMANTINE HYDROCHLORIDE GRIN2B

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NEBOGLAMINE GRIN2B

Interaction Score: 0.23

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LATREPIRDINE GRIN2B

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Dimebon

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
DELUCEMINE GRIN2B

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GW468816 GRIN2B

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AV-101 GRIN2B

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
APIMOSTINEL GRIN2B

Interaction Score: 0.23

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DEXANABINOL GRIN2B

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name dexanabinol, HU-211

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
AZD8108 GRIN2B

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
KETAMINE HYDROCHLORIDE GRIN2B

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
None found

Sources:
ChemblInteractions
HALOPERIDOL GRIN2B

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
11102491 16407246 11741727 17092607 9572299 17588330 11752352 27023437

Sources:
PharmGKB
AMANTADINE HYDROCHLORIDE GRIN2B

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NERAMEXANE MESYLATE GRIN2B

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NBQX GRIN2B

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
QUETIAPINE GRIN2B

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23859574

Sources:
PharmGKB
RALFINAMIDE GRIN2B

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE HYDROCHLORIDE GRIN2B

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE CITRATE GRIN2B

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METHYLPHENIDATE GRIN2B

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27624150

Sources:
PharmGKB
ACAMPROSATE CALCIUM GRIN2B

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RISPERIDONE GRIN2B

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23859574

Sources:
PharmGKB
CLOZAPINE GRIN2B

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26876050

Sources:
PharmGKB

Ensembl: ENSG00000273079
- Version: 101_38
Alternate Names:

GRIN2B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: Q13224
- Version: 01-August-2011
Alternate Names:

2904 Entrez Gene Id

Q13224 Uniprot Accession

GRIN2B Gene Symbol

Gene Info:

Target Main Class Receptors

Target Subclass Ligand_gated_ion_channels

Transmembrane Helix Count 4

Publications:
HopkinsGroom: Q13224
- Version: 11-September-2012
Alternate Names:

GRIN2B Uniprot Gene Name

NMDE2_HUMAN Uniprot Id

2904 Entrez Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR001320

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q13224
- Version: January-2014
Alternate Names:

GRIN2B Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass TC:1.A.10.1

Publications:

RussLampel: ENSG00000150086

Version: 26-July-2011

Alternate Names:

GRIN2B Display Id

ENSG00000150086 Ensembl Gene Id

GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON 2 PRECURSOR (N-METHYL D- ASPARTATE RECEPTOR SUBTYPE 2B) (NR2B) (NMDAR2B) (N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT 3) (NR3) (HNR3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13224] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: GRIN2B

Version: 18-August-2020

Alternate Names:

PA28980 PharmGKB ID

Gene Info:

Publications:

López-Rodríguez R et al., 2013, Pharmacodynamic genetic variants related to antipsychotic adverse reactions in healthy volunteers., Pharmacogenomics

Porcelli S et al., 2016, Possible biomarkers modulating haloperidol efficacy and/or tolerability., Pharmacogenomics

Kim JI et al., 2017, Association of the GRIN2B rs2284411 polymorphism with methylphenidate response in attention-deficit/hyperactivity disorder., J Psychopharmacol

ChemblInteractions: NMDAR2B
- Version: chembl_23
Alternate Names:

NMDAR2B GENE_SYMBOL

GRIN2B GENE_SYMBOL

Glutamate receptor ionotropic, NMDA 2B UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000150086
- Version: 31-May-2017
Alternate Names:

ENSG00000150086 Gene Symbol

GRIN2B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: GRIN2B
- Version: 01-February-2022
Alternate Names:

NMDAR2B GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
TTD: Glutamate receptor ionotropic NMDA 2B
- Version: 2020.06.01
Alternate Names:

NMDAR2B TTD Gene Abbreviation

T76414 TTD Target ID

Gene Info:

Publications:
Pharos: GRIN2B
- Version: 01-February-2022
Alternate Names:

Glutamate receptor ionotropic, NMDA 2B Gene Name

Q13224 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Trial Name	memantine
Novel drug target	Established target
Trial Name	Namenda

Mechanism of Interaction	Glutamate NMDA receptor; GRIN1/GRIN2B antagonist
Direct Interaction	yes

Trial Name	EVT-101
Novel drug target	Established target
Mechanism of Interaction	Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Mechanism of Interaction	Glutamate [NMDA] receptor antagonist
Direct Interaction	yes
Trial Name	-

Trial Name	AM-101
Novel drug target	Established target
Mechanism of Interaction	Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction	yes
Mechanism of Interaction	Glutamate [NMDA] receptor blocker
Trial Name	AZD-6765

Trial Name	CNS-5161
Novel drug target	Established target
Mechanism of Interaction	Glutamate [NMDA] receptor blocker

Mechanism of Interaction	Glutamate [NMDA] receptor partial agonist
Direct Interaction	yes

Mechanism of Interaction	Glutamate [NMDA] receptor positive allosteric modulator
Direct Interaction	yes

Trial Name	dexanabinol, HU-211
Novel drug target	Established target

GRIN2B	Uniprot Gene Name
NMDE2_HUMAN	Uniprot Id
2904	Entrez Gene Id

GRIN2B	Display Id
ENSG00000150086	Ensembl Gene Id
GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON 2 PRECURSOR (N-METHYL D- ASPARTATE RECEPTOR SUBTYPE 2B) (NR2B) (NMDAR2B) (N-METHYL-D-ASPARTATE RECEPTOR SUBUNIT 3) (NR3) (HNR3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13224]	Description

NMDAR2B	GENE_SYMBOL
GRIN2B	GENE_SYMBOL
Glutamate receptor ionotropic, NMDA 2B	UNIPROT

Glutamate receptor ionotropic, NMDA 2B	Gene Name
Q13224	UniProt ID

GRIN2B Gene Record

GRIN2B 2904 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name memantine Novel drug target Established target Trial Name Namenda

PMIDs: 14530799 15452358 16009352 9120573 11854433

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name EVT-101 Novel drug target Established target Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25290263

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor antagonist Direct Interaction yes Trial Name -

PMIDs: 10215667 18311896 18253065 10690753 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name neramexane mesylate

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name AM-101 Novel drug target Established target Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs: 29736744

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate [NMDA] receptor blocker Trial Name AZD-6765

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Trial Name CNS-5161 Novel drug target Established target Mechanism of Interaction Glutamate [NMDA] receptor blocker

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name dimiracetam, NT-11624

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate [NMDA] receptor antagonist Trial Name V3381

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor partial agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Dimebon Novel drug target Established target

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name memantine

Novel drug target Established target

Trial Name Namenda

PMIDs:
14530799 15452358 16009352 9120573 11854433

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name EVT-101

Novel drug target Established target

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
25290263

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
10215667 18311896 18253065 10690753 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate NMDA receptor; GRIN1/GRIN2B antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name neramexane mesylate

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AM-101

Novel drug target Established target

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
29736744

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor blocker

Trial Name AZD-6765

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Trial Name CNS-5161

Novel drug target Established target

Mechanism of Interaction Glutamate [NMDA] receptor blocker

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name dimiracetam, NT-11624

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Trial Name V3381

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Dimebon

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes