DGIdb - GRIN3A Gene Record

GRIN3A 116443 Druggable Genome

Alternate Names:

116443
GLUTAMATE IONOTROPIC RECEPTOR NMDA TYPE SUBUNIT 3A
GRIN3A
GluN3A
NMDAR-L
NR3A
606650
16767
ENSG00000198785
OTTHUMG00000020387
Q8TCU5
KIAA1973
N-methyl-D-aspartate receptor subtype 3A
NMDAR3A
Glutamate receptor ionotropic, NMDA 3A
NMD3A_HUMAN
GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3A PRECURSOR (N-METHYL-D-ASPARTATE RECEPTOR SUBTYPE NR3A) (NMDAR-L). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8TCU5]
GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3A
PA28983

Gene Info:

Transmembrane Helix Count	4
Target Subclass	Channels
Target Main Class	Receptors
Target Subclass	Glutamate
Target Subclass	Ligand_gated_ion_channels
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR001320
Interpro Short Name	Iontro_glu_rcpt
Interpro Name	Ionotropic glutamate receptor
Interpro Type	Domain
Target Class	Receptors
Target Subclass	TC:1.A.10.1
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Kornhuber et al., 1995, Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies., J. Neural Transm. Gen. Sect.
Smothers et al., 2007, Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits., J. Pharmacol. Exp. Ther.
Rogawski et al., 2003, The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease., CNS Drug Rev
Schrattenholz et al., 2006, NMDA receptors are not alone: dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate-signalling., Curr Top Med Chem
Chatterton et al., 2002, Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits., Nature
Foster et al., 2006, Glutamate- and GABA-based CNS therapeutics., Curr Opin Pharmacol
Wong et al., 1988, Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices., Neurosci. Lett.
Chou et al., 1999, Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan., Brain Res.
Kamel et al., 2008, N-methyl-D-aspartate (NMDA) antagonists--S(+)-ketamine, dextrorphan, and dextromethorphan--act as calcium antagonists on bovine cerebral arteries., J Neurosurg Anesthesiol
Radovanović et al., [Ketamine: the past 30 years and its future]., Med. Pregl.
Sinner et al., 2008, Ketamine., Handb Exp Pharmacol
Harrison et al., 1985, Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex., Br. J. Pharmacol.
Ma JZ et al., 2010, Significant association of glutamate receptor, ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers., Hum Genet

KETAMINE GRIN3A

Interaction Score: 3.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name amitriptyline + ketamine,Epicept NP-1

Novel drug target Established target

Trial Name nasal ketamine,Ereska

PMIDs:
17502428 14740534 18175098 2858237

Sources:
TdgClinicalTrial TEND
MEMANTINE GRIN3A

Interaction Score: 2.89

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Namenda

Novel drug target Established target

Trial Name memantine

PMIDs:
17502428 14530799 16719808 11823786 16377242

Sources:
TdgClinicalTrial TEND
DEXTROMETHORPHAN GRIN3A

Interaction Score: 2.4

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name AVP-923

Novel drug target Established target

Trial Name morphine/dextromethorphan,MorphiDex

PMIDs:
2897648 17016423 17139284 10064839 18812887

Sources:
TdgClinicalTrial TEND
ORPHENADRINE GRIN3A

Interaction Score: 2.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 8788072

Sources:
TdgClinicalTrial TEND
FELBAMATE GRIN3A

Interaction Score: 0.86

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
ACAMPROSATE GRIN3A

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name acamprosate,Campral

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
NERAMEXANE GRIN3A

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name neramexane mesylate

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ESKETAMINE HYDROCHLORIDE GRIN3A

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

Trial Name AM-101

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
LANICEMINE GRIN3A

Interaction Score: 0.59

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name AZD-6765

Mechanism of Interaction Glutamate [NMDA] receptor blocker

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
CNS-5161 GRIN3A

Interaction Score: 0.59

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name CNS-5161

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
INDANTADOL GRIN3A

Interaction Score: 0.46

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name V3381

Novel drug target Established target

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
RAPASTINEL GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GW468816 GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NEBOGLAMINE GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
APIMOSTINEL GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
KETAMINE HYDROCHLORIDE GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MEMANTINE HYDROCHLORIDE GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AV-101 GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DELUCEMINE GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
DEXANABINOL GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name dexanabinol, HU-211

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
AZD8108 GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESKETAMINE GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LATREPIRDINE GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Dimebon

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
AMANTADINE HYDROCHLORIDE GRIN3A

Interaction Score: 0.26

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NERAMEXANE MESYLATE GRIN3A

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RALFINAMIDE GRIN3A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE HYDROCHLORIDE GRIN3A

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
ORPHENADRINE CITRATE GRIN3A

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
NICOTINE GRIN3A

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20084518

Sources:
PharmGKB
ACAMPROSATE CALCIUM GRIN3A

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000198785
- Version: 101_38
Alternate Names:

GRIN3A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: Q8TCU5
- Version: 01-August-2011
Alternate Names:

GRIN3A Gene Symbol

Q8TCU5 Uniprot Accession

116443 Entrez Gene Id

Gene Info:

Transmembrane Helix Count 4

Target Subclass Channels

Target Main Class Receptors

Publications:

RussLampel: ENSG00000198785

Version: 26-July-2011

Alternate Names:

GRIN3A Display Id

GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3A PRECURSOR (N-METHYL-D-ASPARTATE RECEPTOR SUBTYPE NR3A) (NMDAR-L). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8TCU5] Description

ENSG00000198785 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q8TCU5
- Version: January-2014
Alternate Names:

GRIN3A Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass TC:1.A.10.1

Publications:
HopkinsGroom: Q8TCU5
- Version: 11-September-2012
Alternate Names:

GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3A Uniprot Protein Name

NMD3A_HUMAN Uniprot Id

ENSG00000198785 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR001320

Gene Categories:

DRUGGABLE GENOME

Publications:
PharmGKB: GRIN3A
- Version: 18-August-2020
Alternate Names:

PA28983 PharmGKB ID

Gene Info:

Publications:

Ma JZ et al., 2010, Significant association of glutamate receptor, ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- and African-American smokers., Hum Genet
HingoraniCasas: ENSG00000198785
- Version: 31-May-2017
Alternate Names:

ENSG00000198785 Gene Symbol

GRIN3A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: KIAA1973
- Version: chembl_23
Alternate Names:

KIAA1973 GENE_SYMBOL

GRIN3A GENE_SYMBOL

Glutamate receptor ionotropic, NMDA 3A UNIPROT

Gene Info:

Publications:
Pharos: GRIN3A
- Version: 01-February-2022
Alternate Names:

Glutamate receptor ionotropic, NMDA 3A Gene Name

Q8TCU5 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Trial Name	amitriptyline + ketamine,Epicept NP-1
Novel drug target	Established target
Trial Name	nasal ketamine,Ereska

Trial Name	Namenda
Novel drug target	Established target
Trial Name	memantine

Trial Name	AVP-923
Novel drug target	Established target
Trial Name	morphine/dextromethorphan,MorphiDex

Trial Name	acamprosate,Campral
Novel drug target	Established target

Trial Name	neramexane mesylate
Novel drug target	Established target

Mechanism of Interaction	Glutamate [NMDA] receptor negative allosteric modulator
Direct Interaction	yes
Trial Name	AM-101

Trial Name	V3381
Novel drug target	Established target
Direct Interaction	yes

Mechanism of Interaction	Glutamate [NMDA] receptor partial agonist
Direct Interaction	yes

Mechanism of Interaction	Glutamate [NMDA] receptor antagonist
Direct Interaction	yes

Mechanism of Interaction	Glutamate [NMDA] receptor positive allosteric modulator
Direct Interaction	yes

Trial Name	dexanabinol, HU-211
Novel drug target	Established target

GRIN3A	Gene Symbol
Q8TCU5	Uniprot Accession
116443	Entrez Gene Id

GRIN3A	Display Id
GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3A PRECURSOR (N-METHYL-D-ASPARTATE RECEPTOR SUBTYPE NR3A) (NMDAR-L). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8TCU5]	Description
ENSG00000198785	Ensembl Gene Id

GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3A	Uniprot Protein Name
NMD3A_HUMAN	Uniprot Id
ENSG00000198785	Ensembl Gene Id

KIAA1973	GENE_SYMBOL
GRIN3A	GENE_SYMBOL
Glutamate receptor ionotropic, NMDA 3A	UNIPROT

Glutamate receptor ionotropic, NMDA 3A	Gene Name
Q8TCU5	UniProt ID

GRIN3A Gene Record

GRIN3A 116443 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name amitriptyline + ketamine,Epicept NP-1 Novel drug target Established target Trial Name nasal ketamine,Ereska

PMIDs: 17502428 14740534 18175098 2858237

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Namenda Novel drug target Established target Trial Name memantine

PMIDs: 17502428 14530799 16719808 11823786 16377242

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name AVP-923 Novel drug target Established target Trial Name morphine/dextromethorphan,MorphiDex

PMIDs: 2897648 17016423 17139284 10064839 18812887

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284 8788072

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name acamprosate,Campral Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name neramexane mesylate Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes Trial Name AM-101

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Novel drug target Established target Trial Name AZD-6765 Mechanism of Interaction Glutamate [NMDA] receptor blocker

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Novel drug target Established target Trial Name CNS-5161 Direct Interaction yes

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name V3381 Novel drug target Established target Direct Interaction yes

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor partial agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor partial agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name amitriptyline + ketamine,Epicept NP-1

Novel drug target Established target

Trial Name nasal ketamine,Ereska

PMIDs:
17502428 14740534 18175098 2858237

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Namenda

Novel drug target Established target

Trial Name memantine

PMIDs:
17502428 14530799 16719808 11823786 16377242

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name AVP-923

Novel drug target Established target

Trial Name morphine/dextromethorphan,MorphiDex

PMIDs:
2897648 17016423 17139284 10064839 18812887

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 8788072

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name acamprosate,Campral

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name neramexane mesylate

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

Trial Name AM-101

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name AZD-6765

Mechanism of Interaction Glutamate [NMDA] receptor blocker

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name CNS-5161

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name V3381

Novel drug target Established target

Direct Interaction yes

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name dexanabinol, HU-211

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial