116444 |
GLUTAMATE IONOTROPIC RECEPTOR NMDA TYPE SUBUNIT 3B |
GRIN3B |
GluN3B |
NR3B |
606651 |
16768 |
ENSG00000116032 |
OTTHUMG00000181904 |
O60391 |
NMD3B_HUMAN |
GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3B |
N-methyl-D-aspartate receptor subtype 3B |
NMDAR3B |
Glutamate receptor ionotropic, NMDA 3B |
GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3B PRECURSOR (N-METHYL-D-ASPARTATE RECEPTOR SUBTYPE NR3B) (NR3B) (NMDAR3B) (FRAGMENT). [SOURCE:UNIPROT/SWISSPROT;ACC:O60391] |
Interpro Short Name | Iontro_glu_rcpt |
Interpro Acc | IPR001320 |
Interpro Name | Ionotropic glutamate receptor |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 2: Evidence at transcript level |
Interpro Type | Domain |
Uniprot Status | Swiss-Prot |
Target Class | Receptors |
Target Subclass | TC:1.A.10.1 |
Transmembrane Helix Count | 5 |
Target Subclass | Glutamate |
Target Main Class | Receptors |
Target Subclass | Ligand_gated_ion_channels |
Target Subclass | Channels |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
blocker (inhibitory) |
Trial Name | AZD-6765 |
Novel drug target | Established target |
Mechanism of Interaction | Glutamate [NMDA] receptor blocker |
blocker (inhibitory) |
Trial Name | CNS-5161 |
Novel drug target | Established target |
Mechanism of Interaction | Glutamate [NMDA] receptor blocker |
n/a |
Trial Name | AM-101 |
Novel drug target | Established target |
Mechanism of Interaction | Glutamate [NMDA] receptor negative allosteric modulator |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
Trial Name | V3381 |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | Glutamate [NMDA] receptor negative allosteric modulator |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | Glutamate [NMDA] receptor negative allosteric modulator |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
n/a |
Mechanism of Interaction | Glutamate [NMDA] receptor negative allosteric modulator |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
n/a |
Trial Name | Dimebon |
Novel drug target | Established target |
n/a |
Trial Name | dexanabinol, HU-211 |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
partial agonist (activating) |
Mechanism of Interaction | Glutamate [NMDA] receptor partial agonist |
Direct Interaction | yes |
partial agonist (activating) |
Mechanism of Interaction | Glutamate [NMDA] receptor partial agonist |
Direct Interaction | yes |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate [NMDA] receptor positive allosteric modulator |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
GRIN3B | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
116444 | Entrez Gene Id |
O60391 | Uniprot Accession |
GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3B | Uniprot Protein Name |
Interpro Short Name | Iontro_glu_rcpt |
Interpro Acc | IPR001320 |
Interpro Name | Ionotropic glutamate receptor |
DRUGGABLE GENOME |
GRIN3B | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.10.1 |
GRIN3B | Display Id |
ENSG00000116032 | Ensembl Gene Id |
GLUTAMATE [NMDA] RECEPTOR SUBUNIT 3B PRECURSOR (N-METHYL-D-ASPARTATE RECEPTOR SUBTYPE NR3B) (NR3B) (NMDAR3B) (FRAGMENT). [SOURCE:UNIPROT/SWISSPROT;ACC:O60391] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
ENSG00000116032 | Ensembl Gene Id |
116444 | Entrez Gene Id |
GRIN3B | Gene Symbol |
Transmembrane Helix Count | 5 |
Target Subclass | Glutamate |
Target Main Class | Receptors |
ENSG00000116032 | Gene Symbol |
GRIN3B | Ensembl Id |
DRUGGABLE GENOME |
GRIN3B | GENE_SYMBOL |
Glutamate receptor ionotropic, NMDA 3B | UNIPROT |
N-methyl-D-aspartate receptor subtype 3B | UNIPROT |
Glutamate receptor ionotropic, NMDA 3B | Gene Name |
O60391 | UniProt ID |
ION CHANNEL |