DGIdb - GRM2 Gene Record

GRM2 2912 Druggable Genome

Alternate Names:

2912
GLUTAMATE METABOTROPIC RECEPTOR 2
GRM2
GLUR2
GPRC1B
MGLUR2
mGlu2
604099
4594
ENSG00000164082
OTTHUMG00000156902
METABOTROPIC GLUTAMATE RECEPTOR 2 PRECURSOR (MGLUR2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q14416]
Q14416
GRM2_HUMAN
METABOTROPIC GLUTAMATE RECEPTOR 2
T62820

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Uniprot Evidence	2: Evidence at transcript level
Interpro Type	Family
Interpro Name	GPCR, family 3
Interpro Short Name	GPCR_3
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Acc	IPR000337
Uniprot Status	Swiss-Prot
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Glutamate
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Lapidus KA et al., 2013, Novel glutamatergic drugs for the treatment of mood disorders., Neuropsychiatr Dis Treat

JNJ-40411813 GRM2

Interaction Score: 17.67

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Trial Name ADX-71149

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
LY2979165 GRM2

Interaction Score: 17.67

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
DECOGLURANT GRM2

Interaction Score: 13.25

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 2 modulator

Direct Interaction yes

PMIDs:
23976856

Sources:
ChemblInteractions TTD
LY-2300559 GRM2

Interaction Score: 4.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
POMAGLUMETAD METHIONIL GRM2

Interaction Score: 4.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LY404039 GRM2

Interaction Score: 4.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LY2969822 GRM2

Interaction Score: 4.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000164082
- Version: 101_38
Alternate Names:

GRM2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: Q14416
- Version: 11-September-2012
Alternate Names:

ENSG00000164082 Ensembl Gene Id

Q14416 Uniprot Accession

GRM2 Uniprot Gene Name

Gene Info:

Uniprot Evidence 2: Evidence at transcript level

Interpro Type Family

Interpro Name GPCR, family 3

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000164082
- Version: 26-July-2011
Alternate Names:

METABOTROPIC GLUTAMATE RECEPTOR 2 PRECURSOR (MGLUR2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q14416] Description

GRM2 Display Id

ENSG00000164082 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q14416
- Version: January-2014
Alternate Names:

GRM2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Glutamate

Publications:
TTD: Metabotropic glutamate receptor 2
- Version: 2020.06.01
Alternate Names:

mGluR2 TTD Gene Abbreviation

T62820 TTD Target ID

Gene Info:

Publications:

Lapidus KA et al., 2013, Novel glutamatergic drugs for the treatment of mood disorders., Neuropsychiatr Dis Treat
NCI: GRM2
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Robbe et al., 2002, Metabotropic glutamate receptor 2/3-dependent long-term depression in the nucleus accumbens is blocked in morphine withdrawn mice., Eur. J. Neurosci.
HingoraniCasas: ENSG00000164082
- Version: 31-May-2017
Alternate Names:

ENSG00000164082 Gene Symbol

GRM2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: GPRC1B
- Version: chembl_23
Alternate Names:

MGLUR2 GENE_SYMBOL

GRM2 GENE_SYMBOL

Metabotropic glutamate receptor 2 UNIPROT

Gene Info:

Publications:
GO: GRM2
- Version: 01-February-2022
Alternate Names:

GPRC1B GO Gene Synonym

MGLUR2 GO Gene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
dGene: GRM2
- Version: 27-Jun-2013
Alternate Names:

2912 Gene ID

GLUR2 dGene Synonym

GPRC1B dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Mechanism of Interaction	Metabotropic glutamate receptor 2 agonist
Direct Interaction	yes

Mechanism of Interaction	Metabotropic glutamate receptor 2 modulator
Direct Interaction	yes

ENSG00000164082	Ensembl Gene Id
Q14416	Uniprot Accession
GRM2	Uniprot Gene Name

METABOTROPIC GLUTAMATE RECEPTOR 2 PRECURSOR (MGLUR2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q14416]	Description
GRM2	Display Id
ENSG00000164082	Ensembl Gene Id

MGLUR2	GENE_SYMBOL
GRM2	GENE_SYMBOL
Metabotropic glutamate receptor 2	UNIPROT

Trial Name	ADX-71149
Novel drug target	Novel Target

mGluR2	TTD Gene Abbreviation
T62820	TTD Target ID

GRM2 Gene Record

GRM2 2912 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

JNJ-40411813 GRM2

Interaction Types & Directionality: allosteric modulator

Interaction Info: Trial Name ADX-71149 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial TTD

LY2979165 GRM2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Metabotropic glutamate receptor 2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

DECOGLURANT GRM2

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Metabotropic glutamate receptor 2 modulator Direct Interaction yes

PMIDs: 23976856

Sources: ChemblInteractions TTD

LY-2300559 GRM2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

POMAGLUMETAD METHIONIL GRM2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Metabotropic glutamate receptor 2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

LY404039 GRM2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Metabotropic glutamate receptor 2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

LY2969822 GRM2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Metabotropic glutamate receptor 2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000164082

Alternate Names: GRM2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: Q14416

Alternate Names: ENSG00000164082 Ensembl Gene Id Q14416 Uniprot Accession GRM2 Uniprot Gene Name

Gene Info: Uniprot Evidence 2: Evidence at transcript level Interpro Type Family Interpro Name GPCR, family 3

Gene Categories: G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000164082

Alternate Names: METABOTROPIC GLUTAMATE RECEPTOR 2 PRECURSOR (MGLUR2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q14416] Description GRM2 Display Id ENSG00000164082 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: Q14416

Alternate Names: GRM2 Gene Symbol

Gene Info: Target Class Receptors Target Subclass GPCR Target Subclass Glutamate

Publications:

TTD: Metabotropic glutamate receptor 2

Alternate Names: mGluR2 TTD Gene Abbreviation T62820 TTD Target ID

Gene Info:

Publications: Lapidus KA et al., 2013, Novel glutamatergic drugs for the treatment of mood disorders., Neuropsychiatr Dis Treat

NCI: GRM2

Alternate Names:

Gene Info:

Publications: Robbe et al., 2002, Metabotropic glutamate receptor 2/3-dependent long-term depression in the nucleus accumbens is blocked in morphine withdrawn mice., Eur. J. Neurosci.

HingoraniCasas: ENSG00000164082

Alternate Names: ENSG00000164082 Gene Symbol GRM2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: GPRC1B

Alternate Names: MGLUR2 GENE_SYMBOL GRM2 GENE_SYMBOL Metabotropic glutamate receptor 2 UNIPROT

Gene Info:

Publications:

GO: GRM2

Alternate Names: GPRC1B GO Gene Synonym MGLUR2 GO Gene Synonym

Gene Info:

Gene Categories: G PROTEIN COUPLED RECEPTOR

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Trial Name ADX-71149

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 2 modulator

Direct Interaction yes

PMIDs:
23976856

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Metabotropic glutamate receptor 2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

GRM2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000164082 Ensembl Gene Id

Q14416 Uniprot Accession

GRM2 Uniprot Gene Name

Gene Info:

Uniprot Evidence 2: Evidence at transcript level

Interpro Type Family

Interpro Name GPCR, family 3

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Alternate Names:

METABOTROPIC GLUTAMATE RECEPTOR 2 PRECURSOR (MGLUR2). [SOURCE:UNIPROT/SWISSPROT;ACC:Q14416] Description

GRM2 Display Id

ENSG00000164082 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

GRM2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Glutamate

Alternate Names:

mGluR2 TTD Gene Abbreviation

T62820 TTD Target ID

Publications:

Lapidus KA et al., 2013, Novel glutamatergic drugs for the treatment of mood disorders., Neuropsychiatr Dis Treat

Publications:

Robbe et al., 2002, Metabotropic glutamate receptor 2/3-dependent long-term depression in the nucleus accumbens is blocked in morphine withdrawn mice., Eur. J. Neurosci.

Alternate Names:

ENSG00000164082 Gene Symbol

GRM2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

MGLUR2 GENE_SYMBOL

GRM2 GENE_SYMBOL

Metabotropic glutamate receptor 2 UNIPROT

Alternate Names:

GPRC1B GO Gene Synonym

MGLUR2 GO Gene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Alternate Names:

2912 Gene ID

GLUR2 dGene Synonym

GPRC1B dGene Synonym

Gene Categories:

G PROTEIN COUPLED RECEPTOR