GUCY1A1 Gene Record

  • GUCY1A1 2982 Druggable Genome

    Alternate Names:

    2982
    GUANYLATE CYCLASE 1 SOLUBLE SUBUNIT ALPHA
    GUCY1A3
    GC-SA3
    GUC1A3
    GUCA3
    GUCSA3
    GUCY1A1
    MYMY6
    139396
    4685
    ENSG00000164116
    OTTHUMG00000161700
    Q02108
    GCS-alpha-3
    Soluble guanylate cyclase large subunit
    GCS-alpha-1
    Guanylate cyclase soluble subunit alpha-3
    GUANYLATE CYCLASE SOLUBLE, ALPHA-3 CHAIN (EC 4.6.1.2) (GCS-ALPHA-3) (SOLUBLE GUANYLATE CYCLASE LARGE SUBUNIT) (GCS-ALPHA-1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02108]
    GCYA3_HUMAN
    Guanylate cyclase 1 soluble subunit alpha 1
    GC-S-alpha-1
    Guanylate cyclase soluble subunit alpha-1

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:4.6.1.2
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Adenylyl cyclase class-3/4/guanylyl cyclase
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001054
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Interpro Short Name A/G_cyclase
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

  • RIOCIGUAT   GUCY1A1

    Interaction Score: 4.12

    Interaction Types & Directionality:
    activator (activating)
    positive modulator (activating)

    Interaction Info:
    Trial Name riociguat, BAY-63-2521
    Novel drug target Novel Target
    Mechanism of Interaction Soluble guanylate cyclase positive allosteric modulator

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ISOSORBIDE DINITRATE   GUCY1A1

    Interaction Score: 2.58

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NITRIC OXIDE   GUCY1A1

    Interaction Score: 2.58

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SODIUM NITROPRUSSIDE   GUCY1A1

    Interaction Score: 2.58

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Soluble guanylate cyclase activator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISOSORBIDE MONONITRATE   GUCY1A1

    Interaction Score: 2.06

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NITROGLYCERIN   GUCY1A1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Soluble guanylate cyclase activator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000164116

    • Version: 101_38

    Alternate Names:
    GUCY1A1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q02108

    • Version: January-2014

    Alternate Names:
    GUCY1A3 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:4.6.1.2

    Publications:

  • RussLampel: ENSG00000164116

    • Version: 26-July-2011

    Alternate Names:
    GUCY1A3 Display Id
    GUANYLATE CYCLASE SOLUBLE, ALPHA-3 CHAIN (EC 4.6.1.2) (GCS-ALPHA-3) (SOLUBLE GUANYLATE CYCLASE LARGE SUBUNIT) (GCS-ALPHA-1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02108] Description
    ENSG00000164116 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q02108

    • Version: 11-September-2012

    Alternate Names:
    GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-3 Uniprot Protein Name
    2982 Entrez Gene Id
    ENSG00000164116 Ensembl Gene Id

    Gene Info:
    Interpro Name Adenylyl cyclase class-3/4/guanylyl cyclase
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001054

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HingoraniCasas: ENSG00000164116

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000164116 Gene Symbol
    GUCY1A3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: GUC1A3

    • Version: chembl_23

    Alternate Names:
    GUCSA3 GENE_SYMBOL
    GUCY1A1 GENE_SYMBOL
    GUCY1A3 GENE_SYMBOL

    Gene Info:

    Publications:

  • HumanProteinAtlas: GUCY1A1

    • Version: 19.3

    Alternate Names:
    ENSG00000164116 Ensembl Gene ID
    GC-SA3 Human Protein Atlas Gene Synonym
    GUC1A3 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: GUCY1A1

    • Version: 01-February-2022

    Alternate Names:
    Guanylate cyclase soluble subunit alpha-1 Gene Name
    Q02108 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications: